HAMAP rule MF_01935
General rule information
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| Accession | MF_01935 |
| Dates | 15-OCT-2014 (Created)
1-JUN-2023 (Last updated, Version 7) |
| Name | MenF |
| Scope(s) |
Bacteria |
| Template(s) | P38051 (MENF_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01935 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | MENF |
| Protein name | RecName: Full=Isochorismate synthase MenF; EC=5.4.4.2; AltName: Full=Isochorismate mutase; |
| Gene name | Name=menF; |
Comments
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| FUNCTION | Catalyzes the conversion of chorismate to isochorismate. |
| CATALYTIC ACTIVITY | Reaction=chorismate = isochorismate; Xref=Rhea:RHEA:18985, ChEBI:CHEBI:29748, ChEBI:CHEBI:29780; EC=5.4.4.2; |
| case <FTGroup:1> | |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
| end case | |
| PATHWAY | Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 1/7. |
| PATHWAY | Quinol/quinone metabolism; menaquinone biosynthesis. |
| SIMILARITY | Belongs to the isochorismate synthase family. |
Keywords
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| Isomerase | |
| Menaquinone biosynthesis | |
| case <FTGroup:1> | |
| Magnesium | |
| Metal-binding | |
| end case | |
Gene Ontology
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| GO:0008909; Molecular function:isochorismate synthase activity | |
| case <FTGroup:1> | |
| GO:0000287; Molecular function:magnesium ion binding | |
| end case | |
| GO:0009234; Biological process:menaquinone biosynthetic process | |
Cross-references
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Features
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| From: MENF_ECOLI (P38051) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 190 | 190 | /note="Proton acceptor" | K | ||||||||
| ACT_SITE | 240 | 240 | /note="Proton donor" | E | ||||||||
| BINDING | 284 | 284 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
E | 1 | |||||||
| BINDING | 416 | 416 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
E | 1 | |||||||
Additional information
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| Size range | 385-470 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |