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Annotation rule MF_01966 |
General rule information
[?]
Accession |
MF_01966 |
Dates |
14-FEB-2012 (Created) 19-NOV-2022 (Last updated, Version 13) |
case <OC:Bacteria> or <OC:Archaea>
end case
Propagated annotation
[?]
Identifier, protein and gene names
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Protein name |
RecName:
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Full=NAD(P)H-hydrate epimerase;
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EC 5.1.99.6;
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AltName:
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Full=NAD(P)HX epimerase;
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Function |
Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. |
Catalytic activity |
RHEA:32215: (6R)-NADHX = (6S)-NADHX
EC 5.1.99.6
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RHEA:32227: (6R)-NADPHX = (6S)-NADPHX
EC 5.1.99.6
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Cofactor |
K(+) Note: Binds 1 potassium ion per subunit. |
Similarity |
Belongs to the NnrE/AIBP family. |
GO:0052856; Molecular function: NADHX epimerase activity.
From: NNR_THEMA (Q9X024) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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BINDING
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51
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55
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/ligand="(6S)-NADPHX" /ligand_id="ChEBI:CHEBI:64076
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x-N-G-x(2)
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BINDING
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118
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124
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/ligand="(6S)-NADPHX" /ligand_id="ChEBI:CHEBI:64076
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BINDING
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52
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52
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/ligand="K(+)" /ligand_id="ChEBI:CHEBI:29103
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N
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BINDING
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114
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114
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/ligand="K(+)" /ligand_id="ChEBI:CHEBI:29103
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D
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BINDING
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150
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150
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/ligand="K(+)" /ligand_id="ChEBI:CHEBI:29103
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[ST]
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BINDING (Optional)
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129
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129
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/ligand="(6S)-NADPHX" /ligand_id="ChEBI:CHEBI:64076
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Y
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BINDING
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147
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147
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/ligand="(6S)-NADPHX" /ligand_id="ChEBI:CHEBI:64076
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[DE]
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Additional information
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Size range |
204-288 amino acids |
Related rules |
None |
Fusion |
Nter: None; Cter: MF_01965 (nnrD) |