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Annotation rule MF_01838 |
General rule information
[?]
Accession |
MF_01838 |
Dates |
11-MAR-2005 (Created) 19-NOV-2019 (Last updated, Version 23) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
case <OC:Firmicutes> or <OC:Spirochaetes>
Protein name |
RecName:
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Full=Trans-2-enoyl-CoA reductase [NADH];
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Short=TER;
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EC 1.3.1.44;
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else
Protein name |
RecName:
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Full=Enoyl-[acyl-carrier-protein] reductase [NADH];
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Short=ENR;
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EC 1.3.1.9;
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end case
case <OC:Firmicutes> or <OC:Spirochaetes>
Function |
Involved in the fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to a coenzyme A (CoA). |
Catalytic activity |
RHEA:18177: a 2,3-saturated acyl-CoA + NAD(+) = a (2E)-enoyl-CoA + H(+) + NADH
EC 1.3.1.44
|
else
Function |
Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). |
Catalytic activity |
RHEA:10240: a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + H(+) + NADH
EC 1.3.1.9
|
end case
Pathway |
Lipid metabolism; fatty acid biosynthesis. |
Subunit |
Monomer. |
Similarity |
Belongs to the TER reductase family. |
case <OC:Firmicutes> or <OC:Spirochaetes>
GO:0050343; Molecular function: trans-2-enoyl-CoA reductase (NAD+) activity.
else
GO:0004318; Molecular function: enoyl-[acyl-carrier-protein] reductase (NADH) activity.
end case
GO:0051287; Molecular function: NAD binding.
GO:0006633; Biological process: fatty acid biosynthetic process.
From: FABV_CLOAB (Q97LU2) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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NP_BIND
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47
|
|
52
|
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NAD
|
|
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G-x-S-[STN]-x-[YF]
|
|
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NP_BIND
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74
|
|
75
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NAD
|
|
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[YLF]-E
|
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NP_BIND
|
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111
|
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112
|
|
NAD
|
|
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D-[AGV]
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NP_BIND
|
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139
|
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140
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NAD
|
|
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[VLIA]-A
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NP_BIND
|
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274
|
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276
|
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NAD
|
|
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[LIV]-x-T
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ACT_SITE
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235
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235
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Proton donor
|
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Y
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BINDING
|
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225
|
|
225
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Substrate
|
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Y
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BINDING
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244
|
|
244
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NAD
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K
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SITE
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75
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75
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Plays an important role in discriminating NADH against NADPH
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E
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Additional information
[?]
Size range |
389-406 amino acids |
Related rules |
None |
Fusion |
None |