HAMAP rule MF_02086
General rule information
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Accession | MF_02086 |
Dates | 14-MAR-2017 (Created) 1-JUN-2023 (Last updated, Version 7) |
Name | PdxA_Epsilonprot |
Scope | Bacteria; Epsilonproteobacteria |
Templates | Q9PN58 (PDXA_CAMJE); P19624 (PDXA_ECOLI): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). |
Catalytic activity | RHEA:32275: 4-(phosphooxy)-L-threonine + NAD(+) = 3-amino-2-oxopropyl phosphate + CO2 + NADH
EC 1.1.1.262 |
Cofactor | Zn(2+) Mg(2+) Co(2+) |
Pathway | Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 4/5. |
Subunit | Homodimer. |
Subcellular location | Cytoplasm. |
Miscellaneous | The active site is located at the dimer interface. |
Similarity | Belongs to the PdxA family. |
Keywords
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Gene Ontology
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GO:0050570; Molecular function: 4-hydroxythreonine-4-phosphate dehydrogenase activity.
GO:0046872; Molecular function: metal ion binding.
GO:0050897; Molecular function: cobalt ion binding.
GO:0008270; Molecular function: zinc ion binding.
GO:0000287; Molecular function: magnesium ion binding.
GO:0042823; Biological process: pyridoxal phosphate biosynthetic process.
GO:0008615; Biological process: pyridoxine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
GO:0046872; Molecular function: metal ion binding.
GO:0050897; Molecular function: cobalt ion binding.
GO:0008270; Molecular function: zinc ion binding.
GO:0000287; Molecular function: magnesium ion binding.
GO:0042823; Biological process: pyridoxal phosphate biosynthetic process.
GO:0008615; Biological process: pyridoxine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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Features
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From: PDXA_CAMJE (Q9PN58) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 177 | 177 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" /ligand_note="ligand shared between dimeric partners | H | ||||||||
BINDING | 216 | 216 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" /ligand_note="ligand shared between dimeric partners | H | ||||||||
BINDING | 301 | 301 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" /ligand_note="ligand shared between dimeric partners | H | ||||||||
BINDING (Optional) | 148 | 148 | /ligand="substrate | H | ||||||||
BINDING (Optional) | 149 | 149 | /ligand="substrate | T | ||||||||
BINDING (Optional) | 309 | 309 | /ligand="substrate | K | ||||||||
BINDING (Optional) | 318 | 318 | /ligand="substrate | N | ||||||||
BINDING (Optional) | 327 | 327 | /ligand="substrate | R |
Additional information
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Size range | 296-375 amino acids |
Related rules | None |
Fusion | None |