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HAMAP rule MF_01970

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General rule information [?]

Accession MF_01970
Dates 12-FEB-2009 (Created)
1-JUN-2023 (Last updated, Version 13)
Name Kynureninase
Scope
Bacteria
Template P83788 (KYNU_PSEFL)
case <OC:Bacteria>
Triggered by
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
KYNU
Protein name
RecName: Full=Kynureninase;
EC 3.7.1.3;
AltName: Full=L-kynurenine hydrolase;
Gene name
kynU

Comments [?]

Function Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
Catalytic activity RHEA:16813: H2O + L-kynurenine = anthranilate + H(+) + L-alanine
EC 3.7.1.3
RHEA:25143: 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + H(+) + L-alanine
case <FTTag:PLP>
Cofactor pyridoxal 5'-phosphate
end case
Pathway Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1.
Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3.
Subunit Homodimer.
Similarity Belongs to the kynureninase family.

Keywords [?]

Hydrolase
Pyridine nucleotide biosynthesis
case <FTTag:PLP>
Pyridoxal phosphate
end case

Gene Ontology [?]

GO:0030170; Molecular function: pyridoxal phosphate binding.
GO:0030429; Molecular function: kynureninase activity.
GO:0006569; Biological process: tryptophan catabolic process.
GO:0019805; Biological process: quinolinate biosynthetic process.
GO:0034354; Biological process: 'de novo' NAD biosynthetic process from tryptophan.
GO:0043420; Biological process: anthranilate metabolic process.

Cross-references [?]

Pfam PF00266; Aminotran_5; 1;
PIRSF PIRSF038800; KYNU; 1;
NCBIfam TIGR01814; Kynureninase; 1;

Features [?]

From: KYNU_PSEFL (P83788)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     129     132       /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326     F-P-[ST]-D  
BINDING     97     97       /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326     [TIL]  
BINDING     98     98       /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326     [ST]  
BINDING (Optional)     172     172       /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326     T  
BINDING     201     201       /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326     D  
BINDING     204     204       /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326     H  
BINDING     226     226       /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326     Y  
MOD_RES     227     227       N6-(pyridoxal phosphate)lysine   PLP   K  
BINDING     256     256       /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326     W  
BINDING     282     282       /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326     [TN]  

Additional information [?]

Size range 410-539 amino acids
Related rules None
Fusion None


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