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Annotation rule MF_02121
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General rule information [?]

Accession MF_02121
Dates 10-JUN-2011 (Created)
20-NOV-2019 (Last updated, Version 6)
Name ASADH
Scope
Bacteria
Archaea
Templates P0A9Q9 (DHAS_ECOLI); P9WNX5 (DHAS_MYCTU); P44801 (DHAS_HAEIN); P23247 (DHAS2_VIBCH); Q9KQG2 (DHAS1_VIBCH); Q51344 (DHAS_PSEAE); Q57658 (DHAS_METJA); P0A1F8 (DHAS_SALTY): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
DHAS
Protein name
RecName: Full=Aspartate-semialdehyde dehydrogenase;
Short=ASA dehydrogenase;
Short=ASADH;
EC 1.2.1.11;
AltName: Full=Aspartate-beta-semialdehyde dehydrogenase;
Gene name
asd

Comments [?]

Function Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
Catalytic activity RHEA:24284: L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH
EC 1.2.1.11
Pathway Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.
Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.
Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.
Subunit Homodimer.
Similarity Belongs to the aspartate-semialdehyde dehydrogenase family.

Keywords [?]

Amino-acid biosynthesis
Diaminopimelate biosynthesis
Lysine biosynthesis
Methionine biosynthesis
NADP
Oxidoreductase
Threonine biosynthesis

Gene Ontology [?]

GO:0004073; Molecular function: aspartate-semialdehyde dehydrogenase activity.
GO:0050661; Molecular function: NADP binding.
GO:0071266; Biological process: 'de novo' L-methionine biosynthetic process.
GO:0009088; Biological process: threonine biosynthetic process.
GO:0009089; Biological process: lysine biosynthetic process via diaminopimelate.
GO:0019877; Biological process: diaminopimelate biosynthetic process.

Cross-references [?]

PROSITE PS01103; ASD; 1;
Pfam PF01118; Semialdhyde_dh; 1;
PF02774; Semialdhyde_dhC; 1;
TIGRFAMs TIGR01745; Asd_gamma; 1;
TIGR01296; Asd_B; 1;
TIGR00978; Asd_EA; 1;
PIRSF PIRSF000148; ASA_dh; 1;

Features [?]

From: DHAS_ECOLI (P0A9Q9)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     10     13       NADP     [RTS]-G-x-[VG]  
NP_BIND     37     38       NADP     [TRNKS]-S  
NP_BIND     165     166       NADP     S-G  
ACT_SITE     135     135       Acyl-thioester intermediate     C  
ACT_SITE     274     274       Proton acceptor     H  
BINDING (Optional)     73     73       NADP     Q  
BINDING     102     102       Phosphate     R  
BINDING     162     162       Substrate     Q  
BINDING (Optional)     193     193       NADP; via carbonyl oxygen     P  
BINDING     267     267       Substrate     R  
case not <OC:Archaea> and not <OC:Spirochaetes>
BINDING (Optional)     241     241       Substrate     E  
BINDING     244     244       Phosphate     K  
BINDING     350     350       NADP     [QN]  
end case
case <OC:Archaea> or <OC:Spirochaetes>
From: DHAS_METJA (Q57658)
BINDING     210     210       Substrate     E  
BINDING     213     213       Phosphate     K  
NP_BIND     333     334       NADP     N-T  
end case

Additional information [?]

Size range 337-376 amino acids
Related rules None
Fusion None


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