HAMAP rule MF_01972

General rule information [?]

Accession	MF_01972
Dates	12-FEB-2009 (Created) 1-JUN-2023 (Last updated, Version 13)

Name

T23O

Scope

Bacteria

Templates

Q8PDA8 (T23O_XANCP); Q84HF6 (T23O_PSEFL): [Recover all]

case <OC:Bacteria>

Triggered by

HAMAP; MF_01972 (Get profile general information and statistics)

end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

T23O

Protein name

RecName:		Full=Tryptophan 2,3-dioxygenase;
		Short=TDO;
		EC 1.13.11.11;
AltName:		Full=Tryptamin 2,3-dioxygenase;
AltName:		Full=Tryptophan oxygenase;
		Short=TO;
		Short=TRPO;
AltName:		Full=Tryptophan pyrrolase;
AltName:		Full=Tryptophanase;

Gene name

kynA

Comments [?]

Function	Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
Catalytic activity	RHEA:24536: L-tryptophan + O2 = N-formyl-L-kynurenine EC 1.13.11.11
Cofactor	heme Note: Binds 1 heme group per subunit.
Pathway	Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.
Subunit	Homotetramer.
Similarity	Belongs to the tryptophan 2,3-dioxygenase family.

Keywords [?]

Dioxygenase
Heme
Iron
Metal-binding
Oxidoreductase
Tryptophan catabolism

Gene Ontology [?]

GO:0004833; Molecular function: tryptophan 2,3-dioxygenase activity.
GO:0020037; Molecular function: heme binding.
GO:0006569; Biological process: tryptophan catabolic process.

Cross-references [?]

Pfam	PF03301; Trp_dioxygenase; 1;
NCBIfam	TIGR03036; Trp_2_3_diox; 1;
PROSITE	PS50312; ASP_RICH; 0-unlimited;
	PS50313; GLU_RICH; 0-unlimited;
	PS50318; LYS_RICH; 0-unlimited;
	PS50323; ARG_RICH; 0-unlimited;

Computed features [?]

General

Coiled_coil; -; 0-unlimited;

Features [?]

From: T23O_XANCP (Q8PDA8)

Key From To Description Tag Condition FTGroup

BINDING 51 55 /ligand="substrate F-[IV]-[IVT]-[IVQT]-H

BINDING 240 240 /ligand="heme" /ligand_id="ChEBI:CHEBI:30413" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue H

BINDING (Optional) 113 113 /ligand="substrate Y

BINDING 117 117 /ligand="substrate R

BINDING 254 254 /ligand="substrate T

Additional information [?]

Size range	260-412 amino acids
Related rules	None
Fusion	None

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