HAMAP rule MF_01983
General rule information
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| Accession | MF_01983 |
| Dates | 1-SEP-2015 (Created)
19-SEP-2024 (Last updated, Version 10) |
| Name | UbiD_FDC |
| Scope(s) |
Bacteria |
| Template(s) | Q9I6N5 (P2CDC_PSEAE); Q03034 (FDC1_YEAST); [ Recover all ] |
| Triggered by |
case c? <OC:Bacteria>
HAMAP; MF_01983 (Get profile general information and statistics) end case
|
Propagated annotation
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Identifier, protein and gene names
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| Identifier | P2CDC |
| Protein name | RecName: Full=Pyrrole-2-carboxylic acid decarboxylase; Short=P2C decarboxylase; EC=4.1.1.93; |
Comments
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| FUNCTION | Catalyzes the prenyl-FMN-dependent decarboxylation of pyrrole-2-carboxylate (P2C). Can also catalyze the carboxylation of pyrrole in the presence of elevated concentrations of CO(2) or bicarbonate. |
| CATALYTIC ACTIVITY | Reaction=pyrrole-2-carboxylate + H(+) = 1H-pyrrole + CO2; Xref=Rhea:RHEA:31375, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:19203, ChEBI:CHEBI:27660; EC=4.1.1.93; |
| CATALYTIC ACTIVITY | Reaction=pyrrole-2-carboxylate + H2O = 1H-pyrrole + hydrogencarbonate; Xref=Rhea:RHEA:31379, ChEBI:CHEBI:15377, ChEBI:CHEBI:17544, ChEBI:CHEBI:19203, ChEBI:CHEBI:27660; EC=4.1.1.93; |
| COFACTOR | Name=prenylated FMN; Xref=ChEBI:CHEBI:87746; Note=Binds 1 prenylated FMN per subunit.; |
| COFACTOR | Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 1 Mn(2+) per subunit.; |
| COFACTOR | Name=K(+); Xref=ChEBI:CHEBI:29103; Note=Binds 1 K(+) per subunit.; |
| SUBUNIT | Homodimer. |
| SIMILARITY | Belongs to the UbiD family. UbiD-like/FDC subfamily. |
Keywords
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| Aromatic hydrocarbons catabolism |
| Decarboxylase |
| FMN |
| Flavoprotein |
| Lyase |
| Manganese |
| Metal-binding |
| Potassium |
Gene Ontology
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| GO:0016831; Molecular function:carboxy-lyase activity |
Cross-references
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Features
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| From: P2CDC_PSEAE (Q9I6N5) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 278 | 278 | /note="Proton donor" | E | ||||||||
| BINDING | 166 | 166 | /ligand="K(+)" /ligand_id="ChEBI:CHEBI:29103" |
W | ||||||||
| BINDING | 168 | 168 | /ligand="prenyl-FMN" /ligand_id="ChEBI:CHEBI:87746" |
V | ||||||||
| BINDING | 170 | 170 | /ligand="prenyl-FMN" /ligand_id="ChEBI:CHEBI:87746" |
R | ||||||||
| BINDING | 187 | 187 | /ligand="prenyl-FMN" /ligand_id="ChEBI:CHEBI:87746" |
Q | ||||||||
| BINDING | 188 | 188 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" |
H | ||||||||
| BINDING | 188 | 188 | /ligand="prenyl-FMN" /ligand_id="ChEBI:CHEBI:87746" |
H | ||||||||
| BINDING | 218 | 218 | /ligand="K(+)" /ligand_id="ChEBI:CHEBI:29103" |
A | ||||||||
| BINDING | 219 | 219 | /ligand="K(+)" /ligand_id="ChEBI:CHEBI:29103" |
A | ||||||||
| BINDING | 221 | 221 | /ligand="K(+)" /ligand_id="ChEBI:CHEBI:29103" |
M | ||||||||
| BINDING | 229 | 229 | /ligand="K(+)" /ligand_id="ChEBI:CHEBI:29103" |
E | ||||||||
| BINDING | 229 | 229 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" |
E | ||||||||
| BINDING | 229 | 229 | /ligand="prenyl-FMN" /ligand_id="ChEBI:CHEBI:87746" |
E | ||||||||
| BINDING | 386 | 386 | /ligand="prenyl-FMN" /ligand_id="ChEBI:CHEBI:87746" |
H | ||||||||
Additional information
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| Size range | 485-507 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |