HAMAP rule MF_01939
General rule information
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Accession | MF_01939 |
Dates | 24-NOV-2014 (Created) 1-JUN-2023 (Last updated, Version 9) |
Name | PrpB |
Scope | Bacteria
Archaea |
Templates | P77541 (PRPB_ECOLI); Q56062 (PRPB_SALTY); Q937P0 (PRPB_CUPNE): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Involved in the catabolism of short chain fatty acids (SCFA) via the 2-methylcitrate cycle (propionate degradation route). Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate via an alpha-carboxy-carbanion intermediate. |
Catalytic activity | RHEA:16809: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate
EC 4.1.3.30 |
Cofactor | Mg(2+) |
Pathway | Organic acid metabolism; propanoate degradation. |
Subunit | Homotetramer; dimer of dimers. |
Similarity | Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. |
Keywords
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Gene Ontology
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GO:0000287; Molecular function: magnesium ion binding.
GO:0046421; Molecular function: methylisocitrate lyase activity.
GO:0019629; Biological process: propionate catabolic process, 2-methylcitrate cycle.
GO:0046421; Molecular function: methylisocitrate lyase activity.
GO:0019629; Biological process: propionate catabolic process, 2-methylcitrate cycle.
Cross-references
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Features
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From: PRPB_ECOLI (P77541) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 45 | 47 | /ligand="substrate | S-x-[GA] | ||||||||
BINDING | 123 | 124 | /ligand="substrate | C-G | ||||||||
BINDING | 210 | 212 | /ligand="substrate | N-x-T | ||||||||
BINDING | 85 | 85 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 | D | ||||||||
BINDING | 87 | 87 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 | D | ||||||||
BINDING | 158 | 158 | /ligand="substrate | R | ||||||||
BINDING | 188 | 188 | /ligand="substrate | E | ||||||||
BINDING | 241 | 241 | /ligand="substrate | R | ||||||||
BINDING | 270 | 270 | /ligand="substrate | R |
Additional information
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Size range | 267-332 amino acids |
Related rules | None |
Fusion | None |