HAMAP rule MF_01925

General rule information [?]

Accession	MF_01925
Dates	16-JUN-2014 (Created) 1-JUN-2023 (Last updated, Version 5)

Name	P5C_reductase

Scope

Bacteria

Archaea

Templates

P0A9L8 (P5CR_ECOLI); P27771 (P5CR_TREPA); Q9HH99 (P5CR_METAC): [Recover all]

Triggered by

HAMAP; MF_01925 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

P5CR

Protein name

RecName:		Full=Pyrroline-5-carboxylate reductase;
		Short=P5C reductase;
		Short=P5CR;
		EC 1.5.1.2;
AltName:		Full=PCA reductase;

Gene name

proC

Comments [?]

Function	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
Catalytic activity	RHEA:14109: L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH EC 1.5.1.2
	RHEA:14105: L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH EC 1.5.1.2
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.
Subcellular location	Cytoplasm.
Similarity	Belongs to the pyrroline-5-carboxylate reductase family.

Keywords [?]

Amino-acid biosynthesis
Cytoplasm
NADP
Oxidoreductase
Proline biosynthesis

Gene Ontology [?]

GO:0004735; Molecular function: pyrroline-5-carboxylate reductase activity.
GO:0006561; Biological process: proline biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

PROSITE	PS00521; P5CR; 1;
Pfam	PF03807; F420_oxidored; 1;
	PF14748; P5CR_dimer; 1;
NCBIfam	TIGR00112; proC; 1;
PIRSF	PIRSF000193; Pyrrol-5-carb_rd; 1;

Additional information [?]

Size range	235-350 amino acids
Related rules	None
Fusion	None

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