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HAMAP rule MF_01893

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General rule information [?]

Accession MF_01893
Dates 3-MAR-2011 (Created)
1-JUN-2023 (Last updated, Version 8)
Name Pus10_arch
Scope(s) Archaea
Template(s) Q8U1R6 (PUS10_PYRFU); Q60346 (PUS10_METJA); [ Recover all ]
Triggered by HAMAP; MF_01893 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PUS10
Protein name RecName: Full=tRNA pseudouridine synthase Pus10;
AltName: Full=tRNA pseudouridine 54/55 synthase;
                 Short=Psi54/55 synthase;
Gene name Name=pus10;

Comments [?]

FUNCTIONResponsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.
CATALYTIC ACTIVITY Reaction=uridine(54) in tRNA = pseudouridine(54) in tRNA; Xref=Rhea:RHEA:57876, Rhea:RHEA-COMP:10193, Rhea:RHEA-COMP:14141, ChEBI:CHEBI:65314, ChEBI:CHEBI:65315;
CATALYTIC ACTIVITY Reaction=uridine(55) in tRNA = pseudouridine(55) in tRNA; Xref=Rhea:RHEA:42532, Rhea:RHEA-COMP:10101, Rhea:RHEA-COMP:10102, ChEBI:CHEBI:65314, ChEBI:CHEBI:65315; EC=;
SIMILARITYBelongs to the pseudouridine synthase Pus10 family.

Keywords [?]

Gene Ontology [?]

GO:0009982; Molecular function:pseudouridine synthase activity
GO:0031119; Biological process:tRNA pseudouridine synthesis

Cross-references [?]

Pfam PF02926; THUMP; 1;
NCBIfam TIGR01213; TIGR01213; 1;

Features [?]

From: PUS10_PYRFU (Q8U1R6)
Key From To Description Tag Condition FTGroup
ACT_SITE 210 210 /note="Nucleophile" D
BINDING 274 274 /ligand="substrate" Y
BINDING 346 346 /ligand="substrate" Y

Additional information [?]

Size range 357-519 amino acids
Related rules None
Fusion Nter: None Cter: None

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