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Annotation rule MF_02030
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General rule information [?]

Accession MF_02030
Dates 13-MAY-2015 (Created)
4-NOV-2020 (Last updated, Version 5)
Name WecA_Gammaproteo
Scope
Bacteria; Gammaproteobacteria
Template P0AC78 (WECA_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
WECA
Protein name
RecName: Full=Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase;
EC 2.7.8.33;
AltName: Full=UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase;
AltName: Full=Undecaprenyl-phosphate GlcNAc-1-phosphate transferase;
Gene name
wecA

Comments [?]

Function Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55).
Catalytic activity RHEA:28090: di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP
EC 2.7.8.33
Cofactor Mg(2+)
Mn(2+)
Pathway Bacterial outer membrane biogenesis; LPS O-antigen biosynthesis.
case <OC:Enterobacterales>
Pathway Bacterial outer membrane biogenesis; enterobacterial common antigen biosynthesis.
end case
Subcellular location Cell inner membrane; Multi-pass membrane protein.
Similarity Belongs to the glycosyltransferase 4 family. WecA subfamily.

Keywords [?]

Cell inner membrane
Cell membrane
Glycosyltransferase
Lipopolysaccharide biosynthesis
Magnesium
Manganese
Membrane
Transferase
Transmembrane
Transmembrane helix

Gene Ontology [?]

GO:0036380; Molecular function: UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase activity.
case <OC:Enterobacterales>
GO:0009246; Biological process: enterobacterial common antigen biosynthetic process.
end case
GO:0009243; Biological process: O antigen biosynthetic process.
GO:0005887; Cellular component: integral component of plasma membrane.

Cross-references [?]

Pfam PF00953; Glycos_transf_4; 1;
TIGRFAMs TIGR02380; ECA_wecA; 1;

Computed features [?]

General Transmembrane; -; 10-11; trigger=yes;

Additional information [?]

Size range 320-390 amino acids
Related rules None
Fusion None


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