HAMAP rule MF_01903
General rule information
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Accession | MF_01903 |
Dates | 6-DEC-2005 (Created) 26-JAN-2023 (Last updated, Version 32) |
Name | XGPRT |
Scope | Bacteria; Pseudomonadota |
Templates | P0A9M5 (XGPT_ECOLI); Q8ZC05 (XGPT_YERPE): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-monophosphate) and XMP (xanthosine 5'-monophosphate), with the release of PPi. To a lesser extent, also acts on hypoxanthine. |
Catalytic activity | RHEA:25424: diphosphate + GMP = 5-phospho-alpha-D-ribose 1-diphosphate + guanine
PhysiologicalDirection=right-to-left (RHEA:25426) |
RHEA:10800: diphosphate + XMP = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine
EC 2.4.2.22 PhysiologicalDirection=right-to-left (RHEA:10802) |
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RHEA:17973: diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine
PhysiologicalDirection=right-to-left (RHEA:17975) |
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Cofactor | Mg(2+) |
Pathway | Purine metabolism; GMP biosynthesis via salvage pathway; GMP from guanine: step 1/1. |
Purine metabolism; XMP biosynthesis via salvage pathway; XMP from xanthine: step 1/1. | |
Subunit | Homotetramer. |
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location | Cell membrane; Peripheral membrane protein. |
else case <Property:Membrane=2>
Subcellular location | Cell inner membrane; Peripheral membrane protein. |
end case
Similarity | Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. |
Keywords
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case defined <Property:Membrane> and <Property:Membrane=2>
end case
Gene Ontology
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GO:0000287; Molecular function: magnesium ion binding.
GO:0000310; Molecular function: xanthine phosphoribosyltransferase activity.
GO:0006166; Biological process: purine ribonucleoside salvage.
GO:0005886; Cellular component: plasma membrane.
GO:0000310; Molecular function: xanthine phosphoribosyltransferase activity.
GO:0006166; Biological process: purine ribonucleoside salvage.
GO:0005886; Cellular component: plasma membrane.
Cross-references
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Features
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From: XGPT_ECOLI (P0A9M5) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 92 | 96 | /ligand="GMP" /ligand_id="ChEBI:CHEBI:58115 | D-[TS]-G-x-T | ||||||||
BINDING (Optional) | 134 | 135 | /ligand="GMP" /ligand_id="ChEBI:CHEBI:58115 | W-[IV] | ||||||||
BINDING | 37 | 38 | /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017 | R-G | ||||||||
BINDING | 88 | 96 | /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017 | |||||||||
BINDING | 89 | 89 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 | D | ||||||||
BINDING (Optional) | 69 | 69 | /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017 | [RKQ] | ||||||||
BINDING (Optional) | 69 | 69 | /ligand="GMP" /ligand_id="ChEBI:CHEBI:58115 | [RKQ] | ||||||||
BINDING | 92 | 92 | /ligand="guanine" /ligand_id="ChEBI:CHEBI:16235 | D | ||||||||
BINDING | 92 | 92 | /ligand="xanthine" /ligand_id="ChEBI:CHEBI:17712 | D | ||||||||
BINDING (Optional) | 135 | 135 | /ligand="guanine" /ligand_id="ChEBI:CHEBI:16235 | [IV] | ||||||||
BINDING (Optional) | 135 | 135 | /ligand="xanthine" /ligand_id="ChEBI:CHEBI:17712 | [IV] |
Additional information
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Size range | 152-176 amino acids |
Related rules | None |
Fusion | None |