HAMAP rule MF_02038
General rule information
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| Accession | MF_02038 |
| Dates | 1-JUL-2015 (Created)
1-JUN-2023 (Last updated, Version 5) |
| Name | EgtE |
| Scope(s) |
Bacteria Actinomycetota |
| Template(s) | A0R5M7 (EGTE_MYCS2); [ Recover all ] |
| Triggered by |
HAMAP; MF_02038 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | EGTE |
| Protein name | RecName: Full=Probable hercynylcysteine sulfoxide lyase; EC=4.4.-.-; |
| Gene name | Name=egtE; |
Comments
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| FUNCTION | Probably catalyzes the conversion of hercynylcysteine sulfoxide to ergothioneine. |
| CATALYTIC ACTIVITY | Reaction=AH2 + H(+) + S-(hercyn-2-yl)-L-cysteine S-oxide = A + ergothioneine + NH4(+) + pyruvate; Xref=Rhea:RHEA:42688, ChEBI:CHEBI:13193, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378, ChEBI:CHEBI:17499, ChEBI:CHEBI:28938, ChEBI:CHEBI:82706, ChEBI:CHEBI:134344; |
| COFACTOR | Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; |
| PATHWAY | Amino-acid biosynthesis; ergothioneine biosynthesis. |
| SIMILARITY | Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. EgtE subfamily. |
Keywords
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Gene Ontology
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| GO:0016846; Molecular function:carbon-sulfur lyase activity |
| GO:0052699; Biological process:ergothioneine biosynthetic process |
Cross-references
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Features
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| From: EGTE_MYCS2 (A0R5M7) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| MOD_RES | 203 | 203 | /note="N6-(pyridoxal phosphate)lysine" | K | ||||||||
Additional information
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| Size range | 359-425 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |