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HAMAP rule MF_02096

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General rule information [?]

Accession MF_02096
Dates 23-OCT-2017 (Created)
20-NOV-2019 (Last updated, Version 2)
Name Nre
Templates D4GTA5 (NREA_HALVD); A0A1B2LS07 (NREA_ARCFU); O28682 (NREB_ARCFU): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=DNA repair protein;

Comments [?]

Function Involved in DNA damage repair.
case <FTTag:PIP>
Subunit Interacts with the DNA polymerase sliding clamp (PCNA) via the PIP (PCNA-interacting peptide) motif.
end case
case <FTTag:zinc>
Domain Contains a predicted C4 metal binding domain at the N-terminus, which could be a zinc finger DNA binding domain.
end case
Similarity Belongs to the Nre family.

Keywords [?]

case <FTTag:zinc>
end case

Gene Ontology [?]

GO:0006281; Biological process: DNA repair.
case <FTTag:zinc>
GO:0008270; Molecular function: zinc ion binding.
end case

Cross-references [?]

Pfam PF04895; Nre_C; 1;
PF04894; Nre_N; 1;

Features [?]

From: NREB_ARCFU (O28682)
Key     From     To       Description   Tag   Condition   FTGroup
ZN_FING (Optional)     3     17       C4-type   zinc   C-x(2)-C-x(5,6)-C-x(2,4)-C  
MOTIF (Optional)     384     391       PIP motif   PIP   Q-x-x-[LIM]-x-x-[FYW]-[FYWVMLI]  

Additional information [?]

Size range 350-470 amino acids
Related rules None
Fusion None
Comments Almost all sequenced archaeal genomes encode at least one Nre protein (designated NreA) with a C-terminal PIP motif, but some species also encode a second protein (NreB) with a less clear-cut PIP.