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HAMAP rule MF_02073

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General rule information [?]

Accession MF_02073
Dates 24-AUG-2016 (Created)
1-JUN-2023 (Last updated, Version 6)
Name Putrescine_transp
Scope(s) Bacteria
Template(s) P0AAF1 (POTE_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_02073 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier POTE
case <OC:Gammaproteobacteria>
Protein name RecName: Full=Putrescine transporter PotE;
AltName: Full=Putrescine-proton symporter / putrescine-ornithine antiporter;
Gene name Name=potE;
Protein name RecName: Full=Putrescine transporter;
end case

Comments [?]

case <OC:Gammaproteobacteria>
FUNCTIONCatalyzes both the uptake and excretion of putrescine. The uptake of putrescine is dependent on the membrane potential and the excretion involves putrescine-ornithine antiporter activity.
CATALYTIC ACTIVITY Reaction=H(+)(in) + putrescine(in) = H(+)(out) + putrescine(out); Xref=Rhea:RHEA:28891, ChEBI:CHEBI:15378, ChEBI:CHEBI:326268; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:28893;
CATALYTIC ACTIVITY Reaction=L-ornithine(out) + putrescine(in) = L-ornithine(in) + putrescine(out); Xref=Rhea:RHEA:28827, ChEBI:CHEBI:46911, ChEBI:CHEBI:326268; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:28828;
end case
case <OC:Pseudomonadota>
SUBCELLULAR LOCATIONCell inner membrane; Multi-pass membrane protein.
SUBCELLULAR LOCATIONCell membrane; Multi-pass membrane protein.
end case
SIMILARITYBelongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family.

Keywords [?]

case <OC:Pseudomonadota>
Cell inner membrane
end case
Cell membrane
Transmembrane helix
case <OC:Gammaproteobacteria>
Amino-acid transport
end case

Gene Ontology [?]

GO:0015489; Molecular function:putrescine transmembrane transporter activity
GO:0015847; Biological process:putrescine transport
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam PF13520; AA_permease_2; 1;
NCBIfam TIGR00905; 2A0302; 1;
NCBIfam TIGR04299; antiport_PotE; 1;
PIRSF PIRSF006060; AA_transporter; 1;
General Transmembrane; -; 12;

Features [?]

Additional information [?]

Size range 420-475 amino acids
Related rules None
Fusion Nter: None Cter: None

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