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HAMAP rule MF_01838

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General rule information [?]

Accession MF_01838
Dates 11-MAR-2005 (Created)
17-FEB-2023 (Last updated, Version 27)
Name FabV_reductase
Scope(s) Bacteria
Template(s) Q62L02 (FABV_BURMA); Q9KRA3 (FABV1_VIBCH); Q97LU2 (FABV_CLOAB); Q73Q47 (FABV_TREDE); Q2P9J6 (FABV_XANOM); Q8Z9U1 (FABV_YERPE); Q9HZP8 (FABV_PSEAE); [ Recover all ]
Triggered by HAMAP; MF_01838 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier FABV
case <OC:Bacillota> or <OC:Spirochaetota>
Protein name RecName: Full=Trans-2-enoyl-CoA reductase [NADH];
Protein name RecName: Full=Enoyl-[acyl-carrier-protein] reductase [NADH];
end case
Gene name Name=fabV;

Comments [?]

case <OC:Bacillota> or <OC:Spirochaetota>
FUNCTIONInvolved in the fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to a coenzyme A (CoA).
CATALYTIC ACTIVITY Reaction=a 2,3-saturated acyl-CoA + NAD(+) = a (2E)-enoyl-CoA + H(+) + NADH; Xref=Rhea:RHEA:18177, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:58856, ChEBI:CHEBI:65111; EC=;
FUNCTIONInvolved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon- carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP).
CATALYTIC ACTIVITY Reaction=a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + H(+) + NADH; Xref=Rhea:RHEA:10240, Rhea:RHEA-COMP:9925, Rhea:RHEA- COMP:9926, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:78784, ChEBI:CHEBI:78785; EC=;
end case
PATHWAYLipid metabolism; fatty acid biosynthesis.
SIMILARITYBelongs to the TER reductase family.

Keywords [?]

Gene Ontology [?]

case <OCellular component:Bacillota> or <OC:Spirochaetota>
GO:0050343; Molecular function:trans-2-enoyl-CoA reductase (NAD+) activity
else; https://www.ebi.ac.uk/QuickGO/term/else
GO:0004318; Molecular function:enoyl-[acyl-carrier-protein] reductase (NADH) activity
end case
GO:0051287; Molecular function:NAD binding
GO:0006633; Biological process:fatty acid biosynthetic process

Cross-references [?]

Pfam PF07055; Eno-Rase_FAD_bd; 1;

Features [?]

Key From To Description Tag Condition FTGroup
BINDING 47 52 /ligand="NAD(+)"
BINDING 74 75 /ligand="NAD(+)"
BINDING 111 112 /ligand="NAD(+)"
BINDING 139 140 /ligand="NAD(+)"
BINDING 274 276 /ligand="NAD(+)"
ACT_SITE 235 235 /note="Proton donor" Y
BINDING 225 225 /ligand="substrate" Y
BINDING 244 244 /ligand="NAD(+)"
SITE 75 75 /note="Plays an important role in discriminating NADH against NADPH" E

Additional information [?]

Size range 389-406 amino acids
Related rules None
Fusion Nter: None Cter: None

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