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HAMAP rule MF_02122

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General rule information [?]

Accession MF_02122
Dates 2-AUG-2011 (Created)
2-SEP-2024 (Last updated, Version 15)
Name DapD_type2
Scope(s) Bacteria
Actinomycetota
Pseudomonadota
Template(s) P9WP21 (DAPD_MYCTU); [ Recover all ]
Triggered by HAMAP; MF_02122 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier DAPD
Protein name RecName: Full=2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase;
                 EC=2.3.1.117;
AltName: Full=Tetrahydrodipicolinate N-succinyltransferase;
                 Short=THDP succinyltransferase;
                 Short=THP succinyltransferase;
AltName: Full=Tetrahydropicolinate succinylase;
Gene name Name=dapD;

Comments [?]

FUNCTIONCatalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.
CATALYTIC ACTIVITY Reaction=(S)-2,3,4,5-tetrahydrodipicolinate + succinyl-CoA + H2O = (S)- 2-succinylamino-6-oxoheptanedioate + CoA; Xref=Rhea:RHEA:17325, ChEBI:CHEBI:15377, ChEBI:CHEBI:15685, ChEBI:CHEBI:16845, ChEBI:CHEBI:57287, ChEBI:CHEBI:57292; EC=2.3.1.117;
PATHWAYAmino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 1/3.
SUBUNITHomotrimer.
SUBCELLULAR LOCATIONCytoplasm.
SIMILARITYBelongs to the type 2 tetrahydrodipicolinate N- succinyltransferase family.

Keywords [?]


Gene Ontology [?]

case <FT:4> or <FT:5>
GO:0000287; Molecular function:magnesium ion binding
end case
GO:0008666; Molecular function:2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity
GO:0009089; Biological process:lysine biosynthetic process via diaminopimelate
GO:0019877; Biological process:diaminopimelate biosynthetic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

NCBIfam TIGR03535; DapD_actino; 1;
NCBIfam TIGR03536; DapD_gpp; 1;

Features [?]

From: DAPD_MYCTU (P9WP21)
Key From To Description Tag Condition FTGroup
ACT_SITE 199 199 /note="Acyl-anhydride intermediate" E
BINDING 257 258 /ligand="succinyl-CoA"
/ligand_id="ChEBI:CHEBI:57292"
[ED]-[AGS]
BINDING 290 293 /ligand="succinyl-CoA"
/ligand_id="ChEBI:CHEBI:57292"
R-[RQ]-x-S
BINDING 166 166 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
/ligand_label="1"
/ligand_note="ligand shared between trimeric partners"
D
BINDING 183 183 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
/ligand_label="2"
/ligand_note="ligand shared between trimeric partners"
E
BINDING 201 201 /ligand="succinyl-CoA"
/ligand_id="ChEBI:CHEBI:57292"
R
BINDING 216 216 /ligand="succinyl-CoA"
/ligand_id="ChEBI:CHEBI:57292"
[GA]
BINDING 219 219 /ligand="succinyl-CoA"
/ligand_id="ChEBI:CHEBI:57292"
S
BINDING 242 242 /ligand="succinyl-CoA"
/ligand_id="ChEBI:CHEBI:57292"
A
BINDING 265 265 /ligand="succinyl-CoA"
/ligand_id="ChEBI:CHEBI:57292"
G
BINDING 277 277 /ligand="succinyl-CoA"
/ligand_id="ChEBI:CHEBI:57292"
K

Additional information [?]

Size range 297-401 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments There is another family of DapD (see MF_00811).



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