HAMAP rule MF_01947
General rule information
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Accession | MF_01947 |
Dates | 15-JAN-2015 (Created)
19-NOV-2019 (Last updated, Version 3) |
Name | Aminopropyltransf_BpsA |
Scope(s) |
Bacteria Archaea |
Template(s) | Q5JIZ3 (BPSA_THEKO); [ Recover all ] |
Triggered by |
HAMAP; MF_01947 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | BPSA |
Protein name | RecName: Full=N(4)-bis(aminopropyl)spermidine synthase; EC=2.5.1.128; AltName: Full=Branched-chain polyamine synthase A; |
Gene name | Name=bpsA; |
Comments
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FUNCTION | Involved in the biosynthesis of branched-chain polyamines, which support the growth of thermophiles under high-temperature conditions. Catalyzes the sequential condensation of spermidine with the aminopropyl groups of decarboxylated S-adenosylmethionines to produce N(4)-bis(aminopropyl)spermidine via N(4)-aminopropylspermidine. |
CATALYTIC ACTIVITY | Reaction=2 S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = 2 H(+) + N(4)-bis(aminopropyl)spermidine + 2 S-methyl-5'-thioadenosine; Xref=Rhea:RHEA:44132, ChEBI:CHEBI:15378, ChEBI:CHEBI:17509, ChEBI:CHEBI:57443, ChEBI:CHEBI:57834, ChEBI:CHEBI:82771; EC=2.5.1.128; |
PATHWAY | Amine and polyamine biosynthesis. |
SUBCELLULAR LOCATION | Cytoplasm. |
SIMILARITY | Belongs to the branched-chain polyamine synthase family. |
Keywords
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Gene Ontology
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GO:0016765; Molecular function:transferase activity, transferring alkyl or aryl (other than methyl) groups |
GO:0006596; Biological process:polyamine biosynthetic process |
GO:0005737; Cellular component:cytoplasm |
Cross-references
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Pfam | PF01861; DUF43; 1; |
PIRSF | PIRSF005895; UCP005895_mtase; 1; |
Features
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Additional information
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Size range | 320-375 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |