HAMAP rule MF_01966

General rule information [?]

Accession	MF_01966
Dates	14-FEB-2012 (Created) 1-JUN-2023 (Last updated, Version 14)

Name	NADHX_epimerase

Scope

Bacteria

Archaea

Templates

Q9X024 (NNR_THEMA); P31806 (NNR_ECOLI): [Recover all]

case <OC:Bacteria> or <OC:Archaea>

Triggered by

end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

NNRE

Protein name

RecName:		Full=NAD(P)H-hydrate epimerase;
		EC 5.1.99.6;
AltName:		Full=NAD(P)HX epimerase;

Gene name

nnrE

Comments [?]

Function	Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
Catalytic activity	RHEA:32215: (6R)-NADHX = (6S)-NADHX EC 5.1.99.6
	RHEA:32227: (6R)-NADPHX = (6S)-NADPHX EC 5.1.99.6
Cofactor	K(+) Note: Binds 1 potassium ion per subunit.
Similarity	Belongs to the NnrE/AIBP family.

Keywords [?]

Gene Ontology [?]

GO:0052856; Molecular function: NADHX epimerase activity.

Cross-references [?]

Features [?]

From: NNR_THEMA (Q9X024)

Key From To Description Tag Condition FTGroup

BINDING 51 55 /ligand="(6S)-NADPHX" /ligand_id="ChEBI:CHEBI:64076 x-N-G-x(2)

BINDING 118 124 /ligand="(6S)-NADPHX" /ligand_id="ChEBI:CHEBI:64076

BINDING 52 52 /ligand="K(+)" /ligand_id="ChEBI:CHEBI:29103 N

BINDING 114 114 /ligand="K(+)" /ligand_id="ChEBI:CHEBI:29103 D

BINDING 150 150 /ligand="K(+)" /ligand_id="ChEBI:CHEBI:29103 [ST]

BINDING (Optional) 129 129 /ligand="(6S)-NADPHX" /ligand_id="ChEBI:CHEBI:64076 Y

BINDING 147 147 /ligand="(6S)-NADPHX" /ligand_id="ChEBI:CHEBI:64076 [DE]

Additional information [?]