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HAMAP rule MF_02012

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General rule information [?]

Accession MF_02012
Dates 27-JUN-2008 (Created)
20-NOV-2019 (Last updated, Version 9)
Name ZapA_type1
Scope(s) Bacteria
Template(s) P0ADS2 (ZAPA_ECOLI); Q9HTW3 (ZAPA_PSEAE); [ Recover all ]
Triggered by HAMAP; MF_02012 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier ZAPA
Protein name RecName: Full=Cell division protein ZapA;
AltName: Full=Z ring-associated protein ZapA;
Gene name Name=zapA;

Comments [?]

FUNCTIONActivator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division.
SUBUNITHomodimer. Interacts with FtsZ.
SUBCELLULAR LOCATIONCytoplasm. Note=Localizes at mid-cell.
SIMILARITYBelongs to the ZapA family. Type 1 subfamily.

Keywords [?]

Gene Ontology [?]

GO:0005886; Cellular component:plasma membrane
GO:0051301; Biological process:cell division
GO:0090529; Biological process:cell septum assembly

Cross-references [?]

Pfam PF05164; ZapA; 1;
General Coiled_coil; -; 1-unlimited;

Features [?]

Additional information [?]

Size range 104-109 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments Due to the high divergence of ZapA sequences, this family includes mostly members from the enterobacteria. There is a 3D-structure available for ZapA from Pseudomonas aeruginosa; this protein is not a member of this family though it probably has the same function; the information derived from the structure was included in this rule.

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