HAMAP rule MF_01918
General rule information
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| Accession | MF_01918 |
| Dates | 16-APR-2014 (Created)
19-NOV-2019 (Last updated, Version 5) |
| Name | Cardiolipin_synth_ClsC |
| Scope(s) |
Bacteria Enterobacterales |
| Template(s) | P75919 (CLSC_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01918 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | CLSC |
| Protein name | RecName: Full=Cardiolipin synthase C; Short=CL synthase; EC=2.7.8.-; |
| Gene name | Name=clsC; |
Comments
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| FUNCTION | Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) from phosphatidylglycerol (PG) and phosphatidylethanolamine (PE). |
| CATALYTIC ACTIVITY | Reaction=1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2- diacyl-sn-glycero-3-phosphoethanolamine = a cardiolipin + ethanolamine; Xref=Rhea:RHEA:42972, ChEBI:CHEBI:57603, ChEBI:CHEBI:62237, ChEBI:CHEBI:64612, ChEBI:CHEBI:64716; |
| SIMILARITY | Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsC sub-subfamily. |
Keywords
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Gene Ontology
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| GO:0016780; Molecular function:phosphotransferase activity, for other substituted phosphate groups |
| GO:0008654; Biological process:phospholipid biosynthetic process |
Cross-references
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Features
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| From: CLSC_ECOLI (P75919) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 130 | 130 | H | |||||||||
| ACT_SITE | 132 | 132 | K | |||||||||
| ACT_SITE | 137 | 137 | D | |||||||||
| ACT_SITE | 369 | 369 | H | |||||||||
| ACT_SITE | 371 | 371 | K | |||||||||
| ACT_SITE | 376 | 376 | D | |||||||||
Additional information
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| Size range | 430-530 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |