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HAMAP rule MF_01923

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General rule information [?]

Accession MF_01923
Dates 23-MAY-2014 (Created)
1-JUN-2023 (Last updated, Version 9)
Name Me_Asp_mutase_E
Scope(s) Bacteria
Template(s) P80077 (GLME_CLOCO); Q05509 (GLME_CLOTT); [ Recover all ]
Triggered by HAMAP; MF_01923 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier GLME
Protein name RecName: Full=Glutamate mutase epsilon subunit;
AltName: Full=Glutamate mutase E chain;
AltName: Full=Glutamate mutase large subunit;
AltName: Full=Methylaspartate mutase;
Gene name Name=glmE;

Comments [?]

FUNCTIONCatalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate).
CATALYTIC ACTIVITY Reaction=(2S,3S)-3-methyl-L-aspartate = L-glutamate; Xref=Rhea:RHEA:12857, ChEBI:CHEBI:29985, ChEBI:CHEBI:58724; EC=;
COFACTOR Name=adenosylcob(III)alamin; Xref=ChEBI:CHEBI:18408;
PATHWAYAmino-acid degradation; L-glutamate degradation via mesaconate pathway; acetate and pyruvate from L-glutamate: step 1/4.
SUBUNITHeterotetramer composed of 2 epsilon subunits (GlmE) and 2 sigma subunits (GlmS). GlmE exists as a homodimer and GlmS as a monomer.
SIMILARITYBelongs to the methylaspartate mutase GlmE subunit family.

Keywords [?]

Gene Ontology [?]

GO:0050097; Molecular function:methylaspartate mutase activity
GO:0019670; Biological process:anaerobic glutamate catabolic process

Cross-references [?]

Pfam PF06368; Met_asp_mut_E; 1;
NCBIfam TIGR01503; MthylAspMut_E; 1;
PIRSF PIRSF001495; Met_asp_mut_epsi; 1;

Features [?]

From: GLME_CLOCO (P80077)
Key From To Description Tag Condition FTGroup
BINDING 149 150 /ligand="L-glutamate"
BINDING 66 66 /ligand="L-glutamate"
BINDING 68 68 /ligand="adenosylcob(III)alamin"
BINDING 100 100 /ligand="L-glutamate"
BINDING 123 123 /ligand="adenosylcob(III)alamin"
BINDING 171 171 /ligand="L-glutamate"
BINDING 177 177 /ligand="L-glutamate"
BINDING 180 180 /ligand="adenosylcob(III)alamin"
BINDING 181 181 /ligand="L-glutamate"
BINDING 297 297 /ligand="adenosylcob(III)alamin"
BINDING 326 326 /ligand="adenosylcob(III)alamin"
BINDING 330 330 /ligand="adenosylcob(III)alamin"
BINDING 334 334 /ligand="adenosylcob(III)alamin"

Additional information [?]

Size range 440-520 amino acids
Related rules None
Fusion Nter: None Cter: None

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