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HAMAP rule MF_02108

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General rule information [?]

Accession MF_02108
Dates 5-OCT-2009 (Created)
29-JUN-2022 (Last updated, Version 14)
Name HTH_type_MurR
Scope(s) Bacteria
Template(s) P77245 (MURR_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_02108 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MURR
Protein name RecName: Full=HTH-type transcriptional regulator MurR;
AltName: Full=MurPQ operon repressor;
Gene name Name=murR;

Comments [?]

FUNCTIONRepresses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6- phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator.
PATHWAYAmino-sugar metabolism; N-acetylmuramate degradation [regulation].

Keywords [?]

Gene Ontology [?]

GO:0003700; Molecular function:DNA-binding transcription factor activity
GO:0043470; Biological process:regulation of carbohydrate catabolic process
GO:0045892; Biological process:negative regulation of DNA-templated transcription

Cross-references [?]

PROSITE PS51464; SIS; 1;
Pfam PF01418; HTH_6; 1;
Pfam PF01380; SIS; 1;

Features [?]

Additional information [?]

Size range 266-287 amino acids
Related rules None
Fusion Nter: None Cter: None

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