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HAMAP rule MF_02121

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General rule information [?]

Accession MF_02121
Dates 10-JUN-2011 (Created)
1-JUN-2023 (Last updated, Version 10)
Scope(s) Bacteria
Template(s) P0A9Q9 (DHAS_ECOLI); P9WNX5 (DHAS_MYCTU); P44801 (DHAS_HAEIN); P23247 (DHAS2_VIBCH); Q9KQG2 (DHAS1_VIBCH); Q51344 (DHAS_PSEAE); Q57658 (DHAS_METJA); P0A1F8 (DHAS_SALTY); [ Recover all ]
Triggered by HAMAP; MF_02121 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier DHAS
Protein name RecName: Full=Aspartate-semialdehyde dehydrogenase;
                 Short=ASA dehydrogenase;
AltName: Full=Aspartate-beta-semialdehyde dehydrogenase;
Gene name Name=asd;

Comments [?]

FUNCTIONCatalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate.
CATALYTIC ACTIVITY Reaction=L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho- L-aspartate + H(+) + NADPH; Xref=Rhea:RHEA:24284, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57535, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:537519; EC=;
PATHWAYAmino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.
PATHWAYAmino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.
PATHWAYAmino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.
SIMILARITYBelongs to the aspartate-semialdehyde dehydrogenase family.

Keywords [?]

Gene Ontology [?]

GO:0004073; Molecular function:aspartate-semialdehyde dehydrogenase activity
GO:0050661; Molecular function:NADP binding
GO:0071266; Biological process:'de novo' L-methionine biosynthetic process
GO:0009088; Biological process:threonine biosynthetic process
GO:0009089; Biological process:lysine biosynthetic process via diaminopimelate
GO:0019877; Biological process:diaminopimelate biosynthetic process

Cross-references [?]

PROSITE PS01103; ASD; 1;
Pfam PF01118; Semialdhyde_dh; 1;
Pfam PF02774; Semialdhyde_dhC; 1;
NCBIfam TIGR01745; Asd_gamma; 1;
NCBIfam TIGR01296; Asd_B; 1;
NCBIfam TIGR00978; Asd_EA; 1;
PIRSF PIRSF000148; ASA_dh; 1;

Features [?]

Key From To Description Tag Condition FTGroup
BINDING 10 13 /ligand="NADP(+)"
BINDING 37 38 /ligand="NADP(+)"
BINDING 165 166 /ligand="NADP(+)"
ACT_SITE 135 135 /note="Acyl-thioester intermediate" C
ACT_SITE 274 274 /note="Proton acceptor" H
BINDING 73 73 /ligand="NADP(+)"
BINDING 102 102 /ligand="phosphate"
BINDING 162 162 /ligand="substrate" Q
BINDING 193 193 /ligand="NADP(+)"
BINDING 267 267 /ligand="substrate" R
case not <OC:Archaea> and not <OC:Spirochaetota>
BINDING 241 241 /ligand="substrate" E
BINDING 244 244 /ligand="phosphate"
BINDING 350 350 /ligand="NADP(+)"
end case
From: DHAS_METJA (Q57658)
Key From To Description Tag Condition FTGroup
case <OC:Archaea> or <OC:Spirochaetota>
BINDING 210 210 /ligand="substrate" E
BINDING 213 213 /ligand="phosphate"
BINDING 333 334 /ligand="NADP(+)"
end case

Additional information [?]

Size range 337-376 amino acids
Related rules None
Fusion Nter: None Cter: None

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