HAMAP rule MF_01903
General rule information
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Accession | MF_01903 |
Dates | 6-DEC-2005 (Created)
7-MAY-2024 (Last updated, Version 33) |
Name | XGPRT |
Scope(s) |
Bacteria Pseudomonadota |
Template(s) | P0A9M5 (XGPT_ECOLI); Q8ZC05 (XGPT_YERPE); [ Recover all ] |
Triggered by |
HAMAP; MF_01903 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | XGPT |
Protein name | RecName: Full=Xanthine-guanine phosphoribosyltransferase; Short=XGPRT; EC=2.4.2.-; EC=2.4.2.22; AltName: Full=Xanthine phosphoribosyltransferase; |
Gene name | Name=gpt; |
Comments
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FUNCTION | Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1- diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'- monophosphate) and XMP (xanthosine 5'-monophosphate), with the release of PPi. To a lesser extent, also acts on hypoxanthine. |
CATALYTIC ACTIVITY | Reaction=diphosphate + GMP = 5-phospho-alpha-D-ribose 1-diphosphate + guanine; Xref=Rhea:RHEA:25424, ChEBI:CHEBI:16235, ChEBI:CHEBI:33019, ChEBI:CHEBI:58017, ChEBI:CHEBI:58115; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:25426; |
CATALYTIC ACTIVITY | Reaction=diphosphate + XMP = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine; Xref=Rhea:RHEA:10800, ChEBI:CHEBI:17712, ChEBI:CHEBI:33019, ChEBI:CHEBI:57464, ChEBI:CHEBI:58017; EC=2.4.2.22; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:10802; |
CATALYTIC ACTIVITY | Reaction=diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine; Xref=Rhea:RHEA:17973, ChEBI:CHEBI:17368, ChEBI:CHEBI:33019, ChEBI:CHEBI:58017, ChEBI:CHEBI:58053; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:17975; |
COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
PATHWAY | Purine metabolism; GMP biosynthesis via salvage pathway; GMP from guanine: step 1/1. |
PATHWAY | Purine metabolism; XMP biosynthesis via salvage pathway; XMP from xanthine: step 1/1. |
SUBUNIT | Homotetramer. |
case not defined <Property:Membrane> or <Property:Membrane=1> | |
SUBCELLULAR LOCATION | Cell membrane; Peripheral membrane protein. |
else case <Property:Membrane=2> | |
SUBCELLULAR LOCATION | Cell inner membrane; Peripheral membrane protein. |
end case | |
SIMILARITY | Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. |
Keywords
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Cell membrane | |
case defined <Property:Membrane> and <Property:Membrane=2> | |
Cell inner membrane | |
end case | |
Glycosyltransferase | |
Magnesium | |
Metal-binding | |
Membrane | |
Purine salvage | |
Transferase |
Gene Ontology
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GO:0000287; Molecular function:magnesium ion binding |
GO:0000310; Molecular function:xanthine phosphoribosyltransferase activity |
GO:0032263; Biological process:GMP salvage |
GO:0032265; Biological process:XMP salvage |
GO:0005886; Cellular component:plasma membrane |
Cross-references
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Features
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From: XGPT_ECOLI (P0A9M5) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 92 | 96 | /ligand="GMP" /ligand_id="ChEBI:CHEBI:58115" |
D-[TS]-G-x-T | ||||||||
BINDING | 134 | 135 | /ligand="GMP" /ligand_id="ChEBI:CHEBI:58115" |
W-[IV] | ||||||||
BINDING | 37 | 38 | /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017" |
R-G | ||||||||
BINDING | 88 | 96 | /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017" |
|||||||||
BINDING | 89 | 89 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
D | ||||||||
BINDING | 69 | 69 | /ligand="5-phospho-alpha-D-ribose 1-diphosphate" /ligand_id="ChEBI:CHEBI:58017" |
[RKQ] | ||||||||
BINDING | 69 | 69 | /ligand="GMP" /ligand_id="ChEBI:CHEBI:58115" |
[RKQ] | ||||||||
BINDING | 92 | 92 | /ligand="guanine" /ligand_id="ChEBI:CHEBI:16235" |
D | ||||||||
BINDING | 92 | 92 | /ligand="xanthine" /ligand_id="ChEBI:CHEBI:17712" |
D | ||||||||
BINDING | 135 | 135 | /ligand="guanine" /ligand_id="ChEBI:CHEBI:16235" |
[IV] | ||||||||
BINDING | 135 | 135 | /ligand="xanthine" /ligand_id="ChEBI:CHEBI:17712" |
[IV] |
Additional information
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Size range | 152-176 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |