HAMAP rule MF_02098

General rule information [?]

Accession	MF_02098
Dates	31-OCT-2017 (Created) 26-JAN-2023 (Last updated, Version 8)

Name	Carnitine_monoox_B

Scope

Bacteria; Pseudomonadota

Templates

D0C9N8 (CNTB_ACIB2); F0KFI7 (CNTB_ACICP); P76254 (CNTB_ECOLI): [Recover all]

Triggered by

HAMAP; MF_02098 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

CNTB

Protein name

RecName:		Full=Carnitine monooxygenase reductase subunit;
		EC 1.14.13.239;
AltName:		Full=Carnitine monooxygenase beta subunit;

Comments [?]

Function	Converts carnitine to trimethylamine and malic semialdehyde.
Catalytic activity	RHEA:55396: (R)-carnitine + H(+) + NADH + O2 = (3R)-3-hydroxy-4-oxobutanoate + H2O + NAD(+) + trimethylamine EC 1.14.13.239
	RHEA:55368: (R)-carnitine + H(+) + NADPH + O2 = (3R)-3-hydroxy-4-oxobutanoate + H2O + NADP(+) + trimethylamine EC 1.14.13.239
Cofactor	FMN

case <FTGroup:1>

Cofactor

[2Fe-2S] cluster
Note: Binds 1 2Fe-2S cluster

end case

Pathway	Amine and polyamine metabolism; carnitine metabolism.
Subunit	Composed of an oxygenase subunit and a reductase subunit.
Similarity	Belongs to the PDR/VanB family. CntB subfamily.

Keywords [?]

case <FTGroup:1>

2Fe-2S
Iron-sulfur
Iron
Metal-binding

end case

Flavoprotein
FMN
NAD
NADP
Oxidoreductase

Gene Ontology [?]

GO:0016709; Molecular function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen.

case <FTGroup:1>

GO:0051537; Molecular function: 2 iron, 2 sulfur cluster binding.

end case

Cross-references [?]

PROSITE	PS00197; 2FE2S_FER_1; 1;
	PS51085; 2FE2S_FER_2; 1;
	PS51384; FAD_FR; 1; trigger=PRU00716;
Pfam	PF00970; FAD_binding_6; 1;
	PF00111; Fer2; 1;
	PF00175; NAD_binding_1; 1;
PRINTS	PR00409; PHDIOXRDTASE; 1;

Features [?]

From: CNTB_ACIB2 (D0C9N8)

Key From To Description Tag Condition FTGroup

BINDING 267 267 /ligand="[2Fe-2S] cluster" /ligand_id="ChEBI:CHEBI:190135 C 1

BINDING 272 272 /ligand="[2Fe-2S] cluster" /ligand_id="ChEBI:CHEBI:190135 C 1

BINDING 275 275 /ligand="[2Fe-2S] cluster" /ligand_id="ChEBI:CHEBI:190135 C 1

BINDING 305 305 /ligand="[2Fe-2S] cluster" /ligand_id="ChEBI:CHEBI:190135 C 1

Additional information [?]

Size range	285-330 amino acids
Related rules	None
Fusion	None
Comments	See MF_02097 for the oxygenase subunit.

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