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Annotation rule MF_01966
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General rule information [?]

Accession MF_01966
Dates 14-FEB-2012 (Created)
19-NOV-2022 (Last updated, Version 13)
Name NADHX_epimerase
Scope
Bacteria
Archaea
Templates Q9X024 (NNR_THEMA); P31806 (NNR_ECOLI): [Recover all]
case <OC:Bacteria> or <OC:Archaea>
Triggered by
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
NNRE
Protein name
RecName: Full=NAD(P)H-hydrate epimerase;
EC 5.1.99.6;
AltName: Full=NAD(P)HX epimerase;
Gene name
nnrE

Comments [?]

Function Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
Catalytic activity RHEA:32215: (6R)-NADHX = (6S)-NADHX
EC 5.1.99.6
RHEA:32227: (6R)-NADPHX = (6S)-NADPHX
EC 5.1.99.6
Cofactor K(+)
Note: Binds 1 potassium ion per subunit.
Similarity Belongs to the NnrE/AIBP family.

Keywords [?]

Isomerase
Metal-binding
NAD
NADP
Nucleotide-binding
Potassium

Gene Ontology [?]

GO:0052856; Molecular function: NADHX epimerase activity.

Cross-references [?]

PROSITE PS51385; YJEF_N; 1; trigger=PRU00719;
Pfam PF03853; YjeF_N; 1;
TIGRFAMs TIGR00197; YjeF_nterm; 1;

Features [?]

From: NNR_THEMA (Q9X024)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     51     55       /ligand="(6S)-NADPHX" /ligand_id="ChEBI:CHEBI:64076     x-N-G-x(2)  
BINDING     118     124       /ligand="(6S)-NADPHX" /ligand_id="ChEBI:CHEBI:64076        
BINDING     52     52       /ligand="K(+)" /ligand_id="ChEBI:CHEBI:29103     N  
BINDING     114     114       /ligand="K(+)" /ligand_id="ChEBI:CHEBI:29103     D  
BINDING     150     150       /ligand="K(+)" /ligand_id="ChEBI:CHEBI:29103     [ST]  
BINDING (Optional)     129     129       /ligand="(6S)-NADPHX" /ligand_id="ChEBI:CHEBI:64076     Y  
BINDING     147     147       /ligand="(6S)-NADPHX" /ligand_id="ChEBI:CHEBI:64076     [DE]  

Additional information [?]

Size range 204-288 amino acids
Related rules None
Fusion Nter: None; Cter: MF_01965 (nnrD)


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