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HAMAP rule MF_01839

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General rule information [?]

Accession MF_01839
Dates 28-JUL-2005 (Created)
19-NOV-2019 (Last updated, Version 16)
Name NO_factor_SlmA
Scope(s) Bacteria
Template(s) P0C093 (SLMA_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01839 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier SLMA
Protein name RecName: Full=Nucleoid occlusion factor SlmA;
Gene name Name=slmA;

Comments [?]

FUNCTIONRequired for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions.
SUBUNITHomodimer. Interacts with FtsZ.
SUBCELLULAR LOCATIONCytoplasm, nucleoid.
SIMILARITYBelongs to the nucleoid occlusion factor SlmA family.

Keywords [?]

Gene Ontology [?]

GO:0005737; Cellular component:cytoplasm
GO:0043590; Cellular component:bacterial nucleoid
GO:0051302; Biological process:regulation of cell division
GO:0043565; Molecular function:sequence-specific DNA binding
GO:0005515; Molecular function:protein binding

Cross-references [?]

Pfam PF00440; TetR_N; 1;
General Coiled_coil; -; 0-1;

Features [?]

Additional information [?]

Size range 195-218 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments Although SlmA is a member of the TetR family, it does not exert its function via transcription regulation (PubMed:21113127).

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