HAMAP rule MF_01893
General rule information
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| Accession | MF_01893 |
| Dates | 3-MAR-2011 (Created)
1-JUN-2023 (Last updated, Version 8) |
| Name | Pus10_arch |
| Scope(s) |
Archaea |
| Template(s) | Q8U1R6 (PUS10_PYRFU); Q60346 (PUS10_METJA); [ Recover all ] |
| Triggered by |
HAMAP; MF_01893 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | PUS10 |
| Protein name | RecName: Full=tRNA pseudouridine synthase Pus10; EC=5.4.99.25; AltName: Full=tRNA pseudouridine 54/55 synthase; Short=Psi54/55 synthase; |
| Gene name | Name=pus10; |
Comments
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| FUNCTION | Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs. |
| CATALYTIC ACTIVITY | Reaction=uridine(54) in tRNA = pseudouridine(54) in tRNA; Xref=Rhea:RHEA:57876, Rhea:RHEA-COMP:10193, Rhea:RHEA-COMP:14141, ChEBI:CHEBI:65314, ChEBI:CHEBI:65315; |
| CATALYTIC ACTIVITY | Reaction=uridine(55) in tRNA = pseudouridine(55) in tRNA; Xref=Rhea:RHEA:42532, Rhea:RHEA-COMP:10101, Rhea:RHEA-COMP:10102, ChEBI:CHEBI:65314, ChEBI:CHEBI:65315; EC=5.4.99.25; |
| SIMILARITY | Belongs to the pseudouridine synthase Pus10 family. |
Keywords
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Gene Ontology
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| GO:0009982; Molecular function:pseudouridine synthase activity |
| GO:0031119; Biological process:tRNA pseudouridine synthesis |
Cross-references
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Features
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| From: PUS10_PYRFU (Q8U1R6) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 210 | 210 | /note="Nucleophile" | D | ||||||||
| BINDING | 274 | 274 | /ligand="substrate" | Y | ||||||||
| BINDING | 346 | 346 | /ligand="substrate" | Y | ||||||||
Additional information
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| Size range | 357-519 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |