HAMAP rule MF_02030
General rule information
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Accession | MF_02030 |
Dates | 13-MAY-2015 (Created) 1-JUN-2023 (Last updated, Version 7) |
Name | WecA_Gammaproteo |
Scope | Bacteria; Gammaproteobacteria |
Template | P0AC78 (WECA_ECOLI) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55). |
Catalytic activity | RHEA:28090: di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP
EC 2.7.8.33 |
Cofactor | Mg(2+) |
Mn(2+) | |
Pathway | Bacterial outer membrane biogenesis; LPS O-antigen biosynthesis. |
case <OC:Enterobacterales>
Pathway | Bacterial outer membrane biogenesis; enterobacterial common antigen biosynthesis. |
end case
Subcellular location | Cell inner membrane; Multi-pass membrane protein. |
Similarity | Belongs to the glycosyltransferase 4 family. WecA subfamily. |
Keywords
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Cell inner membrane
Cell membrane
Glycosyltransferase
Lipopolysaccharide biosynthesis
Magnesium
Manganese
Membrane
Transferase
Transmembrane
Transmembrane helix
Cell membrane
Glycosyltransferase
Lipopolysaccharide biosynthesis
Magnesium
Manganese
Membrane
Transferase
Transmembrane
Transmembrane helix
Gene Ontology
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GO:0036380; Molecular function: UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase activity.
case <OC:Enterobacterales>
GO:0009246; Biological process: enterobacterial common antigen biosynthetic process.
end case
GO:0009243; Biological process: O antigen biosynthetic process.
GO:0005886; Cellular component: plasma membrane.
GO:0005886; Cellular component: plasma membrane.
Cross-references
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Computed features
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General | Transmembrane; -; 10-11; trigger=yes; |
Additional information
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Size range | 320-390 amino acids |
Related rules | None |
Fusion | None |