HAMAP rule MF_02122
General rule information
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Accession | MF_02122 |
Dates | 2-AUG-2011 (Created) 1-JUN-2023 (Last updated, Version 14) |
Name | DapD_type2 |
Scope | Bacteria; Actinomycetota
Bacteria; Pseudomonadota |
Template | P9WP21 (DAPD_MYCTU) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. |
Catalytic activity | RHEA:17325: (S)-2,3,4,5-tetrahydrodipicolinate + H2O + succinyl-CoA = (S)-2-succinylamino-6-oxoheptanedioate + CoA
EC 2.3.1.117 |
Pathway | Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 1/3. |
Subunit | Homotrimer. |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the type 2 tetrahydrodipicolinate N-succinyltransferase family. |
Keywords
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Acyltransferase
Amino-acid biosynthesis
Cytoplasm
Diaminopimelate biosynthesis
Lysine biosynthesis
Transferase
Amino-acid biosynthesis
Cytoplasm
Diaminopimelate biosynthesis
Lysine biosynthesis
Transferase
case <FT:4> or <FT:5>
end case
Gene Ontology
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case <FT:4> or <FT:5>
GO:0000287; Molecular function: magnesium ion binding.
end case
GO:0008666; Molecular function: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity.
GO:0009089; Biological process: lysine biosynthetic process via diaminopimelate.
GO:0019877; Biological process: diaminopimelate biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
GO:0009089; Biological process: lysine biosynthetic process via diaminopimelate.
GO:0019877; Biological process: diaminopimelate biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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Features
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From: DAPD_MYCTU (P9WP21) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 199 | 199 | Acyl-anhydride intermediate | E | ||||||||
BINDING | 257 | 258 | /ligand="succinyl-CoA" /ligand_id="ChEBI:CHEBI:57292 | [ED]-[AGS] | ||||||||
BINDING | 290 | 293 | /ligand="succinyl-CoA" /ligand_id="ChEBI:CHEBI:57292 | R-[RQ]-x-S | ||||||||
BINDING (Optional) | 166 | 166 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1" /ligand_note="ligand shared between trimeric partners | D | ||||||||
BINDING (Optional) | 183 | 183 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2" /ligand_note="ligand shared between trimeric partners | E | ||||||||
BINDING | 201 | 201 | /ligand="succinyl-CoA" /ligand_id="ChEBI:CHEBI:57292 | R | ||||||||
BINDING | 216 | 216 | /ligand="succinyl-CoA" /ligand_id="ChEBI:CHEBI:57292 | [GA] | ||||||||
BINDING | 219 | 219 | /ligand="succinyl-CoA" /ligand_id="ChEBI:CHEBI:57292 | S | ||||||||
BINDING | 242 | 242 | /ligand="succinyl-CoA" /ligand_id="ChEBI:CHEBI:57292 | A | ||||||||
BINDING | 265 | 265 | /ligand="succinyl-CoA" /ligand_id="ChEBI:CHEBI:57292 | G | ||||||||
BINDING | 277 | 277 | /ligand="succinyl-CoA" /ligand_id="ChEBI:CHEBI:57292 | K |
Additional information
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Size range | 297-401 amino acids |
Related rules | None |
Fusion | None |
Comments | There is another family of DapD (see MF_00811). |