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Annotation rule MF_02079
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General rule information [?]

Accession MF_02079
Dates 23-NOV-2016 (Created)
4-NOV-2020 (Last updated, Version 6)
Name PGT_RodA
Scope
Bacteria
Templates P0ABG7 (RODA_ECOLI); P39604 (RODA_BACSU): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
RODA
case <OC:Proteobacteria>
Protein name
RecName: Full=Peptidoglycan glycosyltransferase MrdB;
Short=PGT;
EC 2.4.1.129;
AltName: Full=Cell elongation protein RodA;
AltName: Full=Cell wall polymerase;
AltName: Full=Peptidoglycan polymerase;
Short=PG polymerase;
Gene name
mrdB, rodA
else
Protein name
RecName: Full=Peptidoglycan glycosyltransferase RodA;
Short=PGT;
EC 2.4.1.129;
AltName: Full=Cell elongation protein RodA;
AltName: Full=Cell wall polymerase;
AltName: Full=Peptidoglycan polymerase;
Short=PG polymerase;
Gene name
rodA
end case

Comments [?]

Function Peptidoglycan polymerase that is essential for cell wall elongation.
Catalytic activity RHEA:23708: [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)
EC 2.4.1.129
Pathway Cell wall biogenesis; peptidoglycan biosynthesis.
case <OC:Proteobacteria> or (defined <Property:Membrane> and <Property:Membrane=2>)
Subcellular location Cell inner membrane; Multi-pass membrane protein.
else
Subcellular location Cell membrane; Multi-pass membrane protein.
end case
Similarity Belongs to the SEDS family. MrdB/RodA subfamily.

Keywords [?]

case <OC:Proteobacteria> or (defined <Property:Membrane> and <Property:Membrane=2>)
Cell inner membrane
end case
Cell membrane
Cell shape
Cell wall biogenesis/degradation
Glycosyltransferase
Membrane
Peptidoglycan synthesis
Transferase
Transmembrane
Transmembrane helix

Gene Ontology [?]

GO:0008955; Molecular function: peptidoglycan glycosyltransferase activity.
GO:0009252; Biological process: peptidoglycan biosynthetic process.
GO:0005887; Cellular component: integral component of plasma membrane.

Cross-references [?]

PROSITE PS00428; FTSW_RODA_SPOVE; 1;
Pfam PF01098; FTSW_RODA_SPOVE; 1;
TIGRFAMs TIGR02210; rodA_shape; 1;

Computed features [?]

General Transmembrane; -; 7-12; trigger=yes;

Additional information [?]

Size range 310-470 amino acids
Related rules None
Fusion None


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