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HAMAP rule MF_02101

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General rule information [?]

Accession MF_02101
Dates 15-MAY-2009 (Created)
17-FEB-2023 (Last updated, Version 12)
Name DHNA_CoA_hydrolase
Scope(s) Bacteria
Template(s) Q55777 (DNCH_SYNY3); [ Recover all ]
Triggered by HAMAP; MF_02101 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier DNCH
Protein name RecName: Full=1,4-dihydroxy-2-naphthoyl-CoA hydrolase;
                 Short=DHNA-CoA hydrolase;
AltName: Full=DHNA-CoA thioesterase;

Comments [?]

FUNCTIONCatalyzes the hydrolysis of 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA), a reaction involved in phylloquinone (vitamin K1) biosynthesis.
CATALYTIC ACTIVITY Reaction=1,4-dihydroxy-2-naphthoyl-CoA + H2O = 1,4-dihydroxy-2- naphthoate + CoA + H(+); Xref=Rhea:RHEA:26309, ChEBI:CHEBI:11173, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:58897; EC=;
PATHWAYQuinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 7/7.
PATHWAYCofactor biosynthesis; phylloquinone biosynthesis.
SIMILARITYBelongs to the 4-hydroxybenzoyl-CoA thioesterase family. DHNA-CoA hydrolase subfamily.

Keywords [?]

Gene Ontology [?]

GO:0016790; Molecular function:thiolester hydrolase activity
GO:0042372; Biological process:phylloquinone biosynthetic process

Cross-references [?]

Pfam PF03061; 4HBT; 1;

Features [?]

From: DNCH_SYNY3 (Q55777)
Key From To Description Tag Condition FTGroup
ACT_SITE 16 16 D

Additional information [?]

Size range 131-160 amino acids
Related rules None
Fusion Nter: None Cter: None

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