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HAMAP rule MF_01955

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General rule information [?]

Accession MF_01955
Dates 10-APR-2006 (Created)
1-JUN-2023 (Last updated, Version 20)
Name Urease_beta_gamma
Scope(s) Bacteria
Template(s) P14916 (URE23_HELPY); [ Recover all ]
Triggered by HAMAP; MF_01955 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier URE23
case <OC:Campylobacterales>
Protein name RecName: Full=Urease subunit alpha;
AltName: Full=Urea amidohydrolase subunit alpha;
Gene name Name=ureA;
else case not <OC:Campylobacterales>
Protein name RecName: Full=Urease subunit gamma/beta;
AltName: Full=Urea amidohydrolase subunit gamma/beta;
Gene name Name=ureAB;
end case

Comments [?]

CATALYTIC ACTIVITY Reaction=2 H(+) + H2O + urea = CO2 + 2 NH4(+); Xref=Rhea:RHEA:20557, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16199, ChEBI:CHEBI:16526, ChEBI:CHEBI:28938; EC=;
PATHWAYNitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.
case <OC:Campylobacterales>
SUBUNITHeterohexamer of 3 UreA (alpha) and 3 UreB (beta) subunits.
else case not <OC:Campylobacterales>
SUBUNITHeterohexamer of 3 UreC (alpha) and 3 UreAB (gamma/beta) subunits.
end case
SIMILARITYIn the N-terminal section; belongs to the urease gamma subunit family.
SIMILARITYIn the C-terminal section; belongs to the urease beta subunit family.
case <OC:Campylobacterales>
CAUTIONThe orthologous protein is known as the gamma/beta subunit (UreAB) in most other bacteria.
end case

Keywords [?]

Gene Ontology [?]

GO:0009039; Molecular function:urease activity
GO:0019627; Biological process:urea metabolic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF00699; Urease_beta; 1;
Pfam PF00547; Urease_gamma; 1;
NCBIfam TIGR00192; Urease_beta; 1;
NCBIfam TIGR00193; Urease_gam; 1;

Features [?]

From: URE23_HELPY (P14916)
Key From To Description Tag Condition FTGroup
REGION Nter 102 /note="Urease gamma"
REGION 103 Cter /note="Urease beta"

Additional information [?]

Size range 219-238 amino acids
Related rules MF_00739
Fusion Nter: None Cter: None

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