HAMAP rule MF_01972
General rule information
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| Accession | MF_01972 |
| Dates | 12-FEB-2009 (Created)
12-MAR-2024 (Last updated, Version 15) |
| Name | T23O |
| Scope(s) |
Bacteria |
| Template(s) | Q8PDA8 (T23O_XANCP); Q84HF6 (T23O_PSEFL); [ Recover all ] |
| Triggered by |
case c? <OC:Bacteria>
HAMAP; MF_01972 (Get profile general information and statistics) end case
|
Propagated annotation
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Identifier, protein and gene names
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| Identifier | T23O |
| Protein name | RecName: Full=Tryptophan 2,3-dioxygenase; Short=TDO; EC=1.13.11.11; AltName: Full=Tryptamin 2,3-dioxygenase; AltName: Full=Tryptophan oxygenase; Short=TO; Short=TRPO; AltName: Full=Tryptophan pyrrolase; AltName: Full=Tryptophanase; |
| Gene name | Name=kynA; |
Comments
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| FUNCTION | Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. |
| CATALYTIC ACTIVITY | Reaction=L-tryptophan + O2 = N-formyl-L-kynurenine; Xref=Rhea:RHEA:24536, ChEBI:CHEBI:15379, ChEBI:CHEBI:57912, ChEBI:CHEBI:58629; EC=1.13.11.11; |
| COFACTOR | Name=heme; Xref=ChEBI:CHEBI:30413; Note=Binds 1 heme group per subunit.; |
| PATHWAY | Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2. |
| SUBUNIT | Homotetramer. |
| SIMILARITY | Belongs to the tryptophan 2,3-dioxygenase family. |
Keywords
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Gene Ontology
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| GO:0004833; Molecular function:tryptophan 2,3-dioxygenase activity |
| GO:0020037; Molecular function:heme binding |
| GO:0019441; Biological process:tryptophan catabolic process to kynurenine |
Cross-references
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| Pfam | PF03301; Trp_dioxygenase; 1; |
| NCBIfam | TIGR03036; Trp_2_3_diox; 1; |
| PROSITE | PS50312; ASP_RICH; 0-unlimited; |
| PROSITE | PS50313; GLU_RICH; 0-unlimited; |
| PROSITE | PS50318; LYS_RICH; 0-unlimited; |
| PROSITE | PS50323; ARG_RICH; 0-unlimited; |
| General | Coiled_coil; -; 0-unlimited; |
Features
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| From: T23O_XANCP (Q8PDA8) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 51 | 55 | /ligand="substrate" | F-[IV]-[IVT]-[IVQT]-H | ||||||||
| BINDING | 240 | 240 | /ligand="heme" /ligand_id="ChEBI:CHEBI:30413" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue" |
H | ||||||||
| BINDING | 113 | 113 | /ligand="substrate" | Y | ||||||||
| BINDING | 117 | 117 | /ligand="substrate" | R | ||||||||
| BINDING | 254 | 254 | /ligand="substrate" | T | ||||||||
Additional information
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| Size range | 260-412 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |