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Annotation rule MF_02114
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General rule information [?]

Accession MF_02114
Dates 6-AUG-2010 (Created)
23-MAY-2019 (Last updated, Version 7)
Name CofC
Scope
Bacteria; Actinobacteria
Bacteria; Chloroflexi
Bacteria; Proteobacteria
Bacteria; Thermobaculum
Archaea
Templates P9WP83 (FBID_MYCTU); Q58297 (COFC_METJA); A0QUZ4 (FBID_MYCS2); Q8PU52 (COFC_METMA): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

case <OC:Bacteria>
Identifier
FBID
Protein name
RecName: Full=Phosphoenolpyruvate guanylyltransferase;
Short=PEP guanylyltransferase;
EC=2.7.7.68;
Gene name
fbiD
else case <OC:Archaea>
Identifier
COFC
Protein name
RecName: Full=Phosphoenolpyruvate guanylyltransferase;
Short=PEP guanylyltransferase;
EC=2.7.7.68;
Gene name
cofC
end case

Comments [?]

Function Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
Catalytic activity Reaction=GTP + H(+) + phosphoenolpyruvate = diphosphate + enolpyruvoyl-2-diphospho-5'-guanosine; Xref=Rhea:RHEA:30519, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:58702, ChEBI:CHEBI:143701; EC=2.7.7.68;.
Pathway Cofactor biosynthesis; coenzyme F420 biosynthesis.
case <OC:Archaea>
Subunit Homodimer.
end case
Similarity Belongs to the CofC family.

Keywords [?]

GTP-binding
Nucleotide-binding
Nucleotidyltransferase
Transferase

Gene Ontology [?]

GO:0070568; Molecular function: guanylyltransferase activity.
GO:0009108; Biological process: coenzyme biosynthetic process.
GO:0052645; Biological process: F420-0 metabolic process.

Cross-references [?]

Pfam PF01983; CofC; 1;
TIGRFAMs TIGR03552; F420_cofC; 1;

Features [?]

From: FBID_MYCTU (P9WP83)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     148     148       Phosphoenolpyruvate; via amide nitrogen     T  
BINDING (Optional)     163     163       Phosphoenolpyruvate; via amide nitrogen     G  
BINDING     166     166       Phosphoenolpyruvate     S  

Additional information [?]

Size range 190-316 amino acids
Related rules None
Fusion None
Comments This enzyme was previously thought to use 2-phospho-L-lactate as substrate producing (2S)-lactyl-2-diphospho-5'-guanosine.


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