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HAMAP rule MF_01959

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General rule information [?]

Accession MF_01959
Dates 12-MAY-2006 (Created)
26-JAN-2023 (Last updated, Version 28)
Name CcmE
Scope(s) Bacteria
Template(s) P69490 (CCME_ECOLI); Q8EK44 (CCME_SHEON); [ Recover all ]
Triggered by HAMAP; MF_01959 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier CCME
Protein name RecName: Full=Cytochrome c-type biogenesis protein CcmE;
AltName: Full=Cytochrome c maturation protein E;
AltName: Full=Heme chaperone CcmE;
Gene name Name=ccmE; Synonyms=cycJ;

Comments [?]

FUNCTIONHeme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.
case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATIONCell membrane; Single-pass type II membrane protein.
else case <Property:Membrane=2>
SUBCELLULAR LOCATIONCell inner membrane; Single-pass type II membrane protein; Periplasmic side.
end case
SIMILARITYBelongs to the CcmE/CycJ family.

Keywords [?]

Gene Ontology [?]

GO:0017003; Biological process:protein-heme linkage
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam PF03100; CcmE; 1;

Features [?]

From: CCME_ECOLI (P69490)
Key From To Description Tag Condition FTGroup
TOPO_DOM Nter 8 /note="Cytoplasmic"
TRANSMEM 9 29 /note="Helical; Signal-anchor for type II membrane protein"
case not defined <Property:Membrane> or <Property:Membrane=1>
TOPO_DOM 30 Cter /note="Extracellular"
end case
case defined <Property:Membrane> and <Property:Membrane=2>
TOPO_DOM 30 Cter /note="Periplasmic"
end case
BINDING 134 134 /ligand="heme"
/note="axial binding residue"
BINDING 130 130 /ligand="heme"

Additional information [?]

Size range 128-181 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments In SALCH, the duplicated copy ccmE2 is fused to ccmA2, however, important parts of the proteins are missing and it is therefore probably not functional. May be a pseudogene.

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