HAMAP rule MF_02030

General rule information [?]

Accession	MF_02030
Dates	13-MAY-2015 (Created) 1-JUN-2023 (Last updated, Version 7)

Name	WecA_Gammaproteo

Scope

Bacteria; Gammaproteobacteria

Template

P0AC78 (WECA_ECOLI)

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

WECA

Protein name

RecName:		Full=Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase;
		EC 2.7.8.33;
AltName:		Full=UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase;
AltName:		Full=Undecaprenyl-phosphate GlcNAc-1-phosphate transferase;

Gene name

wecA

Comments [?]

Function	Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55).
Catalytic activity	RHEA:28090: di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP EC 2.7.8.33
Cofactor	Mg(2+)
	Mn(2+)
Pathway	Bacterial outer membrane biogenesis; LPS O-antigen biosynthesis.

case <OC:Enterobacterales>

Pathway

Bacterial outer membrane biogenesis; enterobacterial common antigen biosynthesis.

end case

Subcellular location	Cell inner membrane; Multi-pass membrane protein.
Similarity	Belongs to the glycosyltransferase 4 family. WecA subfamily.

Keywords [?]

Gene Ontology [?]

GO:0036380; Molecular function: UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase activity.

case <OC:Enterobacterales>

GO:0009246; Biological process: enterobacterial common antigen biosynthetic process.

end case

GO:0009243; Biological process: O antigen biosynthetic process.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam	PF00953; Glycos_transf_4; 1;
NCBIfam	TIGR02380; ECA_wecA; 1;

Computed features [?]

General

Transmembrane; -; 10-11; trigger=yes;

Additional information [?]