HAMAP rule MF_01842
General rule information
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| Accession | MF_01842 |
| Dates | 15-DEC-2005 (Created)
19-NOV-2022 (Last updated, Version 16) |
| Name | Archaemetzincin |
| Scope(s) |
Archaea |
| Template(s) | Q400G9 (AMZ1_HUMAN); Q8TXW1 (AMZA_METKA); O29917 (AMZA_ARCFU); [ Recover all ] |
| Triggered by |
HAMAP; MF_01842 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | AMZA |
| Protein name | RecName: Full=Archaemetzincin; EC=3.4.-.-; |
| Gene name | Name=amzA; |
Comments
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| FUNCTION | Probable zinc metalloprotease whose natural substrate is unknown. |
| COFACTOR | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit. One is catalytic, whereas the other seems to have a structural role.; |
| SUBUNIT | Monomer. |
| SIMILARITY | Belongs to the peptidase M54 family. |
Keywords
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Gene Ontology
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| GO:0008237; Molecular function:metallopeptidase activity |
| GO:0006508; Biological process:proteolysis |
| GO:0008270; Molecular function:zinc ion binding |
Cross-references
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| PROSITE | PS00142; ZINC_PROTEASE; 1; |
| Pfam | PF07998; Peptidase_M54; 1; |
| PIRSF | PIRSF005785; Zn-prot_arch; 1; |
Features
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| From: AMZA_METKA (Q8TXW1) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 126 | 126 | /note="Proton acceptor" | E | ||||||||
| BINDING | 125 | 125 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" /ligand_note="catalytic" |
H | ||||||||
| BINDING | 129 | 129 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" /ligand_note="catalytic" |
H | ||||||||
| BINDING | 135 | 135 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" /ligand_note="catalytic" |
H | ||||||||
| BINDING | 136 | 136 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" |
C | ||||||||
| BINDING | 141 | 141 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" |
C | ||||||||
| BINDING | 160 | 160 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" |
C | ||||||||
| BINDING | 163 | 163 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" |
C | ||||||||
Additional information
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| Size range | 155-192 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | Although it has not been proved in prokaryotes, its function as metalloprotease is probable due to the strong similarities with the AMZ1 and AMZ2 enzymes. See: RX PubMed=15972818; DOI=10.1074/jbc.M504533200; RA Diaz-Perales A., Quesada V., Peinado J.R., Ugalde A.P., Alvarez J., RA Suarez M.F., Gomis-Rueth X., Lopez-Otin C.; RT "Identification and characterization of human archaemetzincin-1 and - RT 2, two novel members of a family of metalloproteases widely RT distributed in archae."; RL J. BiolQ400G9. Chem. 280:30367-30375(2005). The family has been identified in Archaea and described in: RX PubMed=12746556; RA Gomis-Rueth F.X.; RT "Structural aspects of the metzincin clan of metalloendopeptidases."; RL Mol. Biotechnol. 24:157-202(2003). |