HAMAP rule MF_02036

General rule information [?]

Accession	MF_02036
Dates	1-JUL-2015 (Created) 1-JUN-2023 (Last updated, Version 7)

Name

EgtC

Scope

Bacteria; Actinomycetota

Template

A0R5M9 (EGTC_MYCS2)

Triggered by

HAMAP; MF_02036 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

EGTC

Protein name

RecName:		Full=Gamma-glutamyl-hercynylcysteine sulfoxide hydrolase;
		EC 3.5.1.118;
AltName:		Full=Gamma-glutamyl hercynylcysteine S-oxide hydrolase;

Gene name

egtC

Comments [?]

Function	Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine.
Catalytic activity	RHEA:42684: gamma-L-glutamyl-hercynylcysteine S-oxide + H2O = L-glutamate + S-(hercyn-2-yl)-L-cysteine S-oxide EC 3.5.1.118
Pathway	Amino-acid biosynthesis; ergothioneine biosynthesis.

Keywords [?]

Glutamine amidotransferase
Hydrolase

Gene Ontology [?]

GO:0016811; Molecular function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides.
GO:0052699; Biological process: ergothioneine biosynthetic process.

Cross-references [?]

PROSITE	PS51278; GATASE_TYPE_2; 1; trigger=PRU00609;
NCBIfam	TIGR03442; TIGR03442; 1;

Additional information [?]

Size range	223-301 amino acids
Related rules	None
Fusion	None

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