HAMAP rule MF_01962
General rule information
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| Accession | MF_01962 |
| Dates | 7-APR-2011 (Created)
3-SEP-2024 (Last updated, Version 13) |
| Name | Adenine_deaminase |
| Scope(s) |
Bacteria |
| Template(s) | Q9I6Y4 (ADE_PSEAE); P53909 (ADE_YEAST); [ Recover all ] |
| Triggered by |
case c? <OC:Bacteria>
HAMAP; MF_01962 (Get profile general information and statistics) end case
|
Propagated annotation
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Identifier, protein and gene names
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| Identifier | ADE |
| Protein name | RecName: Full=Adenine deaminase; Short=ADE; EC=3.5.4.2; AltName: Full=Adenine aminohydrolase; Short=AAH; |
Comments
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| FUNCTION | Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. |
| CATALYTIC ACTIVITY | Reaction=adenine + H2O + H(+) = hypoxanthine + NH4(+); Xref=Rhea:RHEA:23688, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16708, ChEBI:CHEBI:17368, ChEBI:CHEBI:28938; EC=3.5.4.2; |
| case <FTGroup:1> | |
| COFACTOR | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.; |
| end case | |
| SIMILARITY | Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily. |
Keywords
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| Hydrolase | |
| Nucleotide metabolism | |
| case <FTGroup:1> | |
| Metal-binding | |
| Zinc | |
| end case | |
Gene Ontology
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| GO:0000034; Molecular function:adenine deaminase activity | |
| GO:0006146; Biological process:adenine catabolic process | |
| GO:0043103; Biological process:hypoxanthine salvage | |
| case <FTGroup:1> | |
| GO:0008270; Molecular function:zinc ion binding | |
| end case | |
Cross-references
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Features
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| From: ADE_PSEAE (Q9I6Y4) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 197 | 197 | /note="Proton donor" | E | ||||||||
| BINDING | 14 | 14 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic" |
H | 1 | |||||||
| BINDING | 16 | 16 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic" |
H | 1 | |||||||
| BINDING | 194 | 194 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic" |
H | 1 | |||||||
| BINDING | 275 | 275 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic" |
D | 1 | |||||||
| BINDING | 276 | 276 | /ligand="substrate" | D | ||||||||
| SITE | 218 | 218 | /note="Important for catalytic activity" | H | ||||||||
Additional information
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| Size range | 315-367 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |