HAMAP rule MF_02051

General rule information [?]

Accession	MF_02051
Dates	7-JAN-2016 (Created) 5-MAY-2020 (Last updated, Version 5)

Name

LsrG

Scope

Bacteria; Enterobacterales

Template

P64461 (LSRG_ECOLI)

Triggered by

HAMAP; MF_02051 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

LSRG

Protein name

RecName:		Full=(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase;
		EC 5.3.1.32;
AltName:		Full=Autoinducer 2-degrading protein LsrG;
		Short=AI-2-degrading protein LsrG;
AltName:		Full=Phospho-(S)-4,5-dihydroxy-2,3-pentanedione isomerase;
AltName:		Full=Phospho-AI-2 isomerase;

Gene name

lsrG

Comments [?]

Function	Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the conversion of (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione (P-DPD) to 3-hydroxy-5-phosphonooxypentane-2,4-dione (P-HPD).
Catalytic activity	RHEA:44360: (2S)-2-hydroxy-3,4-dioxopentyl phosphate = 3-hydroxy-2,4-dioxopentyl phosphate EC 5.3.1.32
Subunit	Homodimer.
Subcellular location	Cytoplasm.
Similarity	Belongs to the LsrG family.

Keywords [?]

Cytoplasm
Isomerase

Gene Ontology [?]

GO:0016861; Molecular function: intramolecular oxidoreductase activity, interconverting aldoses and ketoses.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

PROSITE	PS51725; ABM; 1; trigger=PRU01062;
Pfam	PF03992; ABM; 1;

Additional information [?]

Size range	95-111 amino acids
Related rules	None
Fusion	None

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