HAMAP rule MF_01838
General rule information
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| Accession | MF_01838 |
| Dates | 11-MAR-2005 (Created)
25-APR-2024 (Last updated, Version 28) |
| Name | FabV_reductase |
| Scope(s) |
Bacteria |
| Template(s) | Q62L02 (FABV_BURMA); Q9KRA3 (FABV1_VIBCH); Q97LU2 (FABV_CLOAB); Q73Q47 (FABV_TREDE); Q2P9J6 (FABV_XANOM); Q8Z9U1 (FABV_YERPE); Q9HZP8 (FABV_PSEAE); [ Recover all ] |
| Triggered by |
HAMAP; MF_01838 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | FABV |
| case <OC:Bacillota> or <OC:Spirochaetota> | |
| Protein name | RecName: Full=Trans-2-enoyl-CoA reductase [NADH]; Short=TER; EC=1.3.1.44; |
| else | |
| Protein name | RecName: Full=Enoyl-[acyl-carrier-protein] reductase [NADH]; Short=ENR; EC=1.3.1.9; |
| end case | |
| Gene name | Name=fabV; |
Comments
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| case <OC:Bacillota> or <OC:Spirochaetota> | |
| FUNCTION | Involved in the fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to a coenzyme A (CoA). |
| CATALYTIC ACTIVITY | Reaction=a 2,3-saturated acyl-CoA + NAD(+) = a (2E)-enoyl-CoA + H(+) + NADH; Xref=Rhea:RHEA:18177, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:58856, ChEBI:CHEBI:65111; EC=1.3.1.44; |
| else | |
| FUNCTION | Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon- carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). |
| CATALYTIC ACTIVITY | Reaction=a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + H(+) + NADH; Xref=Rhea:RHEA:10240, Rhea:RHEA-COMP:9925, Rhea:RHEA- COMP:9926, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:78784, ChEBI:CHEBI:78785; EC=1.3.1.9; |
| end case | |
| PATHWAY | Lipid metabolism; fatty acid biosynthesis. |
| SUBUNIT | Monomer. |
| SIMILARITY | Belongs to the TER reductase family. |
Keywords
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| Fatty acid biosynthesis |
| Fatty acid metabolism |
| Lipid metabolism |
| Lipid biosynthesis |
| NAD |
| Oxidoreductase |
Gene Ontology
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| case <OCellular component:Bacillota> or <OC:Spirochaetota> | |
| GO:0050343; Molecular function:trans-2-enoyl-CoA reductase (NADH) activity | |
| else; https://www.ebi.ac.uk/QuickGO/term/else | |
| GO:0004318; Molecular function:enoyl-[acyl-carrier-protein] reductase (NADH) activity | |
| end case | |
| GO:0051287; Molecular function:NAD binding | |
| GO:0006633; Biological process:fatty acid biosynthetic process | |
Cross-references
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| Pfam | PF07055; Eno-Rase_FAD_bd; 1; |
Features
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| From: FABV_CLOAB (Q97LU2) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 47 | 52 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
G-x-S-[STN]-x-[YF] | ||||||||
| BINDING | 74 | 75 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
[YLF]-E | ||||||||
| BINDING | 111 | 112 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
D-[AGV] | ||||||||
| BINDING | 139 | 140 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
[VLIA]-A | ||||||||
| BINDING | 274 | 276 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
[LIV]-x-T | ||||||||
| ACT_SITE | 235 | 235 | /note="Proton donor" | Y | ||||||||
| BINDING | 225 | 225 | /ligand="substrate" | Y | ||||||||
| BINDING | 244 | 244 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
K | ||||||||
| SITE | 75 | 75 | /note="Plays an important role in discriminating NADH against NADPH" | E | ||||||||
Additional information
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| Size range | 389-406 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |