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Annotation rule MF_01903 |
General rule information
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Accession |
MF_01903 |
Dates |
6-DEC-2005 (Created) 1-APR-2020 (Last updated, Version 27) |
Scope |
Bacteria; Proteobacteria |
Propagated annotation
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Identifier, protein and gene names
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Protein name |
RecName:
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Full=Xanthine-guanine phosphoribosyltransferase;
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Short=XGPRT;
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EC 2.4.2.-;
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EC 2.4.2.22;
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AltName:
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Full=Xanthine phosphoribosyltransferase;
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Function |
Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-monophosphate) and XMP (xanthosine 5'-monophosphate), with the release of PPi. To a lesser extent, also acts on hypoxanthine. |
Catalytic activity |
RHEA:25424: diphosphate + GMP = 5-phospho-alpha-D-ribose 1-diphosphate + guanine
PhysiologicalDirection=right-to-left
(RHEA:25426)
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RHEA:10800: diphosphate + XMP = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine
EC 2.4.2.22
PhysiologicalDirection=right-to-left
(RHEA:10802)
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RHEA:17973: diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine
PhysiologicalDirection=right-to-left
(RHEA:17975)
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Cofactor |
Mg(2+) |
Pathway |
Purine metabolism; GMP biosynthesis via salvage pathway; GMP from guanine: step 1/1. |
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Purine metabolism; XMP biosynthesis via salvage pathway; XMP from xanthine: step 1/1. |
Subunit |
Homotetramer. |
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location |
Cell membrane; Peripheral membrane protein. |
else case <Property:Membrane=2>
Subcellular location |
Cell inner membrane; Peripheral membrane protein. |
end case
Similarity |
Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. |
case defined <Property:Membrane> and <Property:Membrane=2>
end case
GO:0000287; Molecular function: magnesium ion binding.
GO:0000310; Molecular function: xanthine phosphoribosyltransferase activity.
GO:0006166; Biological process: purine ribonucleoside salvage.
GO:0005886; Cellular component: plasma membrane.
PROSITE |
PS00103; PUR_PYR_PR_TRANSFER; 1; |
Pfam |
PF00156; Pribosyltran; 1; |
From: XGPT_ECOLI (P0A9M5) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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NP_BIND
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92
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96
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GMP
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D-[TS]-G-x-T
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NP_BIND (Optional)
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134
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135
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GMP
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W-[IV]
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REGION
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37
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38
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5-phospho-alpha-D-ribose 1-diphosphate binding
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R-G
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REGION
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88
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96
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5-phospho-alpha-D-ribose 1-diphosphate binding
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METAL
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89
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89
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Magnesium
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D
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BINDING (Optional)
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69
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69
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5-phospho-alpha-D-ribose 1-diphosphate
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[RKQ]
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BINDING (Optional)
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69
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69
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GMP
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[RKQ]
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BINDING
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92
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92
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Xanthine or guanine
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D
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BINDING (Optional)
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135
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135
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Xanthine or guanine; via amide nitrogen and carbonyl oxygen
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[IV]
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Additional information
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Size range |
152-176 amino acids |
Related rules |
None |
Fusion |
None |