HAMAP rule MF_01839
General rule information
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| Accession | MF_01839 |
| Dates | 28-JUL-2005 (Created) 19-NOV-2019 (Last updated, Version 16) |
| Name | NO_factor_SlmA |
| Scope | Bacteria; Gammaproteobacteria |
| Template | P0C093 (SLMA_ECOLI) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions. |
| Subunit | Homodimer. Interacts with FtsZ. |
| Subcellular location | Cytoplasm, nucleoid. |
| Similarity | Belongs to the nucleoid occlusion factor SlmA family. |
Keywords
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Gene Ontology
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GO:0005737; Cellular component: cytoplasm.
GO:0043590; Cellular component: bacterial nucleoid.
GO:0051302; Biological process: regulation of cell division.
GO:0043565; Molecular function: sequence-specific DNA binding.
GO:0005515; Molecular function: protein binding.
GO:0043590; Cellular component: bacterial nucleoid.
GO:0051302; Biological process: regulation of cell division.
GO:0043565; Molecular function: sequence-specific DNA binding.
GO:0005515; Molecular function: protein binding.
Cross-references
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Computed features
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| General | Coiled_coil; -; 0-1; trigger=yes; |
Additional information
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| Size range | 195-218 amino acids |
| Related rules | None |
| Fusion | None |
| Comments | Although SlmA is a member of the TetR family, it does not exert its function via transcription regulation (PubMed:21113127). |