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Annotation rule MF_01903
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General rule information [?]

Accession MF_01903
Dates 6-DEC-2005 (Created)
1-APR-2020 (Last updated, Version 27)
Name XGPRT
Scope
Bacteria; Proteobacteria
Templates P0A9M5 (XGPT_ECOLI); Q8ZC05 (XGPT_YERPE): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
XGPT
Protein name
RecName: Full=Xanthine-guanine phosphoribosyltransferase;
Short=XGPRT;
EC 2.4.2.-;
EC 2.4.2.22;
AltName: Full=Xanthine phosphoribosyltransferase;
Gene name
gpt

Comments [?]

Function Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-monophosphate) and XMP (xanthosine 5'-monophosphate), with the release of PPi. To a lesser extent, also acts on hypoxanthine.
Catalytic activity RHEA:25424: diphosphate + GMP = 5-phospho-alpha-D-ribose 1-diphosphate + guanine
PhysiologicalDirection=right-to-left (RHEA:25426)
RHEA:10800: diphosphate + XMP = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine
EC 2.4.2.22
PhysiologicalDirection=right-to-left (RHEA:10802)
RHEA:17973: diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine
PhysiologicalDirection=right-to-left (RHEA:17975)
Cofactor Mg(2+)
Pathway Purine metabolism; GMP biosynthesis via salvage pathway; GMP from guanine: step 1/1.
Purine metabolism; XMP biosynthesis via salvage pathway; XMP from xanthine: step 1/1.
Subunit Homotetramer.
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location Cell membrane; Peripheral membrane protein.
else case <Property:Membrane=2>
Subcellular location Cell inner membrane; Peripheral membrane protein.
end case
Similarity Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.

Keywords [?]

Cell membrane
case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Glycosyltransferase
Magnesium
Metal-binding
Membrane
Purine salvage
Transferase

Gene Ontology [?]

GO:0000287; Molecular function: magnesium ion binding.
GO:0000310; Molecular function: xanthine phosphoribosyltransferase activity.
GO:0006166; Biological process: purine ribonucleoside salvage.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

PROSITE PS00103; PUR_PYR_PR_TRANSFER; 1;
Pfam PF00156; Pribosyltran; 1;

Features [?]

From: XGPT_ECOLI (P0A9M5)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     92     96       GMP     D-[TS]-G-x-T  
NP_BIND (Optional)     134     135       GMP     W-[IV]  
REGION     37     38       5-phospho-alpha-D-ribose 1-diphosphate binding     R-G  
REGION     88     96       5-phospho-alpha-D-ribose 1-diphosphate binding        
METAL     89     89       Magnesium     D  
BINDING (Optional)     69     69       5-phospho-alpha-D-ribose 1-diphosphate     [RKQ]  
BINDING (Optional)     69     69       GMP     [RKQ]  
BINDING     92     92       Xanthine or guanine     D  
BINDING (Optional)     135     135       Xanthine or guanine; via amide nitrogen and carbonyl oxygen     [IV]  

Additional information [?]

Size range 152-176 amino acids
Related rules None
Fusion None


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