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HAMAP rule MF_01960

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General rule information [?]

Accession MF_01960
Dates 6-SEP-2006 (Created)
14-MAY-2022 (Last updated, Version 14)
Name D_aminopeptidase
Bacteria; Alphaproteobacteria
Template Q9ZBA9 (DAP_BRUAN)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=D-aminopeptidase;
Gene name

Comments [?]

Function Hydrolyzes N-terminal residues in D-amino acid-containing peptides.
Catalytic activity Reaction=Release of an N-terminal D-amino acid from a peptide, Xaa-|-Yaa-, in which Xaa is preferably D-Ala, D-Ser or D-Thr. D-amino acid amides and methyl esters also are hydrolyzed, as is glycine amide.; EC=;
Activity regulation Inhibited by beta-lactam compounds such as 6-aminopenicillic acid, 7-aminocephalosporanic acid, benzylpenicillin and ampicillin. Inhibited by p-chloromercuribenzoate.
Subunit Homodimer.
Similarity Belongs to the peptidase S12 family.

Keywords [?]

Gene Ontology [?]

GO:0004177; Molecular function: aminopeptidase activity.

Cross-references [?]

Pfam PF00144; Beta-lactamase; 1;
PF07930; DAP_B; 1;
PF07932; DAP_C; 1;

Features [?]

Key     From     To       Description   Tag   Condition   FTGroup
REGION     477     487       Important for specificity        
ACT_SITE     62     62       Nucleophile     S  
ACT_SITE     65     65       Proton donor/acceptor     K  
BINDING     481     481       /ligand="substrate     D  

Additional information [?]

Size range 516-525 amino acids
Related rules None
Fusion None