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HAMAP rule MF_01962

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General rule information [?]

Accession MF_01962
Dates 7-APR-2011 (Created)
1-JUN-2023 (Last updated, Version 12)
Name Adenine_deaminase
Scope(s) Bacteria
Template(s) Q9I6Y4 (ADE_PSEAE); P53909 (ADE_YEAST); [ Recover all ]
Triggered by
case c? <OC:Bacteria>
HAMAP; MF_01962 (Get profile general information and statistics)
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier ADE
Protein name RecName: Full=Adenine deaminase;
AltName: Full=Adenine aminohydrolase;

Comments [?]

FUNCTIONCatalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.
CATALYTIC ACTIVITY Reaction=adenine + H(+) + H2O = hypoxanthine + NH4(+); Xref=Rhea:RHEA:23688, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16708, ChEBI:CHEBI:17368, ChEBI:CHEBI:28938; EC=;
case <FTGroup:1>
COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
end case
SIMILARITYBelongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.

Keywords [?]

Gene Ontology [?]

GO:0000034; Molecular function:adenine deaminase activity
GO:0006146; Biological process:adenine catabolic process
GO:0043103; Biological process:hypoxanthine salvage
case <FTGroup:1>
GO:0008270; Molecular function:zinc ion binding
end case

Cross-references [?]

Pfam PF00962; A_deaminase; 1;
NCBIfam TIGR01430; Aden_deam; 1;

Features [?]

From: ADE_PSEAE (Q9I6Y4)
Key From To Description Tag Condition FTGroup
ACT_SITE 197 197 /note="Proton donor" E
BINDING 14 14 /ligand="Zn(2+)"
H 1
BINDING 16 16 /ligand="Zn(2+)"
H 1
BINDING 194 194 /ligand="Zn(2+)"
H 1
BINDING 275 275 /ligand="Zn(2+)"
D 1
BINDING 276 276 /ligand="substrate" D
SITE 218 218 /note="Important for catalytic activity" H

Additional information [?]

Size range 315-367 amino acids
Related rules None
Fusion Nter: None Cter: None

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