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HAMAP rule MF_01837

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General rule information [?]

Accession MF_01837
Dates 13-SEP-2004 (Created)
17-FEB-2023 (Last updated, Version 18)
Name Kinase_SasA
Scope(s) Bacteria
Template(s) Q06904 (SASA_SYNE7); [ Recover all ]
Triggered by HAMAP; MF_01837 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier SASA
Protein name RecName: Full=Adaptive-response sensory-kinase SasA;
AltName: Full=Sensor histidine kinase SasA;
Gene name Name=sasA;

Comments [?]

FUNCTIONMember of the two-component regulatory system SasA/RpaA involved in genome-wide circadian gene expression. One of several clock output pathways. Participates in the Kai clock protein complex, the main circadian regulator in cyanobacteria, via its interaction with KaiC. KaiC enhances the autophosphorylation activity of SasA, which then transfers its phosphate group to RpaA to activate it. In addition to its output function, recruits fold-shifted KaiB (KaiB(fs)) to KaiC to cooperatively form the KaiB(6):KaiC(6) complex (independent of SasA kinase activity). Required for robustness of the circadian rhythm of gene expression and is involved in clock output, also required for adaptation to light/dark cycles.
CATALYTIC ACTIVITY Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L- histidine.; EC=;
case not <OC:Prochlorococcus>
SUBUNITHomooligomerizes. Interacts with KaiC. Participates in the KaiABC clock complex, whose core is composed of a KaiC homohexamer, 6 KaiB and up to 6 KaiA dimers. SasA and KaiB(fs) compete to bind to KaiC.
end case
case <OC:Prochlorococcus>
SUBUNITHomooligomerizes. Interacts with KaiC. Participates in the KaiBC complex, whose core is composed of a KaiC homohexamer and 6 KaiB.
end case
DOMAINThe N-terminus interacts with KaiC, while the C-terminal histidine kinase domain autophosphorylates and is probably responsible for self-oligomerization. The N-terminal domain stimulates the C- terminus to autophosphorylate.

Keywords [?]

Gene Ontology [?]

GO:0007623; Biological process:circadian rhythm
GO:0004673; Molecular function:protein histidine kinase activity

Cross-references [?]

Pfam PF02518; HATPase_c; 1;
Pfam PF00512; HisKA; 1;
Pfam PF07689; KaiB; 1;

Features [?]

From: SASA_SYNE7 (Q06904)
Key From To Description Tag Condition FTGroup
MOD_RES 161 161 /note="Phosphohistidine; by autocatalysis" H

Additional information [?]

Size range 370-401 amino acids
Related rules None
Fusion Nter: None Cter: None

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