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HAMAP rule MF_01925

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General rule information [?]

Accession MF_01925
Dates 16-JUN-2014 (Created)
1-JUN-2023 (Last updated, Version 5)
Name P5C_reductase
Scope(s) Bacteria
Template(s) P0A9L8 (P5CR_ECOLI); P27771 (P5CR_TREPA); Q9HH99 (P5CR_METAC); [ Recover all ]
Triggered by HAMAP; MF_01925 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier P5CR
Protein name RecName: Full=Pyrroline-5-carboxylate reductase;
                 Short=P5C reductase;
AltName: Full=PCA reductase;
Gene name Name=proC;

Comments [?]

FUNCTIONCatalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
CATALYTIC ACTIVITY Reaction=L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH; Xref=Rhea:RHEA:14109, ChEBI:CHEBI:15378, ChEBI:CHEBI:15893, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:60039; EC=;
CATALYTIC ACTIVITY Reaction=L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH; Xref=Rhea:RHEA:14105, ChEBI:CHEBI:15378, ChEBI:CHEBI:15893, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:60039; EC=;
PATHWAYAmino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.
SIMILARITYBelongs to the pyrroline-5-carboxylate reductase family.

Keywords [?]

Gene Ontology [?]

GO:0004735; Molecular function:pyrroline-5-carboxylate reductase activity
GO:0006561; Biological process:proline biosynthetic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

PROSITE PS00521; P5CR; 1;
Pfam PF03807; F420_oxidored; 1;
Pfam PF14748; P5CR_dimer; 1;
NCBIfam TIGR00112; proC; 1;
PIRSF PIRSF000193; Pyrrol-5-carb_rd; 1;

Features [?]

Additional information [?]

Size range 235-350 amino acids
Related rules None
Fusion Nter: None Cter: None

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