HAMAP rule MF_02065

General rule information [?]

Accession	MF_02065
Dates	19-MAY-2016 (Created) 1-JUN-2023 (Last updated, Version 6)

Name

MltG

Scope

Bacteria

Templates

P28306 (MLTG_ECOLI); A0A0H2ZLQ1 (MLTG_STRP2): [Recover all]

Triggered by

HAMAP; MF_02065 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

MLTG

Protein name

RecName:		Full=Endolytic murein transglycosylase;
		EC 4.2.2.-;
AltName:		Full=Peptidoglycan polymerization terminase;

Gene name

mltG

Comments [?]

Function

Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

case ((defined <Property:Membrane> and <Property:Membrane=2>) or <OC:Pseudomonadota>) and <Feature:Transmembrane==1>

Subcellular location

Cell inner membrane; Single-pass membrane protein.

else case <Feature:Transmembrane==1>

Subcellular location

Cell membrane; Single-pass membrane protein.

end case

Similarity

Belongs to the transglycosylase MltG family.

Keywords [?]

case (defined <Property:Membrane> and <Property:Membrane=2>) or <OC:Pseudomonadota>

Cell inner membrane

end case

Cell membrane
Cell wall biogenesis/degradation
Lyase
Membrane
Transmembrane
Transmembrane helix

Gene Ontology [?]

GO:0008932; Molecular function: lytic endotransglycosylase activity.
GO:0009252; Biological process: peptidoglycan biosynthetic process.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam	PF02618; YceG; 1;
NCBIfam	TIGR00247; TIGR00247; 1;

Computed features [?]

General

Transmembrane; -; 1; trigger=yes;

Features [?]

From: MLTG_ECOLI (P28306)

Key From To Description Tag Condition FTGroup

SITE 218 218 Important for catalytic activity E

Additional information [?]

Size range	250-680 amino acids
Related rules	None
Fusion	None
Comments	Rod-shaped bacteria contain a short N-terminal cytoplasmic domain (<20 aa) and ovoid bacteria contain a long N-terminal cytoplasmic domain (150-200 aa). (PubMed:26933838)

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