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HAMAP rule MF_01876

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General rule information [?]

Accession MF_01876
Dates 25-NOV-2009 (Created)
19-NOV-2022 (Last updated, Version 13)
Name PsiMP_glycosidase
Scope(s) Bacteria
Template(s) P33025 (PSUG_ECOLI); Q9X1H5 (PSUG_THEMA); [ Recover all ]
Triggered by HAMAP; MF_01876 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PSUG
Protein name RecName: Full=Pseudouridine-5'-phosphate glycosidase;
                 Short=PsiMP glycosidase;
                 EC=4.2.1.70;
Gene name Name=psuG;

Comments [?]

FUNCTIONCatalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway.
CATALYTIC ACTIVITY Reaction=D-ribose 5-phosphate + uracil = H2O + psi-UMP; Xref=Rhea:RHEA:18337, ChEBI:CHEBI:15377, ChEBI:CHEBI:17568, ChEBI:CHEBI:58380, ChEBI:CHEBI:78346; EC=4.2.1.70;
COFACTOR Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 1 Mn(2+) ion per subunit.;
SUBUNITHomotrimer.
SIMILARITYBelongs to the pseudouridine-5'-phosphate glycosidase family.

Keywords [?]


Gene Ontology [?]

GO:0004730; Molecular function:pseudouridylate synthase activity
GO:0046113; Biological process:nucleobase catabolic process

Cross-references [?]

Pfam PF04227; Indigoidine_A; 1;

Features [?]

From: PSUG_ECOLI (P33025)
Key From To Description Tag Condition FTGroup
BINDING 147 149 /ligand="substrate" S-x-D
ACT_SITE 31 31 /note="Proton donor" E
ACT_SITE 166 166 /note="Nucleophile" K
BINDING 145 145 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"
D
BINDING 93 93 /ligand="substrate" K
BINDING 113 113 /ligand="substrate" [VA]

Additional information [?]

Size range 270-369 amino acids
Related rules None
Fusion Nter: None Cter: None



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