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HAMAP rule MF_01966

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General rule information [?]

Accession MF_01966
Dates 14-FEB-2012 (Created)
1-JUN-2023 (Last updated, Version 14)
Name NADHX_epimerase
Scope(s) Bacteria
Template(s) Q9X024 (NNR_THEMA); P31806 (NNR_ECOLI); [ Recover all ]
Triggered by
case c? <OC:Bacteria> or <OC:Archaea>
HAMAP; MF_01966 (Get profile general information and statistics)
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier NNRE
Protein name RecName: Full=NAD(P)H-hydrate epimerase;
AltName: Full=NAD(P)HX epimerase;
Gene name Name=nnrE;

Comments [?]

FUNCTIONCatalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
CATALYTIC ACTIVITY Reaction=(6R)-NADHX = (6S)-NADHX; Xref=Rhea:RHEA:32215, ChEBI:CHEBI:64074, ChEBI:CHEBI:64075; EC=;
CATALYTIC ACTIVITY Reaction=(6R)-NADPHX = (6S)-NADPHX; Xref=Rhea:RHEA:32227, ChEBI:CHEBI:64076, ChEBI:CHEBI:64077; EC=;
COFACTOR Name=K(+); Xref=ChEBI:CHEBI:29103; Note=Binds 1 potassium ion per subunit.;
SIMILARITYBelongs to the NnrE/AIBP family.

Keywords [?]

Gene Ontology [?]

GO:0052856; Molecular function:NADHX epimerase activity

Cross-references [?]

Pfam PF03853; YjeF_N; 1;
NCBIfam TIGR00197; YjeF_nterm; 1;

Features [?]

From: NNR_THEMA (Q9X024)
Key From To Description Tag Condition FTGroup
BINDING 51 55 /ligand="(6S)-NADPHX"
BINDING 118 124 /ligand="(6S)-NADPHX"
BINDING 52 52 /ligand="K(+)"
BINDING 114 114 /ligand="K(+)"
BINDING 150 150 /ligand="K(+)"
BINDING 129 129 /ligand="(6S)-NADPHX"
BINDING 147 147 /ligand="(6S)-NADPHX"

Additional information [?]

Size range 204-288 amino acids
Related rules None
Fusion Nter: None Cter: MF_01965 (nnrD)

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