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Annotation rule MF_02028
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General rule information [?]

Accession MF_02028
Dates 6-MAY-2015 (Created)
20-NOV-2019 (Last updated, Version 4)
Name WecB_RffE
Scope
Bacteria; Enterobacterales
Template P27828 (WECB_ECOLI)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
WECB
Protein name
RecName: Full=UDP-N-acetylglucosamine 2-epimerase;
EC 5.1.3.14;
AltName: Full=UDP-GlcNAc-2-epimerase;
Gene name
wecB

Comments [?]

Function Catalyzes the reversible epimerization at C-2 of UDP-N-acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues.
Catalytic activity RHEA:17213: UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D-mannosamine
EC 5.1.3.14
Pathway Bacterial outer membrane biogenesis; enterobacterial common antigen biosynthesis.
Subunit Homodimer.
Subcellular location Cytoplasm.
Similarity Belongs to the UDP-N-acetylglucosamine 2-epimerase family.

Keywords [?]


Gene Ontology [?]

GO:0008761; Molecular function: UDP-N-acetylglucosamine 2-epimerase activity.
GO:0009246; Biological process: enterobacterial common antigen biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF02350; Epimerase_2; 1;
TIGRFAMs TIGR00236; wecB; 1;

Features [?]

From: WECB_ECOLI (P27828)
Key     From     To       Description   Tag   Condition   FTGroup
REGION (Optional)     290     292       Substrate binding     S-G-G  
BINDING (Optional)     10     10       Substrate     R  
BINDING (Optional)     15     15       Substrate     K  
BINDING (Optional)     95     95       Substrate     D  
BINDING (Optional)     117     117       Substrate     E  
BINDING (Optional)     213     213       Substrate     H  
BINDING (Optional)     271     271       Substrate; via amide nitrogen and carbonyl oxygen     Q  
BINDING (Optional)     276     276       Substrate     F  
BINDING (Optional)     296     296       Substrate     E  
BINDING (Optional)     313     313       Substrate     R  

Additional information [?]

Size range 335-400 amino acids
Related rules None
Fusion None