HAMAP rule MF_01966
General rule information
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Accession | MF_01966 |
Dates | 14-FEB-2012 (Created) 1-JUN-2023 (Last updated, Version 14) |
Name | NADHX_epimerase |
Scope | Bacteria
Archaea |
Templates | Q9X024 (NNR_THEMA); P31806 (NNR_ECOLI): [Recover all] |
case <OC:Bacteria> or <OC:Archaea>
Triggered by |
end case
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. |
Catalytic activity | RHEA:32215: (6R)-NADHX = (6S)-NADHX
EC 5.1.99.6 |
RHEA:32227: (6R)-NADPHX = (6S)-NADPHX
EC 5.1.99.6 |
|
Cofactor | K(+) Note: Binds 1 potassium ion per subunit. |
Similarity | Belongs to the NnrE/AIBP family. |
Keywords
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Gene Ontology
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GO:0052856; Molecular function: NADHX epimerase activity.
Cross-references
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PROSITE | PS51385; YJEF_N; 1; trigger=PRU00719; |
Pfam | PF03853; YjeF_N; 1; |
NCBIfam | TIGR00197; YjeF_nterm; 1; |
Features
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From: NNR_THEMA (Q9X024) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 51 | 55 | /ligand="(6S)-NADPHX" /ligand_id="ChEBI:CHEBI:64076 | x-N-G-x(2) | ||||||||
BINDING | 118 | 124 | /ligand="(6S)-NADPHX" /ligand_id="ChEBI:CHEBI:64076 | |||||||||
BINDING | 52 | 52 | /ligand="K(+)" /ligand_id="ChEBI:CHEBI:29103 | N | ||||||||
BINDING | 114 | 114 | /ligand="K(+)" /ligand_id="ChEBI:CHEBI:29103 | D | ||||||||
BINDING | 150 | 150 | /ligand="K(+)" /ligand_id="ChEBI:CHEBI:29103 | [ST] | ||||||||
BINDING (Optional) | 129 | 129 | /ligand="(6S)-NADPHX" /ligand_id="ChEBI:CHEBI:64076 | Y | ||||||||
BINDING | 147 | 147 | /ligand="(6S)-NADPHX" /ligand_id="ChEBI:CHEBI:64076 | [DE] |
Additional information
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Size range | 204-288 amino acids |
Related rules | None |
Fusion | Nter: None; Cter: MF_01965 (nnrD) |