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HAMAP rule MF_02122

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General rule information [?]

Accession MF_02122
Dates 2-AUG-2011 (Created)
1-JUN-2023 (Last updated, Version 14)
Name DapD_type2
Bacteria; Actinomycetota
Bacteria; Pseudomonadota
Template P9WP21 (DAPD_MYCTU)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase;
AltName: Full=Tetrahydrodipicolinate N-succinyltransferase;
Short=THDP succinyltransferase;
Short=THP succinyltransferase;
AltName: Full=Tetrahydropicolinate succinylase;
Gene name

Comments [?]

Function Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.
Catalytic activity RHEA:17325: (S)-2,3,4,5-tetrahydrodipicolinate + H2O + succinyl-CoA = (S)-2-succinylamino-6-oxoheptanedioate + CoA
Pathway Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 1/3.
Subunit Homotrimer.
Subcellular location Cytoplasm.
Similarity Belongs to the type 2 tetrahydrodipicolinate N-succinyltransferase family.

Keywords [?]

case <FT:4> or <FT:5>
end case

Gene Ontology [?]

case <FT:4> or <FT:5>
GO:0000287; Molecular function: magnesium ion binding.
end case
GO:0008666; Molecular function: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity.
GO:0009089; Biological process: lysine biosynthetic process via diaminopimelate.
GO:0019877; Biological process: diaminopimelate biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

NCBIfam TIGR03535; DapD_actino; 1;
TIGR03536; DapD_gpp; 1;

Features [?]

Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     199     199       Acyl-anhydride intermediate     E  
BINDING     257     258       /ligand="succinyl-CoA" /ligand_id="ChEBI:CHEBI:57292     [ED]-[AGS]  
BINDING     290     293       /ligand="succinyl-CoA" /ligand_id="ChEBI:CHEBI:57292     R-[RQ]-x-S  
BINDING (Optional)     166     166       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1" /ligand_note="ligand shared between trimeric partners     D  
BINDING (Optional)     183     183       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2" /ligand_note="ligand shared between trimeric partners     E  
BINDING     201     201       /ligand="succinyl-CoA" /ligand_id="ChEBI:CHEBI:57292     R  
BINDING     216     216       /ligand="succinyl-CoA" /ligand_id="ChEBI:CHEBI:57292     [GA]  
BINDING     219     219       /ligand="succinyl-CoA" /ligand_id="ChEBI:CHEBI:57292     S  
BINDING     242     242       /ligand="succinyl-CoA" /ligand_id="ChEBI:CHEBI:57292     A  
BINDING     265     265       /ligand="succinyl-CoA" /ligand_id="ChEBI:CHEBI:57292     G  
BINDING     277     277       /ligand="succinyl-CoA" /ligand_id="ChEBI:CHEBI:57292     K  

Additional information [?]

Size range 297-401 amino acids
Related rules None
Fusion None
Comments There is another family of DapD (see MF_00811).