HAMAP rule MF_01870
General rule information
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Accession | MF_01870 |
Dates | 3-AUG-2009 (Created) 19-NOV-2019 (Last updated, Version 12) |
Name | ArnD |
Scope | Bacteria; Gammaproteobacteria |
Template | P76472 (ARND_ECOLI) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Catalyzes the deformylation of 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. |
Catalytic activity | RHEA:27734: 4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + H2O = 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + formate
EC 3.5.1.n3 |
Pathway | Glycolipid biosynthesis; 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate biosynthesis; 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate from UDP-4-deoxy-4-formamido-beta-L-arabinose and undecaprenyl phosphate: step 2/2. |
Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. | |
Similarity | Belongs to the polysaccharide deacetylase family. ArnD deformylase subfamily. |
Keywords
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Antibiotic resistance
Hydrolase
Lipid A biosynthesis
Lipid biosynthesis
Lipid metabolism
Lipopolysaccharide biosynthesis
Hydrolase
Lipid A biosynthesis
Lipid biosynthesis
Lipid metabolism
Lipopolysaccharide biosynthesis
Gene Ontology
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GO:0016811; Molecular function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides.
GO:0009245; Biological process: lipid A biosynthetic process.
GO:0009245; Biological process: lipid A biosynthetic process.
Cross-references
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Additional information
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Size range | 276-310 amino acids |
Related rules | None |
Fusion | None |