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HAMAP rule MF_02114

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General rule information [?]

Accession MF_02114
Dates 6-AUG-2010 (Created)
1-JUN-2023 (Last updated, Version 17)
Name CofC
Scope
Bacteria; Actinomycetota
Bacteria; Chloroflexota
Bacteria; Pseudomonadota
Bacteria; Thermobaculum
Archaea
Templates P9WP83 (FBID_MYCTU); Q58297 (COFC_METJA); A0QUZ4 (FBID_MYCS2); Q8PU52 (COFC_METMA); E5ASS2 (FBID_MYCRK): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

case <OC:Archaea>
Identifier
COFC
Protein name
RecName: Full=2-phospho-L-lactate guanylyltransferase;
Short=LP guanylyltransferase;
EC 2.7.7.68;
Gene name
cofC
else case <OC:Actinomycetota>
Identifier
FBID
Protein name
RecName: Full=Phosphoenolpyruvate guanylyltransferase;
Short=PEP guanylyltransferase;
EC 2.7.7.105;
Gene name
fbiD
else case <OC:Pseudomonadota>
Identifier
FBID
Protein name
RecName: Full=3-phospho-D-glycerate guanylyltransferase;
Short=3PG guanylyltransferase;
EC 2.7.7.106;
Gene name
fbiD
else
Identifier
FBID
Protein name
RecName: Full=Phosphoenolpyruvate guanylyltransferase;
Short=PEP guanylyltransferase;
EC 2.7.7.105;
Gene name
fbiD
end case

Comments [?]

case <OC:Archaea>
Function Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
else case <OC:Actinomycetota>
Function Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
else case <OC:Pseudomonadota>
Function Guanylyltransferase that catalyzes the activation of (2R)-3-phosphoglycerate (3PG) as 3-[(R)-glyceryl]-diphospho-5'-guanosine, via the condensation of 3PG with GTP. It is involved in the biosynthesis of a derivative of the hydride carrier cofactor coenzyme F420, 3PG-F420.
else
Function Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
end case
case <OC:Archaea>
Catalytic activity RHEA:63424: (2S)-2-phospholactate + GTP + H(+) = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate
EC 2.7.7.68
else case <OC:Actinomycetota>
Catalytic activity RHEA:30519: GTP + H(+) + phosphoenolpyruvate = diphosphate + enolpyruvoyl-2-diphospho-5'-guanosine
EC 2.7.7.105
else case <OC:Pseudomonadota>
Catalytic activity RHEA:63440: (2R)-3-phosphoglycerate + GTP + H(+) = 3-[(R)-glyceryl]-diphospho-5'-guanosine + diphosphate
EC 2.7.7.106
else
Catalytic activity RHEA:30519: GTP + H(+) + phosphoenolpyruvate = diphosphate + enolpyruvoyl-2-diphospho-5'-guanosine
EC 2.7.7.105
end case
Pathway Cofactor biosynthesis; coenzyme F420 biosynthesis.
case <OC:Archaea>
Subunit Homodimer.
end case
Similarity Belongs to the CofC family.

Cross-references [?]

Pfam PF01983; CofC; 1;
NCBIfam TIGR03552; F420_cofC; 1;

Keywords [?]

GTP-binding
Nucleotide-binding
Nucleotidyltransferase
Transferase

Gene Ontology [?]

GO:0070568; Molecular function: guanylyltransferase activity.
GO:0052645; Biological process: F420-0 metabolic process.

Features [?]

case <OC:Actinomycetota>
From: FBID_MYCTU (P9WP83)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     148     148       /ligand="phosphoenolpyruvate" /ligand_id="ChEBI:CHEBI:58702     T  
BINDING (Optional)     163     163       /ligand="phosphoenolpyruvate" /ligand_id="ChEBI:CHEBI:58702     G  
BINDING     166     166       /ligand="phosphoenolpyruvate" /ligand_id="ChEBI:CHEBI:58702     S  
end case

Additional information [?]

Size range 190-316 amino acids
Related rules None
Fusion None


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