HAMAP rule MF_01903

General rule information [?]

Accession	MF_01903
Dates	6-DEC-2005 (Created) 26-JAN-2023 (Last updated, Version 32)

Name

XGPRT

Scope

Bacteria; Pseudomonadota

Templates

P0A9M5 (XGPT_ECOLI); Q8ZC05 (XGPT_YERPE): [Recover all]

Triggered by

HAMAP; MF_01903 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

XGPT

Protein name

RecName:		Full=Xanthine-guanine phosphoribosyltransferase;
		Short=XGPRT;
		EC 2.4.2.-;
		EC 2.4.2.22;
AltName:		Full=Xanthine phosphoribosyltransferase;

Gene name

gpt

Comments [?]

Function	Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-monophosphate) and XMP (xanthosine 5'-monophosphate), with the release of PPi. To a lesser extent, also acts on hypoxanthine.
Catalytic activity	RHEA:25424: diphosphate + GMP = 5-phospho-alpha-D-ribose 1-diphosphate + guanine PhysiologicalDirection=right-to-left (RHEA:25426)
	RHEA:10800: diphosphate + XMP = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine EC 2.4.2.22 PhysiologicalDirection=right-to-left (RHEA:10802)
	RHEA:17973: diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine PhysiologicalDirection=right-to-left (RHEA:17975)
Cofactor	Mg(2+)
Pathway	Purine metabolism; GMP biosynthesis via salvage pathway; GMP from guanine: step 1/1.
	Purine metabolism; XMP biosynthesis via salvage pathway; XMP from xanthine: step 1/1.
Subunit	Homotetramer.

case not defined <Property:Membrane> or <Property:Membrane=1>

Subcellular location

Cell membrane; Peripheral membrane protein.

else case <Property:Membrane=2>

Subcellular location

Cell inner membrane; Peripheral membrane protein.

end case

Similarity

Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.

Keywords [?]

Cell membrane

case defined <Property:Membrane> and <Property:Membrane=2>

Cell inner membrane

end case

Glycosyltransferase
Magnesium
Metal-binding
Membrane
Purine salvage
Transferase

Gene Ontology [?]

GO:0000287; Molecular function: magnesium ion binding.
GO:0000310; Molecular function: xanthine phosphoribosyltransferase activity.
GO:0006166; Biological process: purine ribonucleoside salvage.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

PROSITE	PS00103; PUR_PYR_PR_TRANSFER; 1;
Pfam	PF00156; Pribosyltran; 1;

Features [?]

From: XGPT_ECOLI (P0A9M5)

Key From To Description Tag Condition FTGroup

BINDING 92 96 /ligand="GMP" /ligand_id="ChEBI:CHEBI:58115 D-[TS]-G-x-T

BINDING (Optional) 134 135 /ligand="GMP" /ligand_id="ChEBI:CHEBI:58115 W-[IV]

BINDING 37 38 /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017 R-G

BINDING 88 96 /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017

BINDING 89 89 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 D

BINDING (Optional) 69 69 /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017 [RKQ]

BINDING (Optional) 69 69 /ligand="GMP" /ligand_id="ChEBI:CHEBI:58115 [RKQ]

BINDING 92 92 /ligand="guanine" /ligand_id="ChEBI:CHEBI:16235 D

BINDING 92 92 /ligand="xanthine" /ligand_id="ChEBI:CHEBI:17712 D

BINDING (Optional) 135 135 /ligand="guanine" /ligand_id="ChEBI:CHEBI:16235 [IV]

BINDING (Optional) 135 135 /ligand="xanthine" /ligand_id="ChEBI:CHEBI:17712 [IV]

Additional information [?]

Size range	152-176 amino acids
Related rules	None
Fusion	None

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