HAMAP logo

HAMAP rule MF_01972

Send feedback

General rule information [?]

Accession MF_01972
Dates 12-FEB-2009 (Created)
12-MAR-2024 (Last updated, Version 15)
Name T23O
Scope(s) Bacteria
Template(s) Q8PDA8 (T23O_XANCP); Q84HF6 (T23O_PSEFL); [ Recover all ]
Triggered by
case c? <OC:Bacteria>
HAMAP; MF_01972 (Get profile general information and statistics)
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier T23O
Protein name RecName: Full=Tryptophan 2,3-dioxygenase;
AltName: Full=Tryptamin 2,3-dioxygenase;
AltName: Full=Tryptophan oxygenase;
AltName: Full=Tryptophan pyrrolase;
AltName: Full=Tryptophanase;
Gene name Name=kynA;

Comments [?]

FUNCTIONHeme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
CATALYTIC ACTIVITY Reaction=L-tryptophan + O2 = N-formyl-L-kynurenine; Xref=Rhea:RHEA:24536, ChEBI:CHEBI:15379, ChEBI:CHEBI:57912, ChEBI:CHEBI:58629; EC=;
COFACTOR Name=heme; Xref=ChEBI:CHEBI:30413; Note=Binds 1 heme group per subunit.;
PATHWAYAmino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.
SIMILARITYBelongs to the tryptophan 2,3-dioxygenase family.

Keywords [?]

Gene Ontology [?]

GO:0004833; Molecular function:tryptophan 2,3-dioxygenase activity
GO:0020037; Molecular function:heme binding
GO:0019441; Biological process:tryptophan catabolic process to kynurenine

Cross-references [?]

Pfam PF03301; Trp_dioxygenase; 1;
NCBIfam TIGR03036; Trp_2_3_diox; 1;
PROSITE PS50312; ASP_RICH; 0-unlimited;
PROSITE PS50313; GLU_RICH; 0-unlimited;
PROSITE PS50318; LYS_RICH; 0-unlimited;
PROSITE PS50323; ARG_RICH; 0-unlimited;
General Coiled_coil; -; 0-unlimited;

Features [?]

From: T23O_XANCP (Q8PDA8)
Key From To Description Tag Condition FTGroup
BINDING 51 55 /ligand="substrate" F-[IV]-[IVT]-[IVQT]-H
BINDING 240 240 /ligand="heme"
/note="axial binding residue"
BINDING 113 113 /ligand="substrate" Y
BINDING 117 117 /ligand="substrate" R
BINDING 254 254 /ligand="substrate" T

Additional information [?]

Size range 260-412 amino acids
Related rules None
Fusion Nter: None Cter: None

View rule in raw text format (no links)