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HAMAP rule MF_01947

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General rule information [?]

Accession MF_01947
Dates 15-JAN-2015 (Created)
19-NOV-2019 (Last updated, Version 3)
Name Aminopropyltransf_BpsA
Scope(s) Bacteria
Template(s) Q5JIZ3 (BPSA_THEKO); [ Recover all ]
Triggered by HAMAP; MF_01947 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier BPSA
Protein name RecName: Full=N(4)-bis(aminopropyl)spermidine synthase;
AltName: Full=Branched-chain polyamine synthase A;
Gene name Name=bpsA;

Comments [?]

FUNCTIONInvolved in the biosynthesis of branched-chain polyamines, which support the growth of thermophiles under high-temperature conditions. Catalyzes the sequential condensation of spermidine with the aminopropyl groups of decarboxylated S-adenosylmethionines to produce N(4)-bis(aminopropyl)spermidine via N(4)-aminopropylspermidine.
CATALYTIC ACTIVITY Reaction=2 S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = 2 H(+) + N(4)-bis(aminopropyl)spermidine + 2 S-methyl-5'-thioadenosine; Xref=Rhea:RHEA:44132, ChEBI:CHEBI:15378, ChEBI:CHEBI:17509, ChEBI:CHEBI:57443, ChEBI:CHEBI:57834, ChEBI:CHEBI:82771; EC=;
PATHWAYAmine and polyamine biosynthesis.
SIMILARITYBelongs to the branched-chain polyamine synthase family.

Keywords [?]

Gene Ontology [?]

GO:0016765; Molecular function:transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0006596; Biological process:polyamine biosynthetic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF01861; DUF43; 1;
PIRSF PIRSF005895; UCP005895_mtase; 1;

Features [?]

Additional information [?]

Size range 320-375 amino acids
Related rules None
Fusion Nter: None Cter: None

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