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HAMAP rule MF_02096

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General rule information [?]

Accession MF_02096
Dates 23-OCT-2017 (Created)
20-NOV-2019 (Last updated, Version 2)
Name Nre
Scope(s) Archaea
Template(s) D4GTA5 (NREA_HALVD); A0A1B2LS07 (NREA_ARCFU); O28682 (NREB_ARCFU); [ Recover all ]
Triggered by HAMAP; MF_02096 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier NRE
Protein name RecName: Full=DNA repair protein;

Comments [?]

FUNCTIONInvolved in DNA damage repair.
case <FTTag:PIP>
SUBUNITInteracts with the DNA polymerase sliding clamp (PCNA) via the PIP (PCNA-interacting peptide) motif.
end case
case <FTTag:zinc>
DOMAINContains a predicted C4 metal binding domain at the N-terminus, which could be a zinc finger DNA binding domain.
end case
SIMILARITYBelongs to the Nre family.

Keywords [?]

DNA damage
DNA repair
case <FTTag:zinc>
end case

Gene Ontology [?]

GO:0006281; Biological process:DNA repair
case <FTTag:zinc>
GO:0008270; Molecular function:zinc ion binding
end case

Cross-references [?]

Pfam PF04895; Nre_C; 1;
Pfam PF04894; Nre_N; 1;

Features [?]

From: NREB_ARCFU (O28682)
Key From To Description Tag Condition FTGroup
ZN_FING 3 17 /note="C4-type" zinc C-x(2)-C-x(5,6)-C-x(2,4)-C
MOTIF 384 391 /note="PIP motif" PIP Q-x-x-[LIM]-x-x-[FYW]-[FYWVMLI]

Additional information [?]

Size range 350-470 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments Almost all sequenced archaeal genomes encode at least one Nre protein (designated NreA) with a C-terminal PIP motif, but some species also encode a second protein (NreB) with a less clear-cut PIP.

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