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HAMAP rule MF_02065
General rule information
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| Accession | MF_02065 |
| Dates | 19-MAY-2016 (Created)
2-MAY-2024 (Last updated, Version 7) |
| Name | MltG |
| Scope(s) |
Bacteria |
| Template(s) | P28306 (MLTG_ECOLI); A0A0H2ZLQ1 (MLTG_STRP2); [ Recover all ] |
| Triggered by |
HAMAP; MF_02065 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | MLTG |
| Protein name | RecName: Full=Endolytic murein transglycosylase; EC=4.2.2.29; AltName: Full=Peptidoglycan lytic transglycosylase; AltName: Full=Peptidoglycan polymerization terminase; |
| Gene name | Name=mltG; |
Comments
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| FUNCTION | Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. |
| CATALYTIC ACTIVITY | Reaction=a peptidoglycan chain = a peptidoglycan chain with N-acetyl- 1,6-anhydromuramyl-[peptide] at the reducing end + a peptidoglycan chain with N-acetylglucosamine at the non-reducing end.; EC=4.2.2.29; |
| case ((defined <Property:Membrane> and <Property:Membrane=2>) or <OC:Pseudomonadota>) and <Feature:Transmembrane==1> | |
| SUBCELLULAR LOCATION | Cell inner membrane; Single-pass membrane protein. |
| else case <Feature:Transmembrane==1> | |
| SUBCELLULAR LOCATION | Cell membrane; Single-pass membrane protein. |
| end case | |
| SIMILARITY | Belongs to the transglycosylase MltG family. |
Keywords
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| case (defined <Property:Membrane> and <Property:Membrane=2>) or <OC:Pseudomonadota> | |
| Cell inner membrane | |
| end case | |
| Cell membrane | |
| Cell wall biogenesis/degradation | |
| Lyase | |
| Membrane | |
| Transmembrane | |
| Transmembrane helix | |
Gene Ontology
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| GO:0008932; Molecular function:lytic endotransglycosylase activity |
| GO:0009252; Biological process:peptidoglycan biosynthetic process |
| GO:0005886; Cellular component:plasma membrane |
Cross-references
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| Pfam | PF02618; YceG; 1; |
| NCBIfam | TIGR00247; TIGR00247; 1; |
| General | Transmembrane; -; 1; |
Features
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| From: MLTG_ECOLI (P28306) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| SITE | 218 | 218 | /note="Important for catalytic activity" | E | ||||||||
Additional information
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| Size range | 250-680 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | Rod-shaped bacteria contain a short N-terminal cytoplasmic domain (<20 aa) and ovoid bacteria contain a long N-terminal cytoplasmic domain (150-200 aa). (PubMed:26933838) |