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| Annotation rule MF_01925 |
General rule information
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| Accession | MF_01925 |
| Dates | 16-JUN-2014 (Created) 19-NOV-2019 (Last updated, Version 4) |
| Name | P5C_reductase |
| Scope | Bacteria
Archaea |
| Templates | P0A9L8 (P5CR_ECOLI); P27771 (P5CR_TREPA); Q9HH99 (P5CR_METAC): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. |
| Catalytic activity | RHEA:14109: L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH
EC 1.5.1.2 |
| RHEA:14105: L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH
EC 1.5.1.2 |
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| Pathway | Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1. |
| Subcellular location | Cytoplasm. |
| Similarity | Belongs to the pyrroline-5-carboxylate reductase family. |
Keywords
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Gene Ontology
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GO:0004735; Molecular function: pyrroline-5-carboxylate reductase activity.
GO:0006561; Biological process: proline biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
GO:0006561; Biological process: proline biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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| PROSITE | PS00521; P5CR; 1; |
| Pfam | PF03807; F420_oxidored; 1; |
| PF14748; P5CR_dimer; 1; | |
| TIGRFAMs | TIGR00112; proC; 1; |
| PIRSF | PIRSF000193; Pyrrol-5-carb_rd; 1; |
Additional information
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| Size range | 235-350 amino acids |
| Related rules | None |
| Fusion | None |