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HAMAP rule MF_01876
General rule information
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| Accession | MF_01876 |
| Dates | 25-NOV-2009 (Created)
28-NOV-2023 (Last updated, Version 14) |
| Name | PsiMP_glycosidase |
| Scope(s) |
Bacteria |
| Template(s) | P33025 (PSUG_ECOLI); Q9X1H5 (PSUG_THEMA); [ Recover all ] |
| Triggered by |
HAMAP; MF_01876 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | PSUG |
| Protein name | RecName: Full=Pseudouridine-5'-phosphate glycosidase; Short=PsiMP glycosidase; EC=4.2.1.70; |
| Gene name | Name=psuG; |
Comments
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| FUNCTION | Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway. |
| CATALYTIC ACTIVITY | Reaction=D-ribose 5-phosphate + uracil = H2O + psi-UMP; Xref=Rhea:RHEA:18337, ChEBI:CHEBI:15377, ChEBI:CHEBI:17568, ChEBI:CHEBI:58380, ChEBI:CHEBI:78346; EC=4.2.1.70; |
| COFACTOR | Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 1 Mn(2+) ion per subunit.; |
| SUBUNIT | Homotrimer. |
| SIMILARITY | Belongs to the pseudouridine-5'-phosphate glycosidase family. |
Keywords
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Gene Ontology
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| GO:0004730; Molecular function:pseudouridylate synthase activity |
| GO:0046113; Biological process:nucleobase catabolic process |
Cross-references
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| Pfam | PF04227; Indigoidine_A; 1; |
Features
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| From: PSUG_ECOLI (P33025) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 147 | 149 | /ligand="substrate" | S-x-D | ||||||||
| ACT_SITE | 31 | 31 | /note="Proton donor" | E | ||||||||
| ACT_SITE | 166 | 166 | /note="Nucleophile" | K | ||||||||
| BINDING | 145 | 145 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" |
D | ||||||||
| BINDING | 93 | 93 | /ligand="substrate" | K | ||||||||
| BINDING | 113 | 113 | /ligand="substrate" | [VA] | ||||||||
Additional information
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| Size range | 270-369 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |