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HAMAP rule MF_01972

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General rule information [?]

Accession MF_01972
Dates 12-FEB-2009 (Created)
1-JUN-2023 (Last updated, Version 13)
Name T23O
Templates Q8PDA8 (T23O_XANCP); Q84HF6 (T23O_PSEFL): [Recover all]
case <OC:Bacteria>
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Tryptophan 2,3-dioxygenase;
AltName: Full=Tryptamin 2,3-dioxygenase;
AltName: Full=Tryptophan oxygenase;
AltName: Full=Tryptophan pyrrolase;
AltName: Full=Tryptophanase;
Gene name

Comments [?]

Function Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
Catalytic activity RHEA:24536: L-tryptophan + O2 = N-formyl-L-kynurenine
Cofactor heme
Note: Binds 1 heme group per subunit.
Pathway Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.
Subunit Homotetramer.
Similarity Belongs to the tryptophan 2,3-dioxygenase family.

Keywords [?]

Gene Ontology [?]

GO:0004833; Molecular function: tryptophan 2,3-dioxygenase activity.
GO:0020037; Molecular function: heme binding.
GO:0006569; Biological process: tryptophan catabolic process.

Cross-references [?]

Pfam PF03301; Trp_dioxygenase; 1;
NCBIfam TIGR03036; Trp_2_3_diox; 1;
PROSITE PS50312; ASP_RICH; 0-unlimited;
PS50313; GLU_RICH; 0-unlimited;
PS50318; LYS_RICH; 0-unlimited;
PS50323; ARG_RICH; 0-unlimited;

Computed features [?]

General Coiled_coil; -; 0-unlimited;

Features [?]

From: T23O_XANCP (Q8PDA8)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     51     55       /ligand="substrate     F-[IV]-[IVT]-[IVQT]-H  
BINDING     240     240       /ligand="heme" /ligand_id="ChEBI:CHEBI:30413" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue     H  
BINDING (Optional)     113     113       /ligand="substrate     Y  
BINDING     117     117       /ligand="substrate     R  
BINDING     254     254       /ligand="substrate     T  

Additional information [?]

Size range 260-412 amino acids
Related rules None
Fusion None