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Annotation rule MF_01925
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General rule information [?]

Accession MF_01925
Dates 16-JUN-2014 (Created)
19-NOV-2019 (Last updated, Version 4)
Name P5C_reductase
Scope
Bacteria
Archaea
Templates P0A9L8 (P5CR_ECOLI); P27771 (P5CR_TREPA); Q9HH99 (P5CR_METAC): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
P5CR
Protein name
RecName: Full=Pyrroline-5-carboxylate reductase;
Short=P5C reductase;
Short=P5CR;
EC 1.5.1.2;
AltName: Full=PCA reductase;
Gene name
proC

Comments [?]

Function Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
Catalytic activity RHEA:14109: L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH
EC 1.5.1.2
RHEA:14105: L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH
EC 1.5.1.2
Pathway Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.
Subcellular location Cytoplasm.
Similarity Belongs to the pyrroline-5-carboxylate reductase family.

Keywords [?]


Gene Ontology [?]

GO:0004735; Molecular function: pyrroline-5-carboxylate reductase activity.
GO:0006561; Biological process: proline biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

PROSITE PS00521; P5CR; 1;
Pfam PF03807; F420_oxidored; 1;
PF14748; P5CR_dimer; 1;
TIGRFAMs TIGR00112; proC; 1;
PIRSF PIRSF000193; Pyrrol-5-carb_rd; 1;

Additional information [?]

Size range 235-350 amino acids
Related rules None
Fusion None