HAMAP rule MF_02086

General rule information [?]

Accession	MF_02086
Dates	14-MAR-2017 (Created) 19-NOV-2022 (Last updated, Version 6)

Name	PdxA_Epsilonprot

Scope

Bacteria; Epsilonproteobacteria

Templates

Q9PN58 (PDXA_CAMJE); P19624 (PDXA_ECOLI): [Recover all]

Triggered by

HAMAP; MF_02086 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

PDXA

Protein name

RecName:		Full=4-hydroxythreonine-4-phosphate dehydrogenase;
		EC 1.1.1.262;
AltName:		Full=4-(phosphohydroxy)-L-threonine dehydrogenase;

Gene name

pdxA

Comments [?]

Function	Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
Catalytic activity	RHEA:32275: 4-(phosphooxy)-L-threonine + NAD(+) = 3-amino-2-oxopropyl phosphate + CO2 + NADH EC 1.1.1.262
Cofactor	Zn(2+) Mg(2+) Co(2+)
Pathway	Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 4/5.
Subunit	Homodimer.
Subcellular location	Cytoplasm.
Miscellaneous	The active site is located at the dimer interface.
Similarity	Belongs to the PdxA family.

Keywords [?]

Cobalt
Cytoplasm
Magnesium
Metal-binding
NAD
NADP
Oxidoreductase
Pyridoxine biosynthesis
Zinc

Gene Ontology [?]

GO:0050570; Molecular function: 4-hydroxythreonine-4-phosphate dehydrogenase activity.
GO:0046872; Molecular function: metal ion binding.
GO:0050897; Molecular function: cobalt ion binding.
GO:0008270; Molecular function: zinc ion binding.
GO:0000287; Molecular function: magnesium ion binding.
GO:0042823; Biological process: pyridoxal phosphate biosynthetic process.
GO:0008615; Biological process: pyridoxine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam	PF04166; PdxA; 1;
TIGRFAMs	TIGR00557; pdxA; 1;

Features [?]

From: PDXA_CAMJE (Q9PN58)

Key From To Description Tag Condition FTGroup

BINDING 177 177 /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" /ligand_note="ligand shared between dimeric partners H

BINDING 216 216 /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" /ligand_note="ligand shared between dimeric partners H

BINDING 301 301 /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" /ligand_note="ligand shared between dimeric partners H

BINDING (Optional) 148 148 /ligand="substrate H

BINDING (Optional) 149 149 /ligand="substrate T

BINDING (Optional) 309 309 /ligand="substrate K

BINDING (Optional) 318 318 /ligand="substrate N

BINDING (Optional) 327 327 /ligand="substrate R

Additional information [?]

Size range	296-375 amino acids
Related rules	None
Fusion	None

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