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Annotation rule MF_02104
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General rule information [?]

Accession MF_02104
Dates 12-AUG-2009 (Created)
20-NOV-2019 (Last updated, Version 8)
Name LutC
Scope
Bacteria; Firmicutes
Templates O32259 (LUTC_BACSU); Q81GA3 (LUTC_BACCR): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
LUTC
Protein name
RecName: Full=Lactate utilization protein C;
Gene name
lutC

Comments [?]

Function Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source.
Similarity Belongs to the LutC/YkgG family.

Gene Ontology [?]

GO:0006089; Biological process: lactate metabolic process.

Cross-references [?]

Pfam PF02589; DUF162; 1;

Additional information [?]

Size range 220-241 amino acids
Related rules None
Fusion None
Comments The E.coli ykgEFG operon is a clear homolog of the B.subtilis lutABC operon, however it is not able of restoring L-lactate utilization to the B.subtilis mutant for lutABC operon (PubMed=19201793). Thus, ykgEFG operon may contribute to lactate catabolism in E.coli, but under conditions other than those tested, or alternatively, the ykgEFG operon may be responsible for the catabolism of a metabolite other than (but perhaps related to) lactate in E.coli. That's why the profile was not extended to Proteobacteria and this family rule is currently restricted to Firmicutes (in fact seed alignment only contains Bacillales), waiting for characterization in E.coli.