HAMAP rule MF_02012
General rule information
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| Accession | MF_02012 |
| Dates | 27-JUN-2008 (Created)
20-NOV-2019 (Last updated, Version 9) |
| Name | ZapA_type1 |
| Scope(s) |
Bacteria Gammaproteobacteria |
| Template(s) | P0ADS2 (ZAPA_ECOLI); Q9HTW3 (ZAPA_PSEAE); [ Recover all ] |
| Triggered by |
HAMAP; MF_02012 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | ZAPA |
| Protein name | RecName: Full=Cell division protein ZapA; AltName: Full=Z ring-associated protein ZapA; |
| Gene name | Name=zapA; |
Comments
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| FUNCTION | Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division. |
| SUBUNIT | Homodimer. Interacts with FtsZ. |
| SUBCELLULAR LOCATION | Cytoplasm. Note=Localizes at mid-cell. |
| SIMILARITY | Belongs to the ZapA family. Type 1 subfamily. |
Keywords
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Gene Ontology
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| GO:0005886; Cellular component:plasma membrane |
| GO:0051301; Biological process:cell division |
| GO:0090529; Biological process:cell septum assembly |
Cross-references
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| Pfam | PF05164; ZapA; 1; |
| General | Coiled_coil; -; 1-unlimited; |
Features
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Additional information
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| Size range | 104-109 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | Due to the high divergence of ZapA sequences, this family includes mostly members from the enterobacteria. There is a 3D-structure available for ZapA from Pseudomonas aeruginosa; this protein is not a member of this family though it probably has the same function; the information derived from the structure was included in this rule. |