HAMAP rule MF_01870

General rule information [?]

Accession	MF_01870
Dates	3-AUG-2009 (Created) 19-NOV-2019 (Last updated, Version 12)

Name

ArnD

Scope

Bacteria; Gammaproteobacteria

Template

P76472 (ARND_ECOLI)

Triggered by

HAMAP; MF_01870 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

ARND

Protein name

RecName:		Full=Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD;
		EC 3.5.1.n3;

Gene name

arnD

Comments [?]

Function	Catalyzes the deformylation of 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
Catalytic activity	RHEA:27734: 4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + H2O = 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + formate EC 3.5.1.n3
Pathway	Glycolipid biosynthesis; 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate biosynthesis; 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate from UDP-4-deoxy-4-formamido-beta-L-arabinose and undecaprenyl phosphate: step 2/2.
	Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis.
Similarity	Belongs to the polysaccharide deacetylase family. ArnD deformylase subfamily.

Keywords [?]

Antibiotic resistance
Hydrolase
Lipid A biosynthesis
Lipid biosynthesis
Lipid metabolism
Lipopolysaccharide biosynthesis

Gene Ontology [?]

GO:0016811; Molecular function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides.
GO:0009245; Biological process: lipid A biosynthetic process.

Cross-references [?]

Pfam	PF01522; Polysacc_deac_1; 1;
PROSITE	PS51677; NODB; 1; trigger=PRU01014;

Additional information [?]

Size range	276-310 amino acids
Related rules	None
Fusion	None

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