HAMAP rule MF_02096
General rule information
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| Accession | MF_02096 |
| Dates | 23-OCT-2017 (Created)
20-NOV-2019 (Last updated, Version 2) |
| Name | Nre |
| Scope(s) |
Archaea |
| Template(s) | D4GTA5 (NREA_HALVD); A0A1B2LS07 (NREA_ARCFU); O28682 (NREB_ARCFU); [ Recover all ] |
| Triggered by |
HAMAP; MF_02096 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | NRE |
| Protein name | RecName: Full=DNA repair protein; |
Comments
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| FUNCTION | Involved in DNA damage repair. |
| case <FTTag:PIP> | |
| SUBUNIT | Interacts with the DNA polymerase sliding clamp (PCNA) via the PIP (PCNA-interacting peptide) motif. |
| end case | |
| case <FTTag:zinc> | |
| DOMAIN | Contains a predicted C4 metal binding domain at the N-terminus, which could be a zinc finger DNA binding domain. |
| end case | |
| SIMILARITY | Belongs to the Nre family. |
Keywords
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| DNA damage | |
| DNA repair | |
| case <FTTag:zinc> | |
| Metal-binding | |
| Zinc | |
| Zinc-finger | |
| end case | |
Gene Ontology
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| GO:0006281; Biological process:DNA repair | |
| case <FTTag:zinc> | |
| GO:0008270; Molecular function:zinc ion binding | |
| end case | |
Cross-references
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Features
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| From: NREB_ARCFU (O28682) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ZN_FING | 3 | 17 | /note="C4-type" | zinc | C-x(2)-C-x(5,6)-C-x(2,4)-C | |||||||
| MOTIF | 384 | 391 | /note="PIP motif" | PIP | Q-x-x-[LIM]-x-x-[FYW]-[FYWVMLI] | |||||||
Additional information
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| Size range | 350-470 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | Almost all sequenced archaeal genomes encode at least one Nre protein (designated NreA) with a C-terminal PIP motif, but some species also encode a second protein (NreB) with a less clear-cut PIP. |