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HAMAP rule MF_02098

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General rule information [?]

Accession MF_02098
Dates 31-OCT-2017 (Created)
26-JAN-2023 (Last updated, Version 8)
Name Carnitine_monoox_B
Scope(s) Bacteria
Template(s) D0C9N8 (CNTB_ACIB2); F0KFI7 (CNTB_ACICP); P76254 (CNTB_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_02098 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier CNTB
Protein name RecName: Full=Carnitine monooxygenase reductase subunit;
AltName: Full=Carnitine monooxygenase beta subunit;

Comments [?]

FUNCTIONConverts carnitine to trimethylamine and malic semialdehyde.
CATALYTIC ACTIVITY Reaction=(R)-carnitine + H(+) + NADH + O2 = (3R)-3-hydroxy-4- oxobutanoate + H2O + NAD(+) + trimethylamine; Xref=Rhea:RHEA:55396, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16347, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:58389, ChEBI:CHEBI:138809; EC=;
CATALYTIC ACTIVITY Reaction=(R)-carnitine + H(+) + NADPH + O2 = (3R)-3-hydroxy-4- oxobutanoate + H2O + NADP(+) + trimethylamine; Xref=Rhea:RHEA:55368, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16347, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:58389, ChEBI:CHEBI:138809; EC=;
case <FTGroup:1>
COFACTOR Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135; Note=Binds 1 2Fe-2S cluster
end case
PATHWAYAmine and polyamine metabolism; carnitine metabolism.
SUBUNITComposed of an oxygenase subunit and a reductase subunit.
SIMILARITYBelongs to the PDR/VanB family. CntB subfamily.

Keywords [?]

Gene Ontology [?]

GO:0016709; Molecular function:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
case <FTGroup:1>
GO:0051537; Molecular function:2 iron, 2 sulfur cluster binding
end case

Cross-references [?]

PROSITE PS00197; 2FE2S_FER_1; 1;
PROSITE PS51085; 2FE2S_FER_2; 1;
Pfam PF00970; FAD_binding_6; 1;
Pfam PF00111; Fer2; 1;
Pfam PF00175; NAD_binding_1; 1;

Features [?]

From: CNTB_ACIB2 (D0C9N8)
Key From To Description Tag Condition FTGroup
BINDING 267 267 /ligand="[2Fe-2S] cluster"
C 1
BINDING 272 272 /ligand="[2Fe-2S] cluster"
C 1
BINDING 275 275 /ligand="[2Fe-2S] cluster"
C 1
BINDING 305 305 /ligand="[2Fe-2S] cluster"
C 1

Additional information [?]

Size range 285-330 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments See MF_02097 for the oxygenase subunit.

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