HAMAP rule MF_01896

General rule information [?]

Accession	MF_01896
Dates	29-APR-2011 (Created) 19-NOV-2019 (Last updated, Version 6)

Name	DNA_gyrase_inhibitor

Scope

Bacteria; Enterobacterales

Template

P33012 (SBMC_ECOLI)

Triggered by

HAMAP; MF_01896 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

SBMC

Protein name

RecName:

Full=DNA gyrase inhibitor;

Gene name

sbmC

Comments [?]

Function	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell.
Subunit	Interacts with DNA gyrase.
Subcellular location	Cytoplasm.
Similarity	Belongs to the DNA gyrase inhibitor family.

Keywords [?]

Cytoplasm
Stress response

Gene Ontology [?]

GO:0008657; Molecular function: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity.
GO:2000372; Biological process: negative regulation of DNA topoisomerase (ATP-hydrolyzing) activity.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam	PF06445; GyrI-like; 1;

Additional information [?]

Size range	120-173 amino acids
Related rules	None
Fusion	None

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