HAMAP rule MF_01960
General rule information
[?]
| Accession |
MF_01960 |
| Dates |
6-SEP-2006 (Created)
14-MAY-2022 (Last updated, Version 14) |
| Scope |
Bacteria; Alphaproteobacteria |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Function |
Hydrolyzes N-terminal residues in D-amino acid-containing peptides. |
| Catalytic activity |
Reaction=Release of an N-terminal D-amino acid from a peptide, Xaa-|-Yaa-, in which Xaa is preferably D-Ala, D-Ser or D-Thr. D-amino acid amides and methyl esters also are hydrolyzed, as is glycine amide.; EC=3.4.11.19; |
| Activity regulation |
Inhibited by beta-lactam compounds such as 6-aminopenicillic acid, 7-aminocephalosporanic acid, benzylpenicillin and ampicillin. Inhibited by p-chloromercuribenzoate. |
| Subunit |
Homodimer. |
| Similarity |
Belongs to the peptidase S12 family. |
GO:0004177; Molecular function: aminopeptidase activity.
| From: DAP_BRUAN (Q9ZBA9) |
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Key
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From
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To
|
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Description
|
|
Tag
|
|
Condition
|
|
FTGroup
|
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REGION
|
|
477
|
|
487
|
|
Important for specificity
|
|
|
|
|
|
|
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ACT_SITE
|
|
62
|
|
62
|
|
Nucleophile
|
|
|
|
S
|
|
|
|
ACT_SITE
|
|
65
|
|
65
|
|
Proton donor/acceptor
|
|
|
|
K
|
|
|
|
BINDING
|
|
481
|
|
481
|
|
/ligand="substrate
|
|
|
|
D
|
|
|
Additional information
[?]
| Size range |
516-525 amino acids |
| Related rules |
None |
| Fusion |
None |
