HAMAP rule MF_01876
General rule information
[?]
Accession | MF_01876 |
Dates | 25-NOV-2009 (Created) 19-NOV-2022 (Last updated, Version 13) |
Name | PsiMP_glycosidase |
Scope | Bacteria |
Templates | P33025 (PSUG_ECOLI); Q9X1H5 (PSUG_THEMA): [Recover all] |
Triggered by |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Identifier |
|
Protein name |
|
Gene name |
|
Comments
[?]
Function | Catalyzes the reversible cleavage of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway. |
Catalytic activity | RHEA:18337: D-ribose 5-phosphate + uracil = H2O + psi-UMP
EC 4.2.1.70 |
Cofactor | Mn(2+) Note: Binds 1 Mn(2+) ion per subunit. |
Subunit | Homotrimer. |
Similarity | Belongs to the pseudouridine-5'-phosphate glycosidase family. |
Keywords
[?]
Gene Ontology
[?]
GO:0004730; Molecular function: pseudouridylate synthase activity.
GO:0046113; Biological process: nucleobase catabolic process.
GO:0046113; Biological process: nucleobase catabolic process.
Cross-references
[?]
Pfam | PF04227; Indigoidine_A; 1; |
Features
[?]
From: PSUG_ECOLI (P33025) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 147 | 149 | /ligand="substrate | S-x-D | ||||||||
ACT_SITE | 31 | 31 | Proton donor | E | ||||||||
ACT_SITE | 166 | 166 | Nucleophile | K | ||||||||
BINDING | 145 | 145 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035 | D | ||||||||
BINDING | 93 | 93 | /ligand="substrate | K | ||||||||
BINDING | 113 | 113 | /ligand="substrate | [VA] |
Additional information
[?]
Size range | 270-369 amino acids |
Related rules | None |
Fusion | None |