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HAMAP rule MF_01960

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General rule information [?]

Accession MF_01960
Dates 6-SEP-2006 (Created)
14-MAY-2022 (Last updated, Version 14)
Name D_aminopeptidase
Scope(s) Bacteria
Template(s) Q9ZBA9 (DAP_BRUAN); [ Recover all ]
Triggered by HAMAP; MF_01960 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier DAP
Protein name RecName: Full=D-aminopeptidase;
Gene name Name=dap;

Comments [?]

FUNCTIONHydrolyzes N-terminal residues in D-amino acid-containing peptides.
CATALYTIC ACTIVITY Reaction=Release of an N-terminal D-amino acid from a peptide, Xaa-|- Yaa-, in which Xaa is preferably D-Ala, D-Ser or D-Thr. D-amino acid amides and methyl esters also are hydrolyzed, as is glycine amide.; EC=;
ACTIVITY REGULATIONInhibited by beta-lactam compounds such as 6- aminopenicillic acid, 7-aminocephalosporanic acid, benzylpenicillin and ampicillin. Inhibited by p-chloromercuribenzoate.
SIMILARITYBelongs to the peptidase S12 family.

Keywords [?]

Gene Ontology [?]

GO:0004177; Molecular function:aminopeptidase activity

Cross-references [?]

Pfam PF00144; Beta-lactamase; 1;
Pfam PF07930; DAP_B; 1;
Pfam PF07932; DAP_C; 1;

Features [?]

Key From To Description Tag Condition FTGroup
REGION 477 487 /note="Important for specificity"
ACT_SITE 62 62 /note="Nucleophile" S
ACT_SITE 65 65 /note="Proton donor/acceptor" K
BINDING 481 481 /ligand="substrate" D

Additional information [?]

Size range 516-525 amino acids
Related rules None
Fusion Nter: None Cter: None

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