HAMAP rule MF_02096
General rule information
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| Accession | MF_02096 |
| Dates | 23-OCT-2017 (Created) 20-NOV-2019 (Last updated, Version 2) |
| Name | Nre |
| Scope | Archaea |
| Templates | D4GTA5 (NREA_HALVD); A0A1B2LS07 (NREA_ARCFU); O28682 (NREB_ARCFU): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
|
| Protein name |
|
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Comments
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| Function | Involved in DNA damage repair. |
case <FTTag:PIP>
| Subunit | Interacts with the DNA polymerase sliding clamp (PCNA) via the PIP (PCNA-interacting peptide) motif. |
end case
case <FTTag:zinc>
| Domain | Contains a predicted C4 metal binding domain at the N-terminus, which could be a zinc finger DNA binding domain. |
end case
| Similarity | Belongs to the Nre family. |
Keywords
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case <FTTag:zinc>
end case
Gene Ontology
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GO:0006281; Biological process: DNA repair.
case <FTTag:zinc>
GO:0008270; Molecular function: zinc ion binding.
end case
Cross-references
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Features
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| From: NREB_ARCFU (O28682) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ZN_FING (Optional) | 3 | 17 | C4-type | zinc | C-x(2)-C-x(5,6)-C-x(2,4)-C | |||||||
| MOTIF (Optional) | 384 | 391 | PIP motif | PIP | Q-x-x-[LIM]-x-x-[FYW]-[FYWVMLI] | |||||||
Additional information
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| Size range | 350-470 amino acids |
| Related rules | None |
| Fusion | None |
| Comments | Almost all sequenced archaeal genomes encode at least one Nre protein (designated NreA) with a C-terminal PIP motif, but some species also encode a second protein (NreB) with a less clear-cut PIP. |