HAMAP rule MF_02028
General rule information
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| Accession | MF_02028 |
| Dates | 6-MAY-2015 (Created)
1-JUN-2023 (Last updated, Version 7) |
| Name | WecB_RffE |
| Scope(s) |
Bacteria Enterobacterales |
| Template(s) | P27828 (WECB_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_02028 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | WECB |
| Protein name | RecName: Full=UDP-N-acetylglucosamine 2-epimerase; EC=5.1.3.14; AltName: Full=UDP-GlcNAc-2-epimerase; |
| Gene name | Name=wecB; |
Comments
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| FUNCTION | Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP- N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues. |
| CATALYTIC ACTIVITY | Reaction=UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D- mannosamine; Xref=Rhea:RHEA:17213, ChEBI:CHEBI:57705, ChEBI:CHEBI:68623; EC=5.1.3.14; |
| PATHWAY | Bacterial outer membrane biogenesis; enterobacterial common antigen biosynthesis. |
| SUBUNIT | Homodimer. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the UDP-N-acetylglucosamine 2-epimerase family. |
Keywords
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Gene Ontology
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| GO:0008761; Molecular function:UDP-N-acetylglucosamine 2-epimerase activity |
| GO:0009246; Biological process:enterobacterial common antigen biosynthetic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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Features
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| From: WECB_ECOLI (P27828) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 290 | 292 | /ligand="substrate" | S-G-G | ||||||||
| BINDING | 10 | 10 | /ligand="substrate" | R | ||||||||
| BINDING | 15 | 15 | /ligand="substrate" | K | ||||||||
| BINDING | 95 | 95 | /ligand="substrate" | D | ||||||||
| BINDING | 117 | 117 | /ligand="substrate" | E | ||||||||
| BINDING | 213 | 213 | /ligand="substrate" | H | ||||||||
| BINDING | 271 | 271 | /ligand="substrate" | Q | ||||||||
| BINDING | 276 | 276 | /ligand="substrate" | F | ||||||||
| BINDING | 296 | 296 | /ligand="substrate" | E | ||||||||
| BINDING | 313 | 313 | /ligand="substrate" | R | ||||||||
Additional information
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| Size range | 335-400 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |