HAMAP rule MF_01906

General rule information [?]

Accession	MF_01906
Dates	28-NOV-2007 (Created) 19-NOV-2019 (Last updated, Version 13)
Name	3HBOH
Scope(s)	Bacteria Betaproteobacteria Alteromonadaceae
Template(s)	O05690 (HBOH1_RALPI); Q9X6X9 (HBOH2_RALPI); Q0K9H3 (HBOH_CUPNH); [ Recover all ]
Triggered by	HAMAP; MF_01906 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	HBOH
case <Feature:Signal==1>
Protein name	RecName: Full=D-(-)-3-hydroxybutyrate oligomer hydrolase; Short=3HB-oligomer hydrolase; Short=3HBOH; EC=3.1.1.22; Flags: Precursor;
else
Protein name	RecName: Full=D-(-)-3-hydroxybutyrate oligomer hydrolase; Short=3HB-oligomer hydrolase; Short=3HBOH; EC=3.1.1.22;
end case

Comments [?]

FUNCTION	Participates in the degradation of poly-3-hydroxybutyrate (PHB). It works downstream of poly(3-hydroxybutyrate) depolymerase, hydrolyzing D(-)-3-hydroxybutyrate oligomers of various length (3HB- oligomers) into 3HB-monomers.
CATALYTIC ACTIVITY	Reaction=(3R)-hydroxybutanoate dimer + H2O = 2 (R)-3-hydroxybutanoate + H(+); Xref=Rhea:RHEA:10172, ChEBI:CHEBI:10979, ChEBI:CHEBI:10983, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378; EC=3.1.1.22;
PATHWAY	Lipid metabolism; butanoate metabolism.
case <Feature:Signal==1>
SUBCELLULAR LOCATION	Secreted.
end case
SIMILARITY	Belongs to the D-(-)-3-hydroxybutyrate oligomer hydrolase family.

Keywords [?]

Gene Ontology [?]

GO:0047989; Molecular function:hydroxybutyrate-dimer hydrolase activity

GO:0019605; Biological process:butyrate metabolic process

Cross-references [?]

Pfam	PF10605; 3HBOH; 1;
PIRSF	PIRSF011409; HObutyrate_olig_hydrol; 1;
General	Signal; -; 0-1;

Features [?]

From: HBOH_CUPNH (Q0K9H3)

Key

From

Description

Tag

Condition

FTGroup

ACT_SITE

320

/note="Charge relay system"

Additional information [?]

Size range	695-750 amino acids
Related rules	None
Fusion	Nter: None Cter: None
Comments	HBOH_CUPNH is an atypical member since it has a predicted signal sequence but is intracellular.