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HAMAP rule MF_01839

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General rule information [?]

Accession MF_01839
Dates 28-JUL-2005 (Created)
19-NOV-2019 (Last updated, Version 16)
Name NO_factor_SlmA
Bacteria; Gammaproteobacteria
Template P0C093 (SLMA_ECOLI)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Nucleoid occlusion factor SlmA;
Gene name

Comments [?]

Function Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions.
Subunit Homodimer. Interacts with FtsZ.
Subcellular location Cytoplasm, nucleoid.
Similarity Belongs to the nucleoid occlusion factor SlmA family.

Keywords [?]

Gene Ontology [?]

GO:0005737; Cellular component: cytoplasm.
GO:0043590; Cellular component: bacterial nucleoid.
GO:0051302; Biological process: regulation of cell division.
GO:0043565; Molecular function: sequence-specific DNA binding.
GO:0005515; Molecular function: protein binding.

Cross-references [?]

PS50977; HTH_TETR_2; 1; trigger=PRU00335;
Pfam PF00440; TetR_N; 1;

Computed features [?]

General Coiled_coil; -; 0-1; trigger=yes;

Additional information [?]

Size range 195-218 amino acids
Related rules None
Fusion None
Comments Although SlmA is a member of the TetR family, it does not exert its function via transcription regulation (PubMed:21113127).