HAMAP logo

HAMAP rule MF_02105

Send feedback

General rule information [?]

Accession MF_02105
Dates 12-AUG-2009 (Created)
26-JAN-2023 (Last updated, Version 10)
Name LutA
Scope(s) Bacteria
Bacillota
Template(s) O07020 (LUTA_BACSU); Q81GA5 (LUTA_BACCR); [ Recover all ]
Triggered by HAMAP; MF_02105 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier LUTA
Protein name RecName: Full=Lactate utilization protein A;
Gene name Name=lutA;

Comments [?]

FUNCTIONIs involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source.
SIMILARITYBelongs to the LutA/YkgE family.

Keywords [?]


Gene Ontology [?]

GO:0006089; Biological process:lactate metabolic process

Cross-references [?]

Pfam PF02754; CCG; 2;

Features [?]


Additional information [?]

Size range 228-245 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments The E.coli ykgEFG operon is a clear homolog of the B.subtilis lutABC operon, however it is not able of restoring L-lactate utilization to the B.subtilis mutant for lutABC operon (PubMed=19201793). Thus, ykgEFG operon may contribute to lactate catabolism in E.coli, but under conditions other than those tested, or alternatively, the ykgEFG operon may be responsible for the catabolism of a metabolite other than (but perhaps related to) lactate in E.coli. That's why the profile was not extended to Pseudomonadota and this family rule is currently restricted to Bacillota (in fact seed alignment only contains Bacillales), waiting for characterization in E.coli.



View rule in raw text format (no links)