HAMAP rule MF_02065
General rule information
[?]
Accession | MF_02065 |
Dates | 19-MAY-2016 (Created)
2-MAY-2024 (Last updated, Version 7) |
Name | MltG |
Scope(s) |
Bacteria |
Template(s) | P28306 (MLTG_ECOLI); A0A0H2ZLQ1 (MLTG_STRP2); [ Recover all ] |
Triggered by |
HAMAP; MF_02065 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Identifier | MLTG |
Protein name | RecName: Full=Endolytic murein transglycosylase; EC=4.2.2.29; AltName: Full=Peptidoglycan lytic transglycosylase; AltName: Full=Peptidoglycan polymerization terminase; |
Gene name | Name=mltG; |
Comments
[?]
FUNCTION | Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. |
CATALYTIC ACTIVITY | Reaction=a peptidoglycan chain = a peptidoglycan chain with N-acetyl- 1,6-anhydromuramyl-[peptide] at the reducing end + a peptidoglycan chain with N-acetylglucosamine at the non-reducing end.; EC=4.2.2.29; |
case ((defined <Property:Membrane> and <Property:Membrane=2>) or <OC:Pseudomonadota>) and <Feature:Transmembrane==1> | |
SUBCELLULAR LOCATION | Cell inner membrane; Single-pass membrane protein. |
else case <Feature:Transmembrane==1> | |
SUBCELLULAR LOCATION | Cell membrane; Single-pass membrane protein. |
end case | |
SIMILARITY | Belongs to the transglycosylase MltG family. |
Keywords
[?]
case (defined <Property:Membrane> and <Property:Membrane=2>) or <OC:Pseudomonadota> | |
Cell inner membrane | |
end case | |
Cell membrane | |
Cell wall biogenesis/degradation | |
Lyase | |
Membrane | |
Transmembrane | |
Transmembrane helix |
Gene Ontology
[?]
GO:0008932; Molecular function:lytic endotransglycosylase activity |
GO:0009252; Biological process:peptidoglycan biosynthetic process |
GO:0005886; Cellular component:plasma membrane |
Cross-references
[?]
Pfam | PF02618; YceG; 1; |
NCBIfam | TIGR00247; TIGR00247; 1; |
General | Transmembrane; -; 1; |
Features
[?]
From: MLTG_ECOLI (P28306) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
SITE | 218 | 218 | /note="Important for catalytic activity" | E |
Additional information
[?]
Size range | 250-680 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |
Comments | Rod-shaped bacteria contain a short N-terminal cytoplasmic domain (<20 aa) and ovoid bacteria contain a long N-terminal cytoplasmic domain (150-200 aa). (PubMed:26933838) |