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Annotation rule MF_01962
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General rule information [?]

Accession MF_01962
Dates 7-APR-2011 (Created)
19-NOV-2022 (Last updated, Version 11)
Name Adenine_deaminase
Templates Q9I6Y4 (ADE_PSEAE); P53909 (ADE_YEAST): [Recover all]
case <OC:Bacteria>
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Adenine deaminase;
AltName: Full=Adenine aminohydrolase;

Comments [?]

Function Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.
Catalytic activity RHEA:23688: adenine + H(+) + H2O = hypoxanthine + NH4(+)
case <FTGroup:1>
Cofactor Zn(2+)
Note: Binds 1 zinc ion per subunit.
end case
Similarity Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.

Keywords [?]

case <FTGroup:1>
end case

Gene Ontology [?]

GO:0000034; Molecular function: adenine deaminase activity.
GO:0006146; Biological process: adenine catabolic process.
GO:0043103; Biological process: hypoxanthine salvage.
case <FTGroup:1>
GO:0008270; Molecular function: zinc ion binding.
end case

Cross-references [?]

Pfam PF00962; A_deaminase; 1;
TIGRFAMs TIGR01430; Aden_deam; 1;

Features [?]

From: ADE_PSEAE (Q9I6Y4)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     197     197       Proton donor     E  
BINDING     14     14       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic     H   1
BINDING     16     16       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic     H   1
BINDING     194     194       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic     H   1
BINDING     275     275       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic     D   1
BINDING     276     276       /ligand="substrate     D  
SITE     218     218       Important for catalytic activity     H  

Additional information [?]

Size range 315-367 amino acids
Related rules None
Fusion None