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Annotation rule MF_01959
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General rule information [?]

Accession MF_01959
Dates 12-MAY-2006 (Created)
19-JAN-2021 (Last updated, Version 25)
Name CcmE
Scope
Bacteria; Deinococci
Bacteria; Proteobacteria
Templates P69490 (); Q8EK44 (): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
CCME
Protein name
RecName: Full=Cytochrome c-type biogenesis protein CcmE;
AltName: Full=Cytochrome c maturation protein E;
AltName: Full=Heme chaperone CcmE;
Gene name
ccmE, cycJ

Comments [?]

Function Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location Cell membrane; Single-pass type II membrane protein.
else case <Property:Membrane=2>
Subcellular location Cell inner membrane; Single-pass type II membrane protein; Periplasmic side.
end case
Similarity Belongs to the CcmE/CycJ family.

Keywords [?]

Cytochrome c-type biogenesis
Heme
Cell membrane
case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Iron
Membrane
Metal-binding
Transmembrane
Signal-anchor
Transmembrane helix

Gene Ontology [?]

GO:0017003; Biological process: protein-heme linkage.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF03100; CcmE; 1;

Features [?]

From: CCME_ECOLI (P69490)
Key     From     To       Description   Tag   Condition   FTGroup
TOPO_DOM     Nter     8       Cytoplasmic        
TRANSMEM     9     29       Helical; Signal-anchor for type II membrane protein        
case not defined <Property:Membrane> or <Property:Membrane=1>
TOPO_DOM     30     Cter       Extracellular        
end case
case defined <Property:Membrane> and <Property:Membrane=2>
TOPO_DOM     30     Cter       Periplasmic        
end case
METAL     134     134       Iron (heme axial ligand)     Y  
BINDING     130     130       Heme; covalent, via pros nitrogen     H  

Additional information [?]

Size range 128-181 amino acids
Related rules None
Fusion None
Comments In SALCH, the duplicated copy ccmE2 is fused to ccmA2, however, important parts of the proteins are missing and it is therefore probably not functional. May be a pseudogene.


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