HAMAP logo

HAMAP rule MF_01943

Send feedback

General rule information [?]

Accession MF_01943
Dates 11-DEC-2014 (Created)
1-JUN-2023 (Last updated, Version 9)
Name Lipid_A_LpxP
Scope(s) Bacteria
Template(s) P0ACV2 (LPXP_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01943 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier LPXP
case <OC:Escherichia>
Protein name RecName: Full=Lipid A biosynthesis palmitoleoyltransferase;
AltName: Full=Kdo(2)-lipid IV(A) palmitoleoyltransferase;
Protein name RecName: Full=Lipid A biosynthesis acyltransferase;
AltName: Full=Kdo(2)-lipid IV(A) acyltransferase;
end case
Gene name Name=lpxP;

Comments [?]

case <OC:Escherichia>
FUNCTIONCatalyzes the transfer of palmitoleate from palmitoleoyl- [acyl-carrier-protein] (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (palmitoleoyl)-lipid IV(A).
CATALYTIC ACTIVITY Reaction=(9Z)-hexadecenoyl-[ACP] + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)- lipid IVA (E. coli) = (9Z)-hexadecenoyl-(Kdo)2-lipid IVA (E. coli) + holo-[ACP]; Xref=Rhea:RHEA:44012, Rhea:RHEA-COMP:9685, Rhea:RHEA- COMP:10800, ChEBI:CHEBI:60365, ChEBI:CHEBI:61520, ChEBI:CHEBI:64479, ChEBI:CHEBI:83989; EC=;
FUNCTIONCatalyzes the transfer of an acyl chain from an acyl-[acyl- carrier-protein] (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(acyl)- lipid IV(A). {ECO:0000255|HAMAP-Rule:MF_01943}.
CATALYTIC ACTIVITY Reaction=a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)- lipid IVA = an acyl-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + holo-[ACP]; Xref=Rhea:RHEA:74287, Rhea:RHEA-COMP:9685, Rhea:RHEA- COMP:14125, ChEBI:CHEBI:64479, ChEBI:CHEBI:138651, ChEBI:CHEBI:176429, ChEBI:CHEBI:193149; EC=;
end case
PATHWAYBacterial outer membrane biogenesis; lipopolysaccharide biosynthesis.
SUBCELLULAR LOCATIONCell inner membrane; Single-pass membrane protein.
SIMILARITYBelongs to the LpxL/LpxM/LpxP family. LpxP subfamily.

Keywords [?]

Gene Ontology [?]

case <OCellular component:Escherichia>
GO:0008951; Molecular function:palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity
else; https://www.ebi.ac.uk/QuickGO/term/else
GO:0016746; Molecular function:acyltransferase activity
end case
GO:0036104; Biological process:Kdo2-lipid A biosynthetic process
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam PF03279; Lip_A_acyltrans; 1;
NCBIfam TIGR02207; lipid_A_htrB; 1;
PIRSF PIRSF026649; MsbB; 1;
General Transmembrane; -; 1;

Features [?]

Key From To Description Tag Condition FTGroup
MOTIF 132 137 /note="HXXXXD motif" H-x-x-x-x-[DE]

Additional information [?]

Size range 302-340 amino acids
Related rules MF_01942
Fusion Nter: None Cter: None

View rule in raw text format (no links)