HAMAP rule MF_01876

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_01876
Accession	MF_01876
Dates	25-NOV-2009 (Created) 09-SEP-2024 (Last updated, Version 17)
Name	PsiMP_glycosidase
Scope(s)	Bacteria
Template(s)	P33025; Q9X1H5; [ Recover all ]
Triggered by	HAMAP; MF_01876 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	PSUG
Protein name	RecName: Full=Pseudouridine-5'-phosphate glycosidase; Short=PsiMP glycosidase; EC=4.2.1.70;
Gene name	Name=psuG;

Comments [?]

FUNCTION	Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway.
CATALYTIC ACTIVITY	Reaction=D-ribose 5-phosphate + uracil = psi-UMP + H2O; Xref=Rhea:RHEA:18337, ChEBI:CHEBI:15377, ChEBI:CHEBI:17568, ChEBI:CHEBI:58380, ChEBI:CHEBI:78346; EC=4.2.1.70;
COFACTOR	Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 1 Mn(2+) ion per subunit.;
SUBUNIT	Homotrimer.
SIMILARITY	Belongs to the pseudouridine-5'-phosphate glycosidase family.

Keywords [?]

Gene Ontology [?]

GO:0004730; Molecular function:pseudouridylate synthase activity

GO:0046113; Biological process:nucleobase catabolic process

Cross-references [?]

Pfam	PF04227; Indigoidine_A; 1;

Features [?]

From: PSUG_ECOLI (P33025)

Key

From

Description

Tag

Condition

FTGroup

BINDING

147

149

/ligand="substrate"

S-x-D

ACT_SITE

/note="Proton donor"

ACT_SITE

166

/note="Nucleophile"

BINDING

145

/ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"

BINDING

/ligand="substrate"

BINDING

113

/ligand="substrate"

[VA]

Additional information [?]