 |
|
| Annotation rule MF_01960 |
General rule information
[?]
| Accession | MF_01960 |
| Dates | 6-SEP-2006 (Created) 19-NOV-2019 (Last updated, Version 12) |
| Name | D_aminopeptidase |
| Scope | Bacteria; Alphaproteobacteria |
| Template | Q9ZBA9 (DAP_OCHAN) |
| Triggered by |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier |
|
| Protein name |
|
||||||||
| Gene name |
|
Comments
[?]
| Function | Hydrolyzes N-terminal residues in D-amino acid-containing peptides. |
| Catalytic activity | Reaction=Release of an N-terminal D-amino acid from a peptide, Xaa-|-Yaa-, in which Xaa is preferably D-Ala, D-Ser or D-Thr. D-amino acid amides and methyl esters also are hydrolyzed, as is glycine amide.; EC=3.4.11.19; |
| Activity regulation | Inhibited by beta-lactam compounds such as 6-aminopenicillic acid, 7-aminocephalosporanic acid, benzylpenicillin and ampicillin. Inhibited by p-chloromercuribenzoate. |
| Subunit | Homodimer. |
| Similarity | Belongs to the peptidase S12 family. |
Keywords
[?]
Gene Ontology
[?]
GO:0004177; Molecular function: aminopeptidase activity.
Cross-references
[?]
Features
[?]
| From: DAP_OCHAN (Q9ZBA9) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| REGION | 477 | 487 | Important for specificity | |||||||||
| ACT_SITE | 62 | 62 | Nucleophile | S | ||||||||
| ACT_SITE | 65 | 65 | Proton donor/acceptor | K | ||||||||
| BINDING | 481 | 481 | Substrate | D | ||||||||
Additional information
[?]
| Size range | 516-525 amino acids |
| Related rules | None |
| Fusion | None |