HAMAP rule MF_01966
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_01966 |
| Accession | MF_01966 |
| Dates | 14-FEB-2012 (Created)
5-NOV-2024 (Last updated, Version 15) |
| Name | NADHX_epimerase |
| Scope(s) |
Bacteria Archaea |
| Template(s) | Q9X024 (NNR_THEMA); P31806 (NNR_ECOLI); [ Recover all ] |
| Triggered by |
case c? <OC:Bacteria> or <OC:Archaea>
HAMAP; MF_01966 (Get profile general information and statistics) end case
|
Propagated annotation
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Identifier, protein and gene names
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| Identifier | NNRE |
| Protein name | RecName: Full=NAD(P)H-hydrate epimerase; EC=5.1.99.6; AltName: Full=NAD(P)HX epimerase; |
| Gene name | Name=nnrE; |
Comments
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| FUNCTION | Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. |
| CATALYTIC ACTIVITY | Reaction=(6R)-NADHX = (6S)-NADHX; Xref=Rhea:RHEA:32215, ChEBI:CHEBI:64074, ChEBI:CHEBI:64075; EC=5.1.99.6; |
| CATALYTIC ACTIVITY | Reaction=(6R)-NADPHX = (6S)-NADPHX; Xref=Rhea:RHEA:32227, ChEBI:CHEBI:64076, ChEBI:CHEBI:64077; EC=5.1.99.6; |
| COFACTOR | Name=K(+); Xref=ChEBI:CHEBI:29103; Note=Binds 1 potassium ion per subunit.; |
| SIMILARITY | Belongs to the NnrE/AIBP family. |
Keywords
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Gene Ontology
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| GO:0052856; Molecular function:NAD(P)HX epimerase activity |
Cross-references
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Features
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| From: NNR_THEMA (Q9X024) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 51 | 55 | /ligand="(6S)-NADPHX" /ligand_id="ChEBI:CHEBI:64076" |
x-N-G-x(2) | ||||||||
| BINDING | 118 | 124 | /ligand="(6S)-NADPHX" /ligand_id="ChEBI:CHEBI:64076" |
|||||||||
| BINDING | 52 | 52 | /ligand="K(+)" /ligand_id="ChEBI:CHEBI:29103" |
N | ||||||||
| BINDING | 114 | 114 | /ligand="K(+)" /ligand_id="ChEBI:CHEBI:29103" |
D | ||||||||
| BINDING | 150 | 150 | /ligand="K(+)" /ligand_id="ChEBI:CHEBI:29103" |
[ST] | ||||||||
| BINDING | 129 | 129 | /ligand="(6S)-NADPHX" /ligand_id="ChEBI:CHEBI:64076" |
Y | ||||||||
| BINDING | 147 | 147 | /ligand="(6S)-NADPHX" /ligand_id="ChEBI:CHEBI:64076" |
[DE] | ||||||||
Additional information
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| Size range | 204-288 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: MF_01965 (nnrD) |