HAMAP rule MF_02098
General rule information
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Accession | MF_02098 |
Dates | 31-OCT-2017 (Created) 26-JAN-2023 (Last updated, Version 8) |
Name | Carnitine_monoox_B |
Scope | Bacteria; Pseudomonadota |
Templates | D0C9N8 (CNTB_ACIB2); F0KFI7 (CNTB_ACICP); P76254 (CNTB_ECOLI): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
|
Comments
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Function | Converts carnitine to trimethylamine and malic semialdehyde. |
Catalytic activity | RHEA:55396: (R)-carnitine + H(+) + NADH + O2 = (3R)-3-hydroxy-4-oxobutanoate + H2O + NAD(+) + trimethylamine
EC 1.14.13.239 |
RHEA:55368: (R)-carnitine + H(+) + NADPH + O2 = (3R)-3-hydroxy-4-oxobutanoate + H2O + NADP(+) + trimethylamine
EC 1.14.13.239 |
|
Cofactor | FMN |
case <FTGroup:1>
Cofactor | [2Fe-2S] cluster Note: Binds 1 2Fe-2S cluster |
end case
Pathway | Amine and polyamine metabolism; carnitine metabolism. |
Subunit | Composed of an oxygenase subunit and a reductase subunit. |
Similarity | Belongs to the PDR/VanB family. CntB subfamily. |
Keywords
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case <FTGroup:1>
end case
Gene Ontology
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GO:0016709; Molecular function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen.
case <FTGroup:1>
GO:0051537; Molecular function: 2 iron, 2 sulfur cluster binding.
end case
Cross-references
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PROSITE | PS00197; 2FE2S_FER_1; 1; |
PS51085; 2FE2S_FER_2; 1; | |
PS51384; FAD_FR; 1; trigger=PRU00716; | |
Pfam | PF00970; FAD_binding_6; 1; |
PF00111; Fer2; 1; | |
PF00175; NAD_binding_1; 1; | |
PRINTS | PR00409; PHDIOXRDTASE; 1; |
Features
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From: CNTB_ACIB2 (D0C9N8) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 267 | 267 | /ligand="[2Fe-2S] cluster" /ligand_id="ChEBI:CHEBI:190135 | C | 1 | |||||||
BINDING | 272 | 272 | /ligand="[2Fe-2S] cluster" /ligand_id="ChEBI:CHEBI:190135 | C | 1 | |||||||
BINDING | 275 | 275 | /ligand="[2Fe-2S] cluster" /ligand_id="ChEBI:CHEBI:190135 | C | 1 | |||||||
BINDING | 305 | 305 | /ligand="[2Fe-2S] cluster" /ligand_id="ChEBI:CHEBI:190135 | C | 1 |
Additional information
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Size range | 285-330 amino acids |
Related rules | None |
Fusion | None |
Comments | See MF_02097 for the oxygenase subunit. |