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HAMAP rule MF_02030

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General rule information [?]

Accession MF_02030
Dates 13-MAY-2015 (Created)
1-JUN-2023 (Last updated, Version 7)
Name WecA_Gammaproteo
Scope(s) Bacteria
Template(s) P0AC78 (WECA_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_02030 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier WECA
Protein name RecName: Full=Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase;
AltName: Full=UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase;
AltName: Full=Undecaprenyl-phosphate GlcNAc-1-phosphate transferase;
Gene name Name=wecA;

Comments [?]

FUNCTIONCatalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55).
CATALYTIC ACTIVITY Reaction=di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha- D-glucosamine = N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis- undecaprenyl diphosphate + UMP; Xref=Rhea:RHEA:28090, ChEBI:CHEBI:57705, ChEBI:CHEBI:57865, ChEBI:CHEBI:60392, ChEBI:CHEBI:62959; EC=;
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
COFACTOR Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
PATHWAYBacterial outer membrane biogenesis; LPS O-antigen biosynthesis.
case <OC:Enterobacterales>
PATHWAYBacterial outer membrane biogenesis; enterobacterial common antigen biosynthesis.
end case
SUBCELLULAR LOCATIONCell inner membrane; Multi-pass membrane protein.
SIMILARITYBelongs to the glycosyltransferase 4 family. WecA subfamily.

Keywords [?]

Gene Ontology [?]

GO:0036380; Molecular function:UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase activity
case <OCellular component:Enterobacterales>
GO:0009246; Biological process:enterobacterial common antigen biosynthetic process
end case
GO:0009243; Biological process:O antigen biosynthetic process
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam PF00953; Glycos_transf_4; 1;
NCBIfam TIGR02380; ECA_wecA; 1;
General Transmembrane; -; 10-11;

Features [?]

Additional information [?]

Size range 320-390 amino acids
Related rules None
Fusion Nter: None Cter: None

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