HAMAP rule MF_02001

General rule information [?]

Accession	MF_02001
Dates	28-JUL-2005 (Created) 20-NOV-2019 (Last updated, Version 15)
Name	HSP20_IbpB
Scope(s)	Bacteria Enterobacterales
Template(s)	P0C058 (IBPB_ECOLI); [ Recover all ]
Triggered by	HAMAP; MF_02001 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	IBPB
Protein name	RecName: Full=Small heat shock protein IbpB; AltName: Full=16 kDa heat shock protein B;
Gene name	Name=ibpB;

Comments [?]

FUNCTION	Associates with aggregated proteins, together with IbpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE. Its activity is ATP-independent.
SUBUNIT	Homodimer. Forms homomultimers of about 100-150 subunits at optimal growth temperatures. Conformation changes to oligomers at high temperatures or high ionic concentrations. The decrease in size of the multimers is accompanied by an increase in chaperone activity.
SUBCELLULAR LOCATION	Cytoplasm.
DOMAIN	The N- and C-terminal flexible termini are involved in oligomerization and in the binding of non-native substrate proteins, and are essential for chaperone activity.
SIMILARITY	Belongs to the small heat shock protein (HSP20) family.

Keywords [?]

Gene Ontology [?]

GO:0050821; Biological process:protein stabilization

GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam	PF00011; HSP20; 1;
PROSITE	PS01031; SHSP; 1;

Features [?]

Additional information [?]