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HAMAP rule MF_01923

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General rule information [?]

Accession MF_01923
Dates 23-MAY-2014 (Created)
1-JUN-2023 (Last updated, Version 9)
Name Me_Asp_mutase_E
Templates P80077 (GLME_CLOCO); Q05509 (GLME_CLOTT): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Glutamate mutase epsilon subunit;
AltName: Full=Glutamate mutase E chain;
AltName: Full=Glutamate mutase large subunit;
AltName: Full=Methylaspartate mutase;
Gene name

Comments [?]

Function Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate).
Catalytic activity RHEA:12857: (2S,3S)-3-methyl-L-aspartate = L-glutamate
Cofactor adenosylcob(III)alamin
Pathway Amino-acid degradation; L-glutamate degradation via mesaconate pathway; acetate and pyruvate from L-glutamate: step 1/4.
Subunit Heterotetramer composed of 2 epsilon subunits (GlmE) and 2 sigma subunits (GlmS). GlmE exists as a homodimer and GlmS as a monomer.
Similarity Belongs to the methylaspartate mutase GlmE subunit family.

Keywords [?]

Gene Ontology [?]

GO:0050097; Molecular function: methylaspartate mutase activity.
GO:0019670; Biological process: anaerobic glutamate catabolic process.

Cross-references [?]

Pfam PF06368; Met_asp_mut_E; 1;
NCBIfam TIGR01503; MthylAspMut_E; 1;
PIRSF PIRSF001495; Met_asp_mut_epsi; 1;

Features [?]

From: GLME_CLOCO (P80077)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING (Optional)     149     150       /ligand="L-glutamate" /ligand_id="ChEBI:CHEBI:29985     [RK]-H  
BINDING (Optional)     66     66       /ligand="L-glutamate" /ligand_id="ChEBI:CHEBI:29985     R  
BINDING (Optional)     68     68       /ligand="adenosylcob(III)alamin" /ligand_id="ChEBI:CHEBI:18408     G  
BINDING (Optional)     100     100       /ligand="L-glutamate" /ligand_id="ChEBI:CHEBI:29985     R  
BINDING (Optional)     123     123       /ligand="adenosylcob(III)alamin" /ligand_id="ChEBI:CHEBI:18408     N  
BINDING (Optional)     171     171       /ligand="L-glutamate" /ligand_id="ChEBI:CHEBI:29985     [ED]  
BINDING (Optional)     177     177       /ligand="L-glutamate" /ligand_id="ChEBI:CHEBI:29985     Y  
BINDING (Optional)     180     180       /ligand="adenosylcob(III)alamin" /ligand_id="ChEBI:CHEBI:18408     P  
BINDING (Optional)     181     181       /ligand="L-glutamate" /ligand_id="ChEBI:CHEBI:29985     Y  
BINDING (Optional)     297     297       /ligand="adenosylcob(III)alamin" /ligand_id="ChEBI:CHEBI:18408     F  
BINDING (Optional)     326     326       /ligand="adenosylcob(III)alamin" /ligand_id="ChEBI:CHEBI:18408     K  
BINDING (Optional)     330     330       /ligand="adenosylcob(III)alamin" /ligand_id="ChEBI:CHEBI:18408     E  
BINDING (Optional)     334     334       /ligand="adenosylcob(III)alamin" /ligand_id="ChEBI:CHEBI:18408     I  

Additional information [?]

Size range 440-520 amino acids
Related rules None
Fusion None