HAMAP rule MF_01870

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_01870
Accession	MF_01870
Dates	03-AUG-2009 (Created) 07-MAY-2024 (Last updated, Version 15)
Name	ArnD
Scope(s)	Bacteria Gammaproteobacteria
Template(s)	P76472; [ Recover all ]
Triggered by	HAMAP; MF_01870 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	ARND
Protein name	RecName: Full=Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; EC=3.5.1.n3;
Gene name	Name=arnD;

Comments [?]

FUNCTION	Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
CATALYTIC ACTIVITY	Reaction=4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa- cis-undecaprenyl phosphate + H2O = 4-amino-4-deoxy-alpha-L- arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + formate; Xref=Rhea:RHEA:27734, ChEBI:CHEBI:15377, ChEBI:CHEBI:15740, ChEBI:CHEBI:58909, ChEBI:CHEBI:60463; EC=3.5.1.n3;
PATHWAY	Glycolipid biosynthesis; 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate biosynthesis; 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate from UDP-4-deoxy-4-formamido-beta-L-arabinose and undecaprenyl phosphate: step 2/2.
PATHWAY	Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis.
SIMILARITY	Belongs to the polysaccharide deacetylase family. ArnD deformylase subfamily.

Keywords [?]

Gene Ontology [?]

GO:0016811; Molecular function:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

GO:0009245; Biological process:lipid A biosynthetic process

GO:0009103; Biological process:lipopolysaccharide biosynthetic process

GO:0036108; Biological process:4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process

Cross-references [?]

Pfam	PF01522; Polysacc_deac_1; 1;
PROSITE	PS51677; NODB; 1;

Features [?]

Additional information [?]