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Annotation rule MF_02122
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General rule information [?]

Accession MF_02122
Dates 2-AUG-2011 (Created)
21-JAN-2020 (Last updated, Version 8)
Name DapD_type2
Scope
Bacteria; Actinobacteria
Bacteria; Proteobacteria
Template P9WP21 (DAPD_MYCTU)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
DAPD
Protein name
RecName: Full=2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase;
EC 2.3.1.117;
AltName: Full=Tetrahydrodipicolinate N-succinyltransferase;
Short=THDP succinyltransferase;
Short=THP succinyltransferase;
AltName: Full=Tetrahydropicolinate succinylase;
Gene name
dapD

Comments [?]

Function Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.
Catalytic activity RHEA:17325: (S)-2,3,4,5-tetrahydrodipicolinate + H2O + succinyl-CoA = (S)-2-succinylamino-6-oxoheptanedioate + CoA
EC 2.3.1.117
Pathway Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 1/3.
Subunit Homotrimer.
Subcellular location Cytoplasm.
Similarity Belongs to the type 2 tetrahydrodipicolinate N-succinyltransferase family.

Keywords [?]

Acyltransferase
Amino-acid biosynthesis
Cytoplasm
Diaminopimelate biosynthesis
Lysine biosynthesis
Transferase
case <FT:4> or <FT:5>
Magnesium
Metal-binding
end case

Gene Ontology [?]

case <FT:4> or <FT:5>
GO:0000287; Molecular function: magnesium ion binding.
end case
GO:0008666; Molecular function: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity.
GO:0009089; Biological process: lysine biosynthetic process via diaminopimelate.
GO:0019877; Biological process: diaminopimelate biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

TIGRFAMs TIGR03535; DapD_actino; 1;
TIGR03536; DapD_gpp; 1;

Features [?]

From: DAPD_MYCTU (P9WP21)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     199     199       Acyl-anhydride intermediate     E  
REGION     257     258       Succinyl-CoA binding     [ED]-[AGS]  
REGION     290     293       Succinyl-CoA binding     R-[RQ]-x-S  
METAL (Optional)     166     166       Magnesium 1; shared with trimeric partners     D  
METAL (Optional)     183     183       Magnesium 2; shared with trimeric partners     E  
BINDING     201     201       Succinyl-CoA     R  
BINDING     216     216       Succinyl-CoA; via amide nitrogen     [GA]  
BINDING     219     219       Succinyl-CoA     S  
BINDING     242     242       Succinyl-CoA; via amide nitrogen     A  
BINDING     265     265       Succinyl-CoA; via carbonyl oxygen     G  
BINDING     277     277       Succinyl-CoA     K  

Additional information [?]

Size range 297-401 amino acids
Related rules None
Fusion None
Comments There is another family of DapD (see MF_00811).


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