Home  |  Contact
Annotation rule MF_02001
Send feedback

General rule information [?]

Accession MF_02001
Dates 28-JUL-2005 (Created)
20-NOV-2019 (Last updated, Version 15)
Name HSP20_IbpB
Bacteria; Enterobacterales
Template P0C058 (IBPB_ECOLI)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Small heat shock protein IbpB;
AltName: Full=16 kDa heat shock protein B;
Gene name

Comments [?]

Function Associates with aggregated proteins, together with IbpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE. Its activity is ATP-independent.
Subunit Homodimer. Forms homomultimers of about 100-150 subunits at optimal growth temperatures. Conformation changes to oligomers at high temperatures or high ionic concentrations. The decrease in size of the multimers is accompanied by an increase in chaperone activity.
Subcellular location Cytoplasm.
Domain The N- and C-terminal flexible termini are involved in oligomerization and in the binding of non-native substrate proteins, and are essential for chaperone activity.
Similarity Belongs to the small heat shock protein (HSP20) family.

Keywords [?]

Gene Ontology [?]

GO:0050821; Biological process: protein stabilization.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00011; HSP20; 1;
PROSITE PS01031; SHSP; 1; trigger=PRU00285;

Additional information [?]

Size range 140-170 amino acids
Related rules None
Fusion None