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HAMAP rule MF_01896

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General rule information [?]

Accession MF_01896
Dates 29-APR-2011 (Created)
19-NOV-2019 (Last updated, Version 6)
Name DNA_gyrase_inhibitor
Bacteria; Enterobacterales
Template P33012 (SBMC_ECOLI)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=DNA gyrase inhibitor;
Gene name

Comments [?]

Function Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell.
Subunit Interacts with DNA gyrase.
Subcellular location Cytoplasm.
Similarity Belongs to the DNA gyrase inhibitor family.

Keywords [?]

Gene Ontology [?]

GO:0008657; Molecular function: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity.
GO:2000372; Biological process: negative regulation of DNA topoisomerase (ATP-hydrolyzing) activity.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF06445; GyrI-like; 1;

Additional information [?]

Size range 120-173 amino acids
Related rules None
Fusion None