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| Annotation rule MF_01964 |
General rule information
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| Accession | MF_01964 |
| Dates | 5-JAN-2012 (Created) 19-NOV-2019 (Last updated, Version 10) |
| Name | IMPDH |
| Scope | Archaea
Bacteria |
| Templates | P50097 (IMDH_TRIFO); P0C0H6 (IMDH_STRPY); P49058 (IMDH_BORBU); P0ADG7 (IMDH_ECOLI); P9WKI7 (IMDH_MYCTU): [Recover all] |
case <OC:Bacteria> or <OC:Archaea>
| Triggered by |
end case
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. |
| Catalytic activity | RHEA:11708: H2O + IMP + NAD(+) = H(+) + NADH + XMP
EC 1.1.1.205 |
| Cofactor | K(+) |
| Activity regulation | Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH. |
| Pathway | Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1. |
| Subunit | Homotetramer. |
| Similarity | Belongs to the IMPDH/GMPR family. |
Keywords
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Gene Ontology
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GO:0003938; Molecular function: IMP dehydrogenase activity.
GO:0046872; Molecular function: metal ion binding.
GO:0000166; Molecular function: nucleotide binding.
GO:0006177; Biological process: GMP biosynthetic process.
GO:0046872; Molecular function: metal ion binding.
GO:0000166; Molecular function: nucleotide binding.
GO:0006177; Biological process: GMP biosynthetic process.
Cross-references
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| PROSITE | PS51371; CBS; 0-2; trigger=PRU00703; |
| PS00487; IMP_DH_GMP_RED; 1; | |
| Pfam | PF00571; CBS; 2; |
| PF00478; IMPDH; 1; | |
| TIGRFAMs | TIGR01302; IMP_dehydrog; 1; |
| PIRSF | PIRSF000130; IMPDH; 1; |
Features
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| From: IMDH_TRIFO (P50097) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| NP_BIND (Optional) | 261 | 263 | NAD | D-S-S | ||||||||
case not <FT:1=D-S-S>
end case
Additional information
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| Size range | 400-554 amino acids |
| Related rules | None |
| Fusion | None |