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Annotation rule MF_02121 |
General rule information
[?]
Accession |
MF_02121 |
Dates |
10-JUN-2011 (Created) 20-NOV-2019 (Last updated, Version 6) |
Propagated annotation
[?]
Identifier, protein and gene names
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Protein name |
RecName:
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Full=Aspartate-semialdehyde dehydrogenase;
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Short=ASA dehydrogenase;
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Short=ASADH;
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EC 1.2.1.11;
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AltName:
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Full=Aspartate-beta-semialdehyde dehydrogenase;
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Function |
Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate. |
Catalytic activity |
RHEA:24284: L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH
EC 1.2.1.11
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Pathway |
Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4. |
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Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3. |
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Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5. |
Subunit |
Homodimer. |
Similarity |
Belongs to the aspartate-semialdehyde dehydrogenase family. |
GO:0004073; Molecular function: aspartate-semialdehyde dehydrogenase activity.
GO:0050661; Molecular function: NADP binding.
GO:0071266; Biological process: 'de novo' L-methionine biosynthetic process.
GO:0009088; Biological process: threonine biosynthetic process.
GO:0009089; Biological process: lysine biosynthetic process via diaminopimelate.
GO:0019877; Biological process: diaminopimelate biosynthetic process.
From: DHAS_ECOLI (P0A9Q9) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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NP_BIND
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10
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13
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NADP
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[RTS]-G-x-[VG]
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NP_BIND
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37
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38
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NADP
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[TRNKS]-S
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NP_BIND
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165
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166
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NADP
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S-G
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ACT_SITE
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135
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135
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Acyl-thioester intermediate
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C
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ACT_SITE
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274
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274
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Proton acceptor
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H
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BINDING (Optional)
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73
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73
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NADP
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Q
|
|
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BINDING
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102
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102
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Phosphate
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|
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R
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BINDING
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162
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162
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Substrate
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|
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Q
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|
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BINDING (Optional)
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193
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193
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NADP; via carbonyl oxygen
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P
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BINDING
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267
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267
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Substrate
|
|
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R
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case not <OC:Archaea> and not <OC:Spirochaetes>
BINDING (Optional)
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241
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241
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Substrate
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|
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E
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BINDING
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244
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244
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Phosphate
|
|
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K
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BINDING
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350
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350
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NADP
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[QN]
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end case
case <OC:Archaea> or <OC:Spirochaetes>
From: DHAS_METJA (Q57658) |
BINDING
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210
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210
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Substrate
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E
|
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BINDING
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213
|
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213
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Phosphate
|
|
|
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K
|
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NP_BIND
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333
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334
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NADP
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N-T
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end case
Additional information
[?]
Size range |
337-376 amino acids |
Related rules |
None |
Fusion |
None |