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HAMAP rule MF_01876

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General rule information [?]

Accession MF_01876
Dates 25-NOV-2009 (Created)
19-NOV-2022 (Last updated, Version 13)
Name PsiMP_glycosidase
Templates P33025 (PSUG_ECOLI); Q9X1H5 (PSUG_THEMA): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Pseudouridine-5'-phosphate glycosidase;
Short=PsiMP glycosidase;
Gene name

Comments [?]

Function Catalyzes the reversible cleavage of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway.
Catalytic activity RHEA:18337: D-ribose 5-phosphate + uracil = H2O + psi-UMP
Cofactor Mn(2+)
Note: Binds 1 Mn(2+) ion per subunit.
Subunit Homotrimer.
Similarity Belongs to the pseudouridine-5'-phosphate glycosidase family.

Keywords [?]

Gene Ontology [?]

GO:0004730; Molecular function: pseudouridylate synthase activity.
GO:0046113; Biological process: nucleobase catabolic process.

Cross-references [?]

Pfam PF04227; Indigoidine_A; 1;

Features [?]

From: PSUG_ECOLI (P33025)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     147     149       /ligand="substrate     S-x-D  
ACT_SITE     31     31       Proton donor     E  
ACT_SITE     166     166       Nucleophile     K  
BINDING     145     145       /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035     D  
BINDING     93     93       /ligand="substrate     K  
BINDING     113     113       /ligand="substrate     [VA]  

Additional information [?]

Size range 270-369 amino acids
Related rules None
Fusion None