HAMAP rule MF_01887
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_01887 |
| Accession | MF_01887 |
| Dates | 08-NOV-2010 (Created)
02-SEP-2024 (Last updated, Version 15) |
| Name | 23SrRNA_methyltr_B |
| Scope(s) |
Bacteria Pseudomonadota |
| Template(s) | P63177; [ Recover all ] |
| Triggered by |
HAMAP; MF_01887 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | RLMB |
| Protein name | RecName: Full=23S rRNA (guanosine-2'-O-)-methyltransferase RlmB; EC=2.1.1.185; AltName: Full=23S rRNA (guanosine2251 2'-O)-methyltransferase; AltName: Full=23S rRNA Gm2251 2'-O-methyltransferase; |
| Gene name | Name=rlmB; |
Comments
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| FUNCTION | Specifically methylates the ribose of guanosine 2251 in 23S rRNA. |
| CATALYTIC ACTIVITY | Reaction=guanosine(2251) in 23S rRNA + S-adenosyl-L-methionine = 2'-O- methylguanosine(2251) in 23S rRNA + S-adenosyl-L-homocysteine + H(+); Xref=Rhea:RHEA:24140, Rhea:RHEA-COMP:10239, Rhea:RHEA-COMP:10241, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74269, ChEBI:CHEBI:74445; EC=2.1.1.185; |
| case <OC:Enterobacterales> | |
| SUBUNIT | Homodimer. |
| end case | |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. RlmB subfamily. |
Keywords
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Gene Ontology
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| GO:0070039; Molecular function:rRNA (guanosine-2'-O-)-methyltransferase activity |
| GO:0006364; Biological process:rRNA processing |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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| Pfam | PF00588; SpoU_methylase; 1; |
| Pfam | PF08032; SpoU_sub_bind; 1; |
| NCBIfam | TIGR00186; RRNA_methyl_3; 1; |
Features
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| From: RLMB_ECOLI (P63177) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 196 | 196 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
G | ||||||||
| BINDING | 216 | 216 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
[IL] | ||||||||
| BINDING | 225 | 225 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
[LM] | ||||||||
Additional information
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| Size range | 231-284 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |