HAMAP rule MF_02079

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_02079
Accession	MF_02079
Dates	23-NOV-2016 (Created) 7-NOV-2024 (Last updated, Version 12)
Name	PGT_RodA
Scope(s)	Bacteria
Template(s)	P0ABG7 (RODA_ECOLI); P39604 (RODA_BACSU); [ Recover all ]
Triggered by	HAMAP; MF_02079 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	RODA
case <OC:Pseudomonadota>
Protein name	RecName: Full=Peptidoglycan glycosyltransferase MrdB; Short=PGT; EC=2.4.99.28; AltName: Full=Cell elongation protein RodA; AltName: Full=Cell wall polymerase; AltName: Full=Peptidoglycan polymerase; Short=PG polymerase;
Gene name	Name=mrdB; Synonyms=rodA;
else
Protein name	RecName: Full=Peptidoglycan glycosyltransferase RodA; Short=PGT; EC=2.4.99.28; AltName: Full=Cell elongation protein RodA; AltName: Full=Cell wall polymerase; AltName: Full=Peptidoglycan polymerase; Short=PG polymerase;
Gene name	Name=rodA;
end case

Comments [?]

FUNCTION	Peptidoglycan polymerase that is essential for cell wall elongation.
CATALYTIC ACTIVITY	Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D- Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc- (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa- cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma- D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans,octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+); Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603, ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033, ChEBI:CHEBI:78435; EC=2.4.99.28;
PATHWAY	Cell wall biogenesis; peptidoglycan biosynthesis.
case <OC:Pseudomonadota> or (defined <Property:Membrane> and <Property:Membrane=2>)
SUBCELLULAR LOCATION	Cell inner membrane; Multi-pass membrane protein.
else
SUBCELLULAR LOCATION	Cell membrane; Multi-pass membrane protein.
end case
SIMILARITY	Belongs to the SEDS family. MrdB/RodA subfamily.

Keywords [?]

case <OC:Pseudomonadota> or (defined <Property:Membrane> and <Property:Membrane=2>)
Cell inner membrane
end case
Cell membrane
Cell shape
Cell wall biogenesis/degradation
Glycosyltransferase
Membrane
Peptidoglycan synthesis
Transferase
Transmembrane
Transmembrane helix

Gene Ontology [?]

GO:0008955; Molecular function:peptidoglycan glycosyltransferase activity

GO:0009252; Biological process:peptidoglycan biosynthetic process

GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Features [?]

Additional information [?]