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HAMAP rule MF_01959
General rule information
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| Accession | MF_01959 |
| Dates | 12-MAY-2006 (Created)
26-JAN-2023 (Last updated, Version 28) |
| Name | CcmE |
| Scope(s) |
Bacteria Deinococci Pseudomonadota |
| Template(s) | P69490 (CCME_ECOLI); Q8EK44 (CCME_SHEON); [ Recover all ] |
| Triggered by |
HAMAP; MF_01959 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | CCME |
| Protein name | RecName: Full=Cytochrome c-type biogenesis protein CcmE; AltName: Full=Cytochrome c maturation protein E; AltName: Full=Heme chaperone CcmE; |
| Gene name | Name=ccmE; Synonyms=cycJ; |
Comments
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| FUNCTION | Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH. |
| case not defined <Property:Membrane> or <Property:Membrane=1> | |
| SUBCELLULAR LOCATION | Cell membrane; Single-pass type II membrane protein. |
| else case <Property:Membrane=2> | |
| SUBCELLULAR LOCATION | Cell inner membrane; Single-pass type II membrane protein; Periplasmic side. |
| end case | |
| SIMILARITY | Belongs to the CcmE/CycJ family. |
Keywords
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| Cytochrome c-type biogenesis | |
| Heme | |
| Cell membrane | |
| case defined <Property:Membrane> and <Property:Membrane=2> | |
| Cell inner membrane | |
| end case | |
| Iron | |
| Membrane | |
| Metal-binding | |
| Transmembrane | |
| Signal-anchor | |
| Transmembrane helix | |
Gene Ontology
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| GO:0017003; Biological process:protein-heme linkage |
| GO:0005886; Cellular component:plasma membrane |
Cross-references
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| Pfam | PF03100; CcmE; 1; |
Features
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| From: CCME_ECOLI (P69490) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| TOPO_DOM | Nter | 8 | /note="Cytoplasmic" | |||||||||
| TRANSMEM | 9 | 29 | /note="Helical; Signal-anchor for type II membrane protein" | |||||||||
| case not defined <Property:Membrane> or <Property:Membrane=1> | ||||||||||||
| TOPO_DOM | 30 | Cter | /note="Extracellular" | |||||||||
| end case | ||||||||||||
| case defined <Property:Membrane> and <Property:Membrane=2> | ||||||||||||
| TOPO_DOM | 30 | Cter | /note="Periplasmic" | |||||||||
| end case | ||||||||||||
| BINDING | 134 | 134 | /ligand="heme" /ligand_id="ChEBI:CHEBI:30413" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue" |
Y | ||||||||
| BINDING | 130 | 130 | /ligand="heme" /ligand_id="ChEBI:CHEBI:30413" /note="covalent" |
H | ||||||||
Additional information
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| Size range | 128-181 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | In SALCH, the duplicated copy ccmE2 is fused to ccmA2, however, important parts of the proteins are missing and it is therefore probably not functional. May be a pseudogene. |