HAMAP rule MF_01896

General rule information [?]

Accession	MF_01896
Dates	29-APR-2011 (Created) 19-NOV-2019 (Last updated, Version 6)
Name	DNA_gyrase_inhibitor
Scope(s)	Bacteria Enterobacterales
Template(s)	P33012 (SBMC_ECOLI); [ Recover all ]
Triggered by	HAMAP; MF_01896 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	SBMC
Protein name	RecName: Full=DNA gyrase inhibitor;
Gene name	Name=sbmC;

Comments [?]

FUNCTION	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell.
SUBUNIT	Interacts with DNA gyrase.
SUBCELLULAR LOCATION	Cytoplasm.
SIMILARITY	Belongs to the DNA gyrase inhibitor family.

Keywords [?]

Gene Ontology [?]

GO:0008657; Molecular function:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity

GO:2000372; Biological process:negative regulation of DNA topoisomerase (ATP-hydrolyzing) activity

GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam	PF06445; GyrI-like; 1;

Features [?]

Additional information [?]