HAMAP rule MF_01942
General rule information
[?]
| Accession | MF_01942 |
| Dates | 11-DEC-2014 (Created)
1-JUN-2023 (Last updated, Version 8) |
| Name | Lipid_A_LpxL_LpxP |
| Scope(s) |
Bacteria Pseudomonadota |
| Template(s) | P0ACV0 (LPXL_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01942 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier | LPXL |
| case <OC:Escherichia> | |
| Protein name | RecName: Full=Lipid A biosynthesis lauroyltransferase; EC=2.3.1.241; AltName: Full=Kdo(2)-lipid IV(A) lauroyltransferase; |
| else | |
| Protein name | RecName: Full=Lipid A biosynthesis acyltransferase; EC=2.3.1.241; AltName: Full=Kdo(2)-lipid IV(A) acyltransferase; |
| end case | |
| Gene name | Name=lpxL; |
Comments
[?]
| case <OC:Escherichia> | |
| FUNCTION | Catalyzes the transfer of laurate from lauroyl-[acyl-carrier- protein] (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A). |
| CATALYTIC ACTIVITY | Reaction=alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + dodecanoyl-[ACP] = alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(dodecanoyl)- lipid IVA (E. coli) + holo-[ACP]; Xref=Rhea:RHEA:28442, Rhea:RHEA- COMP:9644, Rhea:RHEA-COMP:9685, ChEBI:CHEBI:60365, ChEBI:CHEBI:61524, ChEBI:CHEBI:64479, ChEBI:CHEBI:65264; EC=2.3.1.241; |
| else | |
| FUNCTION | Catalyzes the transfer of an acyl chain from an acyl-[acyl- carrier-protein] (ACP) to a Kdo(2)-lipid IV(A) to form a Kdo(2)-(acyl)- lipid IV(A). |
| CATALYTIC ACTIVITY | Reaction=a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)- lipid IVA = an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)-lipid IVA + holo-[ACP]; Xref=Rhea:RHEA:69396, Rhea:RHEA-COMP:9685, Rhea:RHEA- COMP:14125, ChEBI:CHEBI:64479, ChEBI:CHEBI:138651, ChEBI:CHEBI:176429, ChEBI:CHEBI:176430; EC=2.3.1.241; |
| end case | |
| PATHWAY | Glycolipid biosynthesis; KDO(2)-lipid A biosynthesis; KDO(2)- lipid A from CMP-3-deoxy-D-manno-octulosonate and lipid IV(A): step 3/4. |
| PATHWAY | Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. |
| SUBCELLULAR LOCATION | Cell inner membrane; Single-pass membrane protein. |
| SIMILARITY | Belongs to the LpxL/LpxM/LpxP family. |
Keywords
[?]
| Acyltransferase |
| Cell inner membrane |
| Cell membrane |
| Lipopolysaccharide biosynthesis |
| Membrane |
| Transferase |
| Transmembrane |
| Transmembrane helix |
Gene Ontology
[?]
| case <OCellular component:Escherichia> | |
| GO:0008913; Molecular function:lauroyltransferase activity | |
| else; https://www.ebi.ac.uk/QuickGO/term/else | |
| GO:0016746; Molecular function:acyltransferase activity | |
| end case | |
| GO:0036104; Biological process:Kdo2-lipid A biosynthetic process | |
| GO:0005886; Cellular component:plasma membrane | |
Cross-references
[?]
| Pfam | PF03279; Lip_A_acyltrans; 1; |
| NCBIfam | TIGR02207; lipid_A_htrB; 1; |
| PIRSF | PIRSF026649; MsbB; 1; |
| General | Transmembrane; -; 1; |
Features
[?]
| From: LPXL_ECOLI (P0ACV0) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| MOTIF | 132 | 137 | /note="HXXXXD motif" | H-x-x-x-x-[DE] | ||||||||
Additional information
[?]
| Size range | 260-360 amino acids |
| Related rules |
MF_01943 |
| Fusion | Nter: None Cter: None |
| Comments | The associated profile (MF_01942) matches LpxL and LpxP, but the annotation rule is specific for LpxL. See MF_01943 for LpxP annotation. |