HAMAP rule MF_01887

General rule information [?]

Accession	MF_01887
Dates	8-NOV-2010 (Created) 1-JUN-2023 (Last updated, Version 13)

Name	23SrRNA_methyltr_B

Scope

Bacteria; Pseudomonadota

Template

P63177 (RLMB_ECOLI)

Triggered by

HAMAP; MF_01887 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

RLMB

Protein name

RecName:		Full=23S rRNA (guanosine-2'-O-)-methyltransferase RlmB;
		EC 2.1.1.185;
AltName:		Full=23S rRNA (guanosine2251 2'-O)-methyltransferase;
AltName:		Full=23S rRNA Gm2251 2'-O-methyltransferase;

Gene name

rlmB

Comments [?]

Function	Specifically methylates the ribose of guanosine 2251 in 23S rRNA.
Catalytic activity	RHEA:24140: guanosine(2251) in 23S rRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(2251) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine EC 2.1.1.185

case <OC:Enterobacterales>

Subunit

Homodimer.

end case

Subcellular location	Cytoplasm.
Similarity	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. RlmB subfamily.

Keywords [?]

Cytoplasm
Methyltransferase
rRNA processing
S-adenosyl-L-methionine
Transferase

Gene Ontology [?]

GO:0070039; Molecular function: rRNA (guanosine-2'-O-)-methyltransferase activity.
GO:0006364; Biological process: rRNA processing.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam	PF00588; SpoU_methylase; 1;
	PF08032; SpoU_sub_bind; 1;
NCBIfam	TIGR00186; RRNA_methyl_3; 1;

Features [?]

From: RLMB_ECOLI (P63177)

Key From To Description Tag Condition FTGroup

BINDING 196 196 /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 G

BINDING 216 216 /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 [IL]

BINDING 225 225 /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 [LM]

Additional information [?]

Size range	231-284 amino acids
Related rules	None
Fusion	None

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