HAMAP rule MF_01876

General rule information [?]

Accession	MF_01876
Dates	25-NOV-2009 (Created) 19-NOV-2022 (Last updated, Version 13)

Name	PsiMP_glycosidase

Scope

Bacteria

Templates

P33025 (PSUG_ECOLI); Q9X1H5 (PSUG_THEMA): [Recover all]

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

PSUG

Protein name

RecName:		Full=Pseudouridine-5'-phosphate glycosidase;
		Short=PsiMP glycosidase;
		EC 4.2.1.70;

Gene name

psuG

Comments [?]

Function	Catalyzes the reversible cleavage of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway.
Catalytic activity	RHEA:18337: D-ribose 5-phosphate + uracil = H2O + psi-UMP EC 4.2.1.70
Cofactor	Mn(2+) Note: Binds 1 Mn(2+) ion per subunit.
Subunit	Homotrimer.
Similarity	Belongs to the pseudouridine-5'-phosphate glycosidase family.

Keywords [?]

Gene Ontology [?]

GO:0004730; Molecular function: pseudouridylate synthase activity.
GO:0046113; Biological process: nucleobase catabolic process.

Cross-references [?]

Pfam	PF04227; Indigoidine_A; 1;

Features [?]

From: PSUG_ECOLI (P33025)

Key From To Description Tag Condition FTGroup

BINDING 147 149 /ligand="substrate S-x-D

ACT_SITE 31 31 Proton donor E

ACT_SITE 166 166 Nucleophile K

BINDING 145 145 /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035 D

BINDING 93 93 /ligand="substrate K

BINDING 113 113 /ligand="substrate [VA]

Additional information [?]