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HAMAP rule MF_01918

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General rule information [?]

Accession MF_01918
Dates 16-APR-2014 (Created)
19-NOV-2019 (Last updated, Version 5)
Name Cardiolipin_synth_ClsC
Scope(s) Bacteria
Template(s) P75919 (CLSC_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01918 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier CLSC
Protein name RecName: Full=Cardiolipin synthase C;
                 Short=CL synthase;
Gene name Name=clsC;

Comments [?]

FUNCTIONCatalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) from phosphatidylglycerol (PG) and phosphatidylethanolamine (PE).
CATALYTIC ACTIVITY Reaction=1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2- diacyl-sn-glycero-3-phosphoethanolamine = a cardiolipin + ethanolamine; Xref=Rhea:RHEA:42972, ChEBI:CHEBI:57603, ChEBI:CHEBI:62237, ChEBI:CHEBI:64612, ChEBI:CHEBI:64716;
SIMILARITYBelongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsC sub-subfamily.

Keywords [?]

Gene Ontology [?]

GO:0016780; Molecular function:phosphotransferase activity, for other substituted phosphate groups
GO:0008654; Biological process:phospholipid biosynthetic process

Cross-references [?]

PROSITE PS50035; PLD; 2;
Pfam PF13091; PLDc_2; 2;

Features [?]

From: CLSC_ECOLI (P75919)
Key From To Description Tag Condition FTGroup
ACT_SITE 130 130 H
ACT_SITE 132 132 K
ACT_SITE 137 137 D
ACT_SITE 369 369 H
ACT_SITE 371 371 K
ACT_SITE 376 376 D

Additional information [?]

Size range 430-530 amino acids
Related rules None
Fusion Nter: None Cter: None

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