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HAMAP rule MF_02108

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General rule information [?]

Accession MF_02108
Dates 5-OCT-2009 (Created)
29-JUN-2022 (Last updated, Version 14)
Name HTH_type_MurR
Bacteria; Enterobacterales
Template P77245 (MURR_ECOLI)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=HTH-type transcriptional regulator MurR;
AltName: Full=MurPQ operon repressor;
Gene name

Comments [?]

Function Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator.
Pathway Amino-sugar metabolism; N-acetylmuramate degradation [regulation].
Subunit Homotetramer.

Keywords [?]

Gene Ontology [?]

GO:0003700; Molecular function: DNA-binding transcription factor activity.
GO:0043470; Biological process: regulation of carbohydrate catabolic process.
GO:0045892; Biological process: negative regulation of DNA-templated transcription.

Cross-references [?]

PROSITE PS51071; HTH_RPIR; 1; trigger=PRU00390;
PS51464; SIS; 1; trigger=PRU00797;
Pfam PF01418; HTH_6; 1;
PF01380; SIS; 1;

Additional information [?]

Size range 266-287 amino acids
Related rules None
Fusion None