HAMAP rule MF_01906
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_01906 |
| Accession | MF_01906 |
| Dates | 28-NOV-2007 (Created)
19-NOV-2019 (Last updated, Version 14) |
| Name | 3HBOH |
| Scope(s) |
Bacteria Betaproteobacteria Alteromonadaceae |
| Template(s) | O05690; Q9X6X9; Q0K9H3; [ Recover all ] |
| Triggered by |
HAMAP; MF_01906 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | HBOH |
| case <Feature:Signal==1> | |
| Protein name | RecName: Full=D-(-)-3-hydroxybutyrate oligomer hydrolase; Short=3HB-oligomer hydrolase; Short=3HBOH; EC=3.1.1.22; Flags: Precursor; |
| else | |
| Protein name | RecName: Full=D-(-)-3-hydroxybutyrate oligomer hydrolase; Short=3HB-oligomer hydrolase; Short=3HBOH; EC=3.1.1.22; |
| end case | |
Comments
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| FUNCTION | Participates in the degradation of poly-3-hydroxybutyrate (PHB). It works downstream of poly(3-hydroxybutyrate) depolymerase, hydrolyzing D(-)-3-hydroxybutyrate oligomers of various length (3HB- oligomers) into 3HB-monomers. |
| CATALYTIC ACTIVITY | Reaction=(3R)-hydroxybutanoate dimer + H2O = 2 (R)-3-hydroxybutanoate + H(+); Xref=Rhea:RHEA:10172, ChEBI:CHEBI:10979, ChEBI:CHEBI:10983, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378; EC=3.1.1.22; |
| PATHWAY | Lipid metabolism; butanoate metabolism. |
| case <Feature:Signal==1> | |
| SUBCELLULAR LOCATION | Secreted. |
| end case | |
| SIMILARITY | Belongs to the D-(-)-3-hydroxybutyrate oligomer hydrolase family. |
Keywords
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Gene Ontology
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| GO:0047989; Molecular function:hydroxybutyrate-dimer hydrolase activity |
| GO:0019605; Biological process:butyrate metabolic process |
Cross-references
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| Pfam | PF10605; 3HBOH; 1; |
| PIRSF | PIRSF011409; HObutyrate_olig_hydrol; 1; |
| General | Signal; -; 0-1; |
Features
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| From: HBOH_CUPNH (Q0K9H3) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 320 | 320 | /note="Charge relay system" | S | ||||||||
Additional information
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| Size range | 695-750 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | HBOH_CUPNH is an atypical member since it has a predicted signal sequence but is intracellular. |