HAMAP rule MF_02108

General rule information [?]

Accession	MF_02108
Dates	5-OCT-2009 (Created) 29-JUN-2022 (Last updated, Version 14)

Name	HTH_type_MurR

Scope

Bacteria; Enterobacterales

Template

P77245 (MURR_ECOLI)

Triggered by

HAMAP; MF_02108 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

MURR

Protein name

RecName:		Full=HTH-type transcriptional regulator MurR;
AltName:		Full=MurPQ operon repressor;

Gene name

murR

Comments [?]

Function	Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator.
Pathway	Amino-sugar metabolism; N-acetylmuramate degradation [regulation].
Subunit	Homotetramer.

Keywords [?]

Carbohydrate metabolism
DNA-binding
Repressor
Transcription
Transcription regulation

Gene Ontology [?]

GO:0003700; Molecular function: DNA-binding transcription factor activity.
GO:0043470; Biological process: regulation of carbohydrate catabolic process.
GO:0045892; Biological process: negative regulation of DNA-templated transcription.

Cross-references [?]

PROSITE	PS51071; HTH_RPIR; 1; trigger=PRU00390;
	PS51464; SIS; 1; trigger=PRU00797;
Pfam	PF01418; HTH_6; 1;
	PF01380; SIS; 1;

Additional information [?]

Size range	266-287 amino acids
Related rules	None
Fusion	None

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