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HAMAP rule MF_02098

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General rule information [?]

Accession MF_02098
Dates 31-OCT-2017 (Created)
26-JAN-2023 (Last updated, Version 8)
Name Carnitine_monoox_B
Bacteria; Pseudomonadota
Templates D0C9N8 (CNTB_ACIB2); F0KFI7 (CNTB_ACICP); P76254 (CNTB_ECOLI): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Carnitine monooxygenase reductase subunit;
AltName: Full=Carnitine monooxygenase beta subunit;

Comments [?]

Function Converts carnitine to trimethylamine and malic semialdehyde.
Catalytic activity RHEA:55396: (R)-carnitine + H(+) + NADH + O2 = (3R)-3-hydroxy-4-oxobutanoate + H2O + NAD(+) + trimethylamine
RHEA:55368: (R)-carnitine + H(+) + NADPH + O2 = (3R)-3-hydroxy-4-oxobutanoate + H2O + NADP(+) + trimethylamine
Cofactor FMN
case <FTGroup:1>
Cofactor [2Fe-2S] cluster
Note: Binds 1 2Fe-2S cluster
end case
Pathway Amine and polyamine metabolism; carnitine metabolism.
Subunit Composed of an oxygenase subunit and a reductase subunit.
Similarity Belongs to the PDR/VanB family. CntB subfamily.

Keywords [?]

case <FTGroup:1>
end case

Gene Ontology [?]

GO:0016709; Molecular function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen.
case <FTGroup:1>
GO:0051537; Molecular function: 2 iron, 2 sulfur cluster binding.
end case

Cross-references [?]

PROSITE PS00197; 2FE2S_FER_1; 1;
PS51085; 2FE2S_FER_2; 1;
PS51384; FAD_FR; 1; trigger=PRU00716;
Pfam PF00970; FAD_binding_6; 1;
PF00111; Fer2; 1;
PF00175; NAD_binding_1; 1;

Features [?]

From: CNTB_ACIB2 (D0C9N8)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     267     267       /ligand="[2Fe-2S] cluster" /ligand_id="ChEBI:CHEBI:190135     C   1
BINDING     272     272       /ligand="[2Fe-2S] cluster" /ligand_id="ChEBI:CHEBI:190135     C   1
BINDING     275     275       /ligand="[2Fe-2S] cluster" /ligand_id="ChEBI:CHEBI:190135     C   1
BINDING     305     305       /ligand="[2Fe-2S] cluster" /ligand_id="ChEBI:CHEBI:190135     C   1

Additional information [?]

Size range 285-330 amino acids
Related rules None
Fusion None
Comments See MF_02097 for the oxygenase subunit.