HAMAP rule MF_02030
General rule information
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| Accession | MF_02030 |
| Dates | 13-MAY-2015 (Created)
1-JUN-2023 (Last updated, Version 7) |
| Name | WecA_Gammaproteo |
| Scope(s) |
Bacteria Gammaproteobacteria |
| Template(s) | P0AC78 (WECA_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_02030 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | WECA |
| Protein name | RecName: Full=Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; EC=2.7.8.33; AltName: Full=UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase; AltName: Full=Undecaprenyl-phosphate GlcNAc-1-phosphate transferase; |
| Gene name | Name=wecA; |
Comments
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| FUNCTION | Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55). |
| CATALYTIC ACTIVITY | Reaction=di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha- D-glucosamine = N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis- undecaprenyl diphosphate + UMP; Xref=Rhea:RHEA:28090, ChEBI:CHEBI:57705, ChEBI:CHEBI:57865, ChEBI:CHEBI:60392, ChEBI:CHEBI:62959; EC=2.7.8.33; |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
| COFACTOR | Name=Mn(2+); Xref=ChEBI:CHEBI:29035; |
| PATHWAY | Bacterial outer membrane biogenesis; LPS O-antigen biosynthesis. |
| case <OC:Enterobacterales> | |
| PATHWAY | Bacterial outer membrane biogenesis; enterobacterial common antigen biosynthesis. |
| end case | |
| SUBCELLULAR LOCATION | Cell inner membrane; Multi-pass membrane protein. |
| SIMILARITY | Belongs to the glycosyltransferase 4 family. WecA subfamily. |
Keywords
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| Cell inner membrane |
| Cell membrane |
| Glycosyltransferase |
| Lipopolysaccharide biosynthesis |
| Magnesium |
| Manganese |
| Membrane |
| Transferase |
| Transmembrane |
| Transmembrane helix |
Gene Ontology
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| GO:0036380; Molecular function:UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase activity | |
| case <OCellular component:Enterobacterales> | |
| GO:0009246; Biological process:enterobacterial common antigen biosynthetic process | |
| end case | |
| GO:0009243; Biological process:O antigen biosynthetic process | |
| GO:0005886; Cellular component:plasma membrane | |
Cross-references
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| Pfam | PF00953; Glycos_transf_4; 1; |
| NCBIfam | TIGR02380; ECA_wecA; 1; |
| General | Transmembrane; -; 10-11; |
Features
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Additional information
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| Size range | 320-390 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |