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HAMAP rule MF_01918

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General rule information [?]

Accession MF_01918
Dates 16-APR-2014 (Created)
19-NOV-2019 (Last updated, Version 5)
Name Cardiolipin_synth_ClsC
Scope
Bacteria; Enterobacterales
Template P75919 (CLSC_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
CLSC
Protein name
RecName: Full=Cardiolipin synthase C;
Short=CL synthase;
EC 2.7.8.-;
Gene name
clsC

Comments [?]

Function Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) from phosphatidylglycerol (PG) and phosphatidylethanolamine (PE).
Catalytic activity RHEA:42972: 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = a cardiolipin + ethanolamine
Similarity Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsC sub-subfamily.

Keywords [?]

Lipid biosynthesis
Lipid metabolism
Phospholipid biosynthesis
Phospholipid metabolism
Transferase

Gene Ontology [?]

GO:0016780; Molecular function: phosphotransferase activity, for other substituted phosphate groups.
GO:0008654; Biological process: phospholipid biosynthetic process.

Cross-references [?]

PROSITE PS50035; PLD; 2; trigger=PRU00153;
Pfam PF13091; PLDc_2; 2;

Features [?]

From: CLSC_ECOLI (P75919)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     130     130             H  
ACT_SITE     132     132             K  
ACT_SITE     137     137             D  
ACT_SITE     369     369             H  
ACT_SITE     371     371             K  
ACT_SITE     376     376             D  

Additional information [?]

Size range 430-530 amino acids
Related rules None
Fusion None


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