HAMAP rule MF_01925

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_01925
Accession	MF_01925
Dates	16-JUN-2014 (Created) 10-OCT-2024 (Last updated, Version 8)
Name	P5C_reductase
Scope(s)	Bacteria Archaea
Template(s)	P0A9L8 (P5CR_ECOLI); P27771 (P5CR_TREPA); Q9HH99 (P5CR_METAC); [ Recover all ]
Triggered by	HAMAP; MF_01925 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	P5CR
Protein name	RecName: Full=Pyrroline-5-carboxylate reductase; Short=P5C reductase; Short=P5CR; EC=1.5.1.2; AltName: Full=PCA reductase;
Gene name	Name=proC;

Comments [?]

FUNCTION	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
CATALYTIC ACTIVITY	Reaction=L-proline + NADP(+) = (S)-1-pyrroline-5-carboxylate + NADPH + 2 H(+); Xref=Rhea:RHEA:14109, ChEBI:CHEBI:15378, ChEBI:CHEBI:17388, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:60039; EC=1.5.1.2;
CATALYTIC ACTIVITY	Reaction=L-proline + NAD(+) = (S)-1-pyrroline-5-carboxylate + NADH + 2 H(+); Xref=Rhea:RHEA:14105, ChEBI:CHEBI:15378, ChEBI:CHEBI:17388, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:60039; EC=1.5.1.2;
PATHWAY	Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.
SUBCELLULAR LOCATION	Cytoplasm.
SIMILARITY	Belongs to the pyrroline-5-carboxylate reductase family.

Keywords [?]

Gene Ontology [?]

GO:0004735; Molecular function:pyrroline-5-carboxylate reductase activity

GO:0055129; Biological process:L-proline biosynthetic process

GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Features [?]

Additional information [?]