HAMAP rule MF_02114
General rule information
[?]
Accession |
MF_02114 |
Dates |
6-AUG-2010 (Created) 1-JUN-2023 (Last updated, Version 17) |
Scope |
Bacteria; Actinomycetota
Bacteria; Chloroflexota
Bacteria; Pseudomonadota
Bacteria; Thermobaculum
Archaea |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
case <OC:Archaea>
Protein name |
RecName:
|
Full=2-phospho-L-lactate guanylyltransferase;
|
|
Short=LP guanylyltransferase;
|
|
EC 2.7.7.68;
|
|
else case <OC:Actinomycetota>
Protein name |
RecName:
|
Full=Phosphoenolpyruvate guanylyltransferase;
|
|
Short=PEP guanylyltransferase;
|
|
EC 2.7.7.105;
|
|
else case <OC:Pseudomonadota>
Protein name |
RecName:
|
Full=3-phospho-D-glycerate guanylyltransferase;
|
|
Short=3PG guanylyltransferase;
|
|
EC 2.7.7.106;
|
|
else
Protein name |
RecName:
|
Full=Phosphoenolpyruvate guanylyltransferase;
|
|
Short=PEP guanylyltransferase;
|
|
EC 2.7.7.105;
|
|
end case
case <OC:Archaea>
Function |
Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor. |
else case <OC:Actinomycetota>
Function |
Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor. |
else case <OC:Pseudomonadota>
Function |
Guanylyltransferase that catalyzes the activation of (2R)-3-phosphoglycerate (3PG) as 3-[(R)-glyceryl]-diphospho-5'-guanosine, via the condensation of 3PG with GTP. It is involved in the biosynthesis of a derivative of the hydride carrier cofactor coenzyme F420, 3PG-F420. |
else
Function |
Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor. |
end case
case <OC:Archaea>
Catalytic activity |
RHEA:63424: (2S)-2-phospholactate + GTP + H(+) = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate
EC 2.7.7.68
|
else case <OC:Actinomycetota>
Catalytic activity |
RHEA:30519: GTP + H(+) + phosphoenolpyruvate = diphosphate + enolpyruvoyl-2-diphospho-5'-guanosine
EC 2.7.7.105
|
else case <OC:Pseudomonadota>
Catalytic activity |
RHEA:63440: (2R)-3-phosphoglycerate + GTP + H(+) = 3-[(R)-glyceryl]-diphospho-5'-guanosine + diphosphate
EC 2.7.7.106
|
else
Catalytic activity |
RHEA:30519: GTP + H(+) + phosphoenolpyruvate = diphosphate + enolpyruvoyl-2-diphospho-5'-guanosine
EC 2.7.7.105
|
end case
Pathway |
Cofactor biosynthesis; coenzyme F420 biosynthesis. |
case <OC:Archaea>
end case
Similarity |
Belongs to the CofC family. |
GO:0070568; Molecular function: guanylyltransferase activity.
GO:0052645; Biological process: F420-0 metabolic process.
case <OC:Actinomycetota>
From: FBID_MYCTU (P9WP83) |
Key
|
|
From
|
|
To
|
|
Description
|
|
Tag
|
|
Condition
|
|
FTGroup
|
BINDING
|
|
148
|
|
148
|
|
/ligand="phosphoenolpyruvate" /ligand_id="ChEBI:CHEBI:58702
|
|
|
|
T
|
|
|
BINDING (Optional)
|
|
163
|
|
163
|
|
/ligand="phosphoenolpyruvate" /ligand_id="ChEBI:CHEBI:58702
|
|
|
|
G
|
|
|
BINDING
|
|
166
|
|
166
|
|
/ligand="phosphoenolpyruvate" /ligand_id="ChEBI:CHEBI:58702
|
|
|
|
S
|
|
|
end case
Additional information
[?]
Size range |
190-316 amino acids |
Related rules |
None |
Fusion |
None |