HAMAP rule MF_01955
General rule information
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| Accession | MF_01955 |
| Dates | 10-APR-2006 (Created)
3-SEP-2024 (Last updated, Version 23) |
| Name | Urease_beta_gamma |
| Scope(s) |
Bacteria Kitasatosporales Deinococcales Campylobacterales Pseudomonadaceae Archaea Sulfolobales |
| Template(s) | P14916 (URE23_HELPY); [ Recover all ] |
| Triggered by |
HAMAP; MF_01955 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | URE23 |
| case <OC:Campylobacterales> | |
| Protein name | RecName: Full=Urease subunit alpha; EC=3.5.1.5; AltName: Full=Urea amidohydrolase subunit alpha; |
| Gene name | Name=ureA; |
| else case not <OC:Campylobacterales> | |
| Protein name | RecName: Full=Urease subunit gamma/beta; EC=3.5.1.5; AltName: Full=Urea amidohydrolase subunit gamma/beta; |
| Gene name | Name=ureAB; |
| end case | |
Comments
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| CATALYTIC ACTIVITY | Reaction=urea + 2 H2O + H(+) = hydrogencarbonate + 2 NH4(+); Xref=Rhea:RHEA:20557, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16199, ChEBI:CHEBI:17544, ChEBI:CHEBI:28938; EC=3.5.1.5; |
| PATHWAY | Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1. |
| case <OC:Campylobacterales> | |
| SUBUNIT | Heterohexamer of 3 UreA (alpha) and 3 UreB (beta) subunits. |
| else case not <OC:Campylobacterales> | |
| SUBUNIT | Heterohexamer of 3 UreC (alpha) and 3 UreAB (gamma/beta) subunits. |
| end case | |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | In the N-terminal section; belongs to the urease gamma subunit family. |
| SIMILARITY | In the C-terminal section; belongs to the urease beta subunit family. |
| case <OC:Campylobacterales> | |
| CAUTION | The orthologous protein is known as the gamma/beta subunit (UreAB) in most other bacteria. |
| end case | |
Keywords
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Gene Ontology
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| GO:0009039; Molecular function:urease activity |
| GO:0043419; Biological process:urea catabolic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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| Pfam | PF00699; Urease_beta; 1; |
| Pfam | PF00547; Urease_gamma; 1; |
| NCBIfam | TIGR00192; Urease_beta; 1; |
| NCBIfam | TIGR00193; Urease_gam; 1; |
Features
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| From: URE23_HELPY (P14916) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| REGION | Nter | 102 | /note="Urease gamma" | |||||||||
| REGION | 103 | Cter | /note="Urease beta" | |||||||||
Additional information
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| Size range | 219-238 amino acids |
| Related rules |
MF_00739 MF_01954 |
| Fusion | Nter: None Cter: None |