HAMAP rule MF_01870
General rule information
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Accession | MF_01870 |
Dates | 3-AUG-2009 (Created)
7-MAY-2024 (Last updated, Version 14) |
Name | ArnD |
Scope(s) |
Bacteria Gammaproteobacteria |
Template(s) | P76472 (ARND_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_01870 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | ARND |
Protein name | RecName: Full=Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; EC=3.5.1.n3; |
Gene name | Name=arnD; |
Comments
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FUNCTION | Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. |
CATALYTIC ACTIVITY | Reaction=4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa- cis-undecaprenyl phosphate + H2O = 4-amino-4-deoxy-alpha-L- arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + formate; Xref=Rhea:RHEA:27734, ChEBI:CHEBI:15377, ChEBI:CHEBI:15740, ChEBI:CHEBI:58909, ChEBI:CHEBI:60463; EC=3.5.1.n3; |
PATHWAY | Glycolipid biosynthesis; 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate biosynthesis; 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate from UDP-4-deoxy-4-formamido-beta-L-arabinose and undecaprenyl phosphate: step 2/2. |
PATHWAY | Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. |
SIMILARITY | Belongs to the polysaccharide deacetylase family. ArnD deformylase subfamily. |
Keywords
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Antibiotic resistance |
Hydrolase |
Lipid A biosynthesis |
Lipid biosynthesis |
Lipid metabolism |
Lipopolysaccharide biosynthesis |
Gene Ontology
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GO:0016811; Molecular function:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
GO:0009245; Biological process:lipid A biosynthetic process |
GO:0009103; Biological process:lipopolysaccharide biosynthetic process |
GO:0036108; Biological process:4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process |
Cross-references
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Features
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Additional information
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Size range | 276-310 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |