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Annotation rule MF_01885 |
Accession | MF_01885 |
Dates | 21-OCT-2010 (Created) 19-NOV-2019 (Last updated, Version 8) |
Name | tRNA_methyltr_TrmL |
Scope | Bacteria |
Templates | P0AGJ7 (TRML_ECOLI); P44868 (TRML_HAEIN); Q74Y93 (TRML_YERPE): [Recover all] |
Triggered by |
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Function | Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide. |
Function | Could methylate the ribose at the nucleotide 34 wobble position in tRNA. |
Catalytic activity | RHEA:43084: cytidine(34) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine
EC 2.1.1.207 |
RHEA:43088: 5-carboxymethylaminomethyluridine(34) in tRNA(Leu) + S-adenosyl-L-methionine = 5-carboxymethylaminomethyl-2'-O-methyluridine(34) in tRNA(Leu) + H(+) + S-adenosyl-L-homocysteine
EC 2.1.1.207 |
Subunit | Homodimer. |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily. |
Pfam | PF00588; SpoU_methylase; 1; |
TIGRFAMs | TIGR00185; RRNA_methyl_2; 1; |
PIRSF | PIRSF029256; SpoU_TrmH_prd; 1; |
From: TRML_HAEIN (P44868) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING (Optional) | 78 | 78 | S-adenosyl-L-methionine; via carbonyl oxygen | [ILVM] | ||||||||
BINDING (Optional) | 100 | 100 | S-adenosyl-L-methionine; via amide nitrogen | G | ||||||||
BINDING (Optional) | 122 | 122 | S-adenosyl-L-methionine; via amide nitrogen and carbonyl oxygen | [ILVM] | ||||||||
BINDING (Optional) | 130 | 130 | S-adenosyl-L-methionine | S |
Size range | 140-230 amino acids |
Related rules | None |
Fusion | None |