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| Annotation rule MF_02104 |
General rule information
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| Accession | MF_02104 |
| Dates | 12-AUG-2009 (Created) 13-JAN-2023 (Last updated, Version 9) |
| Name | LutC |
| Scope | Bacteria; Bacillota |
| Templates | O32259 (LUTC_BACSU); Q81GA3 (LUTC_BACCR): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source. |
| Similarity | Belongs to the LutC/YkgG family. |
Gene Ontology
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GO:0006089; Biological process: lactate metabolic process.
Cross-references
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| Pfam | PF02589; DUF162; 1; |
Additional information
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| Size range | 220-241 amino acids |
| Related rules | None |
| Fusion | None |
| Comments | The E.coli ykgEFG operon is a clear homolog of the B.subtilis lutABC operon, however it is not able of restoring L-lactate utilization to the B.subtilis mutant for lutABC operon (PubMed=19201793). Thus, ykgEFG operon may contribute to lactate catabolism in E.coli, but under conditions other than those tested, or alternatively, the ykgEFG operon may be responsible for the catabolism of a metabolite other than (but perhaps related to) lactate in E.coli. That's why the profile was not extended to Proteobacteria and this family rule is currently restricted to Bacillota (in fact seed alignment only contains Bacillales), waiting for characterization in E.coli. |