HAMAP rule MF_01838
General rule information
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| Accession | MF_01838 |
| Dates | 11-MAR-2005 (Created) 17-FEB-2023 (Last updated, Version 27) |
| Name | FabV_reductase |
| Scope | Bacteria |
| Templates | Q62L02 (FABV_BURMA); Q9KRA3 (FABV1_VIBCH); Q97LU2 (FABV_CLOAB); Q73Q47 (FABV_TREDE); Q2P9J6 (FABV_XANOM); Q8Z9U1 (FABV_YERPE); Q9HZP8 (FABV_PSEAE): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
|
case <OC:Bacillota> or <OC:Spirochaetota>
| Protein name |
|
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else
| Protein name |
|
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end case
| Gene name |
|
Comments
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case <OC:Bacillota> or <OC:Spirochaetota>
| Function | Involved in the fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to a coenzyme A (CoA). |
| Catalytic activity | RHEA:18177: a 2,3-saturated acyl-CoA + NAD(+) = a (2E)-enoyl-CoA + H(+) + NADH
EC 1.3.1.44 |
else
| Function | Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). |
| Catalytic activity | RHEA:10240: a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + H(+) + NADH
EC 1.3.1.9 |
end case
| Pathway | Lipid metabolism; fatty acid biosynthesis. |
| Subunit | Monomer. |
| Similarity | Belongs to the TER reductase family. |
Keywords
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Fatty acid biosynthesis
Fatty acid metabolism
Lipid metabolism
Lipid biosynthesis
NAD
Oxidoreductase
Fatty acid metabolism
Lipid metabolism
Lipid biosynthesis
NAD
Oxidoreductase
Gene Ontology
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case <OC:Bacillota> or <OC:Spirochaetota>
GO:0050343; Molecular function: trans-2-enoyl-CoA reductase (NAD+) activity.
else
GO:0004318; Molecular function: enoyl-[acyl-carrier-protein] reductase (NADH) activity.
end case
GO:0051287; Molecular function: NAD binding.
GO:0006633; Biological process: fatty acid biosynthetic process.
GO:0006633; Biological process: fatty acid biosynthetic process.
Cross-references
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| Pfam | PF07055; Eno-Rase_FAD_bd; 1; |
Features
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| From: FABV_CLOAB (Q97LU2) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 47 | 52 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | G-x-S-[STN]-x-[YF] | ||||||||
| BINDING | 74 | 75 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | [YLF]-E | ||||||||
| BINDING | 111 | 112 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | D-[AGV] | ||||||||
| BINDING | 139 | 140 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | [VLIA]-A | ||||||||
| BINDING | 274 | 276 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | [LIV]-x-T | ||||||||
| ACT_SITE | 235 | 235 | Proton donor | Y | ||||||||
| BINDING | 225 | 225 | /ligand="substrate | Y | ||||||||
| BINDING | 244 | 244 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | K | ||||||||
| SITE | 75 | 75 | Plays an important role in discriminating NADH against NADPH | E | ||||||||
Additional information
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| Size range | 389-406 amino acids |
| Related rules | None |
| Fusion | None |