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Annotation rule MF_01942
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General rule information [?]

Accession MF_01942
Dates 11-DEC-2014 (Created)
19-NOV-2019 (Last updated, Version 4)
Name Lipid_A_LpxL_LpxP
Scope
Bacteria; Proteobacteria
Template P0ACV0 (LPXL_ECOLI)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
LPXL
Protein name
RecName: Full=Lipid A biosynthesis lauroyltransferase;
EC 2.3.1.241;
AltName: Full=Kdo(2)-lipid IV(A) lauroyltransferase;
Gene name
lpxL

Comments [?]

Function Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A).
Catalytic activity RHEA:28442: alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + dodecanoyl-[ACP] = dodecanoyl-(Kdo)2-lipid IVA + holo-[ACP]
EC 2.3.1.241
Pathway Glycolipid biosynthesis; KDO(2)-lipid A biosynthesis; KDO(2)-lipid A from CMP-3-deoxy-D-manno-octulosonate and lipid IV(A): step 3/4.
Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis.
Subcellular location Cell inner membrane; Single-pass membrane protein.
Similarity Belongs to the LpxL/LpxM/LpxP family.

Keywords [?]


Gene Ontology [?]

GO:0008913; Molecular function: lauroyltransferase activity.
GO:0036104; Biological process: Kdo2-lipid A biosynthetic process.
GO:0005887; Cellular component: integral component of plasma membrane.

Cross-references [?]

Pfam PF03279; Lip_A_acyltrans; 1;
TIGRFAMs TIGR02207; lipid_A_htrB; 1;
PIRSF PIRSF026649; MsbB; 1;

Computed features [?]

General Transmembrane; -; 1; trigger=yes;

Features [?]

From: LPXL_ECOLI (P0ACV0)
Key     From     To       Description   Tag   Condition   FTGroup
MOTIF     132     137       HXXXXD motif     H-x-x-x-x-[DE]  

Additional information [?]

Size range 260-360 amino acids
Related rules MF_01943 (LPXP supersedes the current rule)
Fusion None
Comments The associated profile (MF_01942) matches LpxL and LpxP, but the annotation rule is specific for LpxL. See MF_01943 for LpxP annotation.