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HAMAP rule MF_02028

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General rule information [?]

Accession MF_02028
Dates 6-MAY-2015 (Created)
1-JUN-2023 (Last updated, Version 7)
Name WecB_RffE
Scope(s) Bacteria
Template(s) P27828 (WECB_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_02028 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier WECB
Protein name RecName: Full=UDP-N-acetylglucosamine 2-epimerase;
AltName: Full=UDP-GlcNAc-2-epimerase;
Gene name Name=wecB;

Comments [?]

FUNCTIONCatalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP- N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues.
CATALYTIC ACTIVITY Reaction=UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D- mannosamine; Xref=Rhea:RHEA:17213, ChEBI:CHEBI:57705, ChEBI:CHEBI:68623; EC=;
PATHWAYBacterial outer membrane biogenesis; enterobacterial common antigen biosynthesis.
SIMILARITYBelongs to the UDP-N-acetylglucosamine 2-epimerase family.

Keywords [?]

Gene Ontology [?]

GO:0008761; Molecular function:UDP-N-acetylglucosamine 2-epimerase activity
GO:0009246; Biological process:enterobacterial common antigen biosynthetic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF02350; Epimerase_2; 1;
NCBIfam TIGR00236; wecB; 1;

Features [?]

From: WECB_ECOLI (P27828)
Key From To Description Tag Condition FTGroup
BINDING 290 292 /ligand="substrate" S-G-G
BINDING 10 10 /ligand="substrate" R
BINDING 15 15 /ligand="substrate" K
BINDING 95 95 /ligand="substrate" D
BINDING 117 117 /ligand="substrate" E
BINDING 213 213 /ligand="substrate" H
BINDING 271 271 /ligand="substrate" Q
BINDING 276 276 /ligand="substrate" F
BINDING 296 296 /ligand="substrate" E
BINDING 313 313 /ligand="substrate" R

Additional information [?]

Size range 335-400 amino acids
Related rules None
Fusion Nter: None Cter: None

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