HAMAP rule MF_01923

General rule information [?]

Accession	MF_01923
Dates	23-MAY-2014 (Created) 1-JUN-2023 (Last updated, Version 9)

Name	Me_Asp_mutase_E

Scope

Bacteria

Archaea

Templates

P80077 (GLME_CLOCO); Q05509 (GLME_CLOTT): [Recover all]

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

GLME

Protein name

RecName:		Full=Glutamate mutase epsilon subunit;
		EC 5.4.99.1;
AltName:		Full=Glutamate mutase E chain;
AltName:		Full=Glutamate mutase large subunit;
AltName:		Full=Methylaspartate mutase;

Gene name

glmE

Comments [?]

Function	Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate).
Catalytic activity	RHEA:12857: (2S,3S)-3-methyl-L-aspartate = L-glutamate EC 5.4.99.1
Cofactor	adenosylcob(III)alamin
Pathway	Amino-acid degradation; L-glutamate degradation via mesaconate pathway; acetate and pyruvate from L-glutamate: step 1/4.
Subunit	Heterotetramer composed of 2 epsilon subunits (GlmE) and 2 sigma subunits (GlmS). GlmE exists as a homodimer and GlmS as a monomer.
Similarity	Belongs to the methylaspartate mutase GlmE subunit family.

Keywords [?]

Gene Ontology [?]

GO:0050097; Molecular function: methylaspartate mutase activity.
GO:0019670; Biological process: anaerobic glutamate catabolic process.

Cross-references [?]

Features [?]

From: GLME_CLOCO (P80077)

Key From To Description Tag Condition FTGroup

BINDING (Optional) 149 150 /ligand="L-glutamate" /ligand_id="ChEBI:CHEBI:29985 [RK]-H

BINDING (Optional) 66 66 /ligand="L-glutamate" /ligand_id="ChEBI:CHEBI:29985 R

BINDING (Optional) 68 68 /ligand="adenosylcob(III)alamin" /ligand_id="ChEBI:CHEBI:18408 G

BINDING (Optional) 100 100 /ligand="L-glutamate" /ligand_id="ChEBI:CHEBI:29985 R

BINDING (Optional) 123 123 /ligand="adenosylcob(III)alamin" /ligand_id="ChEBI:CHEBI:18408 N

BINDING (Optional) 171 171 /ligand="L-glutamate" /ligand_id="ChEBI:CHEBI:29985 [ED]

BINDING (Optional) 177 177 /ligand="L-glutamate" /ligand_id="ChEBI:CHEBI:29985 Y

BINDING (Optional) 180 180 /ligand="adenosylcob(III)alamin" /ligand_id="ChEBI:CHEBI:18408 P

BINDING (Optional) 181 181 /ligand="L-glutamate" /ligand_id="ChEBI:CHEBI:29985 Y

BINDING (Optional) 297 297 /ligand="adenosylcob(III)alamin" /ligand_id="ChEBI:CHEBI:18408 F

BINDING (Optional) 326 326 /ligand="adenosylcob(III)alamin" /ligand_id="ChEBI:CHEBI:18408 K

BINDING (Optional) 330 330 /ligand="adenosylcob(III)alamin" /ligand_id="ChEBI:CHEBI:18408 E

BINDING (Optional) 334 334 /ligand="adenosylcob(III)alamin" /ligand_id="ChEBI:CHEBI:18408 I

Additional information [?]