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HAMAP rule MF_02065

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General rule information [?]

Accession MF_02065
Dates 19-MAY-2016 (Created)
1-JUN-2023 (Last updated, Version 6)
Name MltG
Scope(s) Bacteria
Template(s) P28306 (MLTG_ECOLI); A0A0H2ZLQ1 (MLTG_STRP2); [ Recover all ]
Triggered by HAMAP; MF_02065 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MLTG
Protein name RecName: Full=Endolytic murein transglycosylase;
AltName: Full=Peptidoglycan polymerization terminase;
Gene name Name=mltG;

Comments [?]

FUNCTIONFunctions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.
case ((defined <Property:Membrane> and <Property:Membrane=2>) or <OC:Pseudomonadota>) and <Feature:Transmembrane==1>
SUBCELLULAR LOCATIONCell inner membrane; Single-pass membrane protein.
else case <Feature:Transmembrane==1>
SUBCELLULAR LOCATIONCell membrane; Single-pass membrane protein.
end case
SIMILARITYBelongs to the transglycosylase MltG family.

Keywords [?]

case (defined <Property:Membrane> and <Property:Membrane=2>) or <OC:Pseudomonadota>
Cell inner membrane
end case
Cell membrane
Cell wall biogenesis/degradation
Transmembrane helix

Gene Ontology [?]

GO:0008932; Molecular function:lytic endotransglycosylase activity
GO:0009252; Biological process:peptidoglycan biosynthetic process
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam PF02618; YceG; 1;
NCBIfam TIGR00247; TIGR00247; 1;
General Transmembrane; -; 1;

Features [?]

From: MLTG_ECOLI (P28306)
Key From To Description Tag Condition FTGroup
SITE 218 218 /note="Important for catalytic activity" E

Additional information [?]

Size range 250-680 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments Rod-shaped bacteria contain a short N-terminal cytoplasmic domain (<20 aa) and ovoid bacteria contain a long N-terminal cytoplasmic domain (150-200 aa). (PubMed:26933838)

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