HAMAP rule MF_02036

General rule information [?]

Accession	MF_02036
Dates	1-JUL-2015 (Created) 3-SEP-2024 (Last updated, Version 8)
Name	EgtC
Scope(s)	Bacteria Actinomycetota
Template(s)	A0R5M9 (EGTC_MYCS2); [ Recover all ]
Triggered by	HAMAP; MF_02036 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	EGTC
Protein name	RecName: Full=Gamma-glutamyl-hercynylcysteine sulfoxide hydrolase; EC=3.5.1.118; AltName: Full=Gamma-glutamyl hercynylcysteine S-oxide hydrolase;
Gene name	Name=egtC;

Comments [?]

FUNCTION	Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine.
CATALYTIC ACTIVITY	Reaction=gamma-L-glutamyl-hercynylcysteine S-oxide + H2O = S-(hercyn-2- yl)-L-cysteine S-oxide + L-glutamate; Xref=Rhea:RHEA:42684, ChEBI:CHEBI:15377, ChEBI:CHEBI:29985, ChEBI:CHEBI:82703, ChEBI:CHEBI:82706; EC=3.5.1.118;
PATHWAY	Amino-acid biosynthesis; ergothioneine biosynthesis.

Keywords [?]

Gene Ontology [?]

GO:0016811; Molecular function:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

GO:0052699; Biological process:ergothioneine biosynthetic process

Cross-references [?]

PROSITE	PS51278; GATASE_TYPE_2; 1;
NCBIfam	TIGR03442; TIGR03442; 1;

Features [?]

Additional information [?]