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| Annotation rule MF_01896 |
General rule information
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| Accession | MF_01896 |
| Dates | 29-APR-2011 (Created) 19-NOV-2019 (Last updated, Version 6) |
| Name | DNA_gyrase_inhibitor |
| Scope | Bacteria; Enterobacterales |
| Template | P33012 (SBMC_ECOLI) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell. |
| Subunit | Interacts with DNA gyrase. |
| Subcellular location | Cytoplasm. |
| Similarity | Belongs to the DNA gyrase inhibitor family. |
Keywords
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Gene Ontology
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GO:0008657; Molecular function: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity.
GO:2000372; Biological process: negative regulation of DNA topoisomerase (ATP-hydrolyzing) activity.
GO:0005737; Cellular component: cytoplasm.
GO:2000372; Biological process: negative regulation of DNA topoisomerase (ATP-hydrolyzing) activity.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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| Pfam | PF06445; GyrI-like; 1; |
Additional information
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| Size range | 120-173 amino acids |
| Related rules | None |
| Fusion | None |