HAMAP rule MF_01943
General rule information
[?]
| Accession | MF_01943 |
| Dates | 11-DEC-2014 (Created)
1-JUN-2023 (Last updated, Version 9) |
| Name | Lipid_A_LpxP |
| Scope(s) |
Bacteria Enterobacterales |
| Template(s) | P0ACV2 (LPXP_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01943 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier | LPXP |
| case <OC:Escherichia> | |
| Protein name | RecName: Full=Lipid A biosynthesis palmitoleoyltransferase; EC=2.3.1.242; AltName: Full=Kdo(2)-lipid IV(A) palmitoleoyltransferase; |
| else | |
| Protein name | RecName: Full=Lipid A biosynthesis acyltransferase; EC=2.3.1.242; AltName: Full=Kdo(2)-lipid IV(A) acyltransferase; |
| end case | |
| Gene name | Name=lpxP; |
Comments
[?]
| case <OC:Escherichia> | |
| FUNCTION | Catalyzes the transfer of palmitoleate from palmitoleoyl- [acyl-carrier-protein] (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (palmitoleoyl)-lipid IV(A). |
| CATALYTIC ACTIVITY | Reaction=(9Z)-hexadecenoyl-[ACP] + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)- lipid IVA (E. coli) = (9Z)-hexadecenoyl-(Kdo)2-lipid IVA (E. coli) + holo-[ACP]; Xref=Rhea:RHEA:44012, Rhea:RHEA-COMP:9685, Rhea:RHEA- COMP:10800, ChEBI:CHEBI:60365, ChEBI:CHEBI:61520, ChEBI:CHEBI:64479, ChEBI:CHEBI:83989; EC=2.3.1.242; |
| else | |
| FUNCTION | Catalyzes the transfer of an acyl chain from an acyl-[acyl- carrier-protein] (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(acyl)- lipid IV(A). {ECO:0000255|HAMAP-Rule:MF_01943}. |
| CATALYTIC ACTIVITY | Reaction=a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)- lipid IVA = an acyl-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + holo-[ACP]; Xref=Rhea:RHEA:74287, Rhea:RHEA-COMP:9685, Rhea:RHEA- COMP:14125, ChEBI:CHEBI:64479, ChEBI:CHEBI:138651, ChEBI:CHEBI:176429, ChEBI:CHEBI:193149; EC=2.3.1.242; |
| end case | |
| PATHWAY | Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. |
| SUBCELLULAR LOCATION | Cell inner membrane; Single-pass membrane protein. |
| SIMILARITY | Belongs to the LpxL/LpxM/LpxP family. LpxP subfamily. |
Keywords
[?]
| Acyltransferase |
| Cell inner membrane |
| Cell membrane |
| Lipopolysaccharide biosynthesis |
| Membrane |
| Transferase |
| Transmembrane |
| Transmembrane helix |
Gene Ontology
[?]
| case <OCellular component:Escherichia> | |
| GO:0008951; Molecular function:palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity | |
| else; https://www.ebi.ac.uk/QuickGO/term/else | |
| GO:0016746; Molecular function:acyltransferase activity | |
| end case | |
| GO:0036104; Biological process:Kdo2-lipid A biosynthetic process | |
| GO:0005886; Cellular component:plasma membrane | |
Cross-references
[?]
| Pfam | PF03279; Lip_A_acyltrans; 1; |
| NCBIfam | TIGR02207; lipid_A_htrB; 1; |
| PIRSF | PIRSF026649; MsbB; 1; |
| General | Transmembrane; -; 1; |
Features
[?]
| From: LPXP_ECOLI (P0ACV2) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| MOTIF | 132 | 137 | /note="HXXXXD motif" | H-x-x-x-x-[DE] | ||||||||
Additional information
[?]
| Size range | 302-340 amino acids |
| Related rules |
MF_01942 |
| Fusion | Nter: None Cter: None |