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HAMAP rule MF_02001

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General rule information [?]

Accession MF_02001
Dates 28-JUL-2005 (Created)
20-NOV-2019 (Last updated, Version 15)
Name HSP20_IbpB
Scope(s) Bacteria
Template(s) P0C058 (IBPB_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_02001 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier IBPB
Protein name RecName: Full=Small heat shock protein IbpB;
AltName: Full=16 kDa heat shock protein B;
Gene name Name=ibpB;

Comments [?]

FUNCTIONAssociates with aggregated proteins, together with IbpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE. Its activity is ATP-independent.
SUBUNITHomodimer. Forms homomultimers of about 100-150 subunits at optimal growth temperatures. Conformation changes to oligomers at high temperatures or high ionic concentrations. The decrease in size of the multimers is accompanied by an increase in chaperone activity.
DOMAINThe N- and C-terminal flexible termini are involved in oligomerization and in the binding of non-native substrate proteins, and are essential for chaperone activity.
SIMILARITYBelongs to the small heat shock protein (HSP20) family.

Keywords [?]

Gene Ontology [?]

GO:0050821; Biological process:protein stabilization
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF00011; HSP20; 1;

Features [?]

Additional information [?]

Size range 140-170 amino acids
Related rules None
Fusion Nter: None Cter: None

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