HAMAP rule MF_01902
General rule information
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| Accession | MF_01902 |
| Dates | 28-JUN-2005 (Created)
28-NOV-2023 (Last updated, Version 22) |
| Name | DNApol_error_prone |
| Scope(s) |
Bacteria Actinomycetota Planctomycetota Pseudomonadota |
| Template(s) | P9WNT5 (DNAE2_MYCTU); Q9A3J3 (DNAE2_CAUVC); [ Recover all ] |
| Triggered by |
HAMAP; MF_01902 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | DNAE2 |
| Protein name | RecName: Full=Error-prone DNA polymerase; EC=2.7.7.7; |
| Gene name | Name=dnaE2; |
Comments
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| FUNCTION | DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. |
| CATALYTIC ACTIVITY | Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339, Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, ChEBI:CHEBI:173112; EC=2.7.7.7; |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the DNA polymerase type-C family. DnaE2 subfamily. |
Keywords
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| Cytoplasm |
| DNA damage |
| DNA repair |
| DNA replication |
| DNA-directed DNA polymerase |
| Nucleotidyltransferase |
| Transferase |
Gene Ontology
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| GO:0003887; Molecular function:DNA-directed DNA polymerase activity |
| GO:0006281; Biological process:DNA repair |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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| Pfam | PF07733; DNA_pol3_alpha; 1; |
| Pfam | PF02811; PHP; 1; |
| Pfam | PF01336; tRNA_anti; 1; |
| NCBIfam | TIGR00594; Polc; 1; |
Features
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Additional information
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| Size range | 1024-1195 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |